scholarly journals Canine Distemper in an Isolated Population of Fishers (Martes pennanti) from California

2012 ◽  
Vol 48 (4) ◽  
pp. 1035-1041 ◽  
Author(s):  
Stefan M. Keller ◽  
Mourad Gabriel ◽  
Karen A. Terio ◽  
Edward J. Dubovi ◽  
Elizabeth VanWormer ◽  
...  
Keyword(s):  
Isolated Population ◽  
Martes Pennanti ◽  
Canine Distemper

scholarly journals Infection of eight mesocarnivores in New Hampshire and Vermont with a distinct clade of canine distemper virus in 2016–2017

2019 ◽  
Vol 31 (4) ◽  
pp. 562-567 ◽  
Author(s):  
David B. Needle ◽  
Vivien C. Burnell ◽  
Marίa J. Forzán ◽  
Edward J. Dubovi ◽  
Krysten L. Schuler ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
New England ◽  
Biliary Tract ◽  
New Hampshire ◽  
Canine Distemper Virus ◽  
Virus Isolation ◽  
Mephitis Mephitis ◽  
Martes Pennanti ◽  
Canine Distemper ◽  
Urocyon Cinereoargenteus

Three fishers ( Martes pennanti), 2 gray foxes ( Urocyon cinereoargenteus), 1 mink ( Neovison vison), 1 skunk ( Mephitis mephitis), and 1 raccoon ( Procyon lotor), from Vermont and New Hampshire, had lesions on autopsy consistent with canine distemper virus (CDV) infections diagnosed in a 12-mo period in 2016–2017. Lesions of CDV infection were most commonly noted in the lungs (8 of 8 animals), urothelium (5 of 8), biliary tract (5 of 8), gastrointestinal tract (4 of 7), and brain (4 of 6). Splenic lesions were seen in 3 animals. The diagnosis was confirmed via immunohistochemistry and virus isolation. Viral genotyping indicated that all 8 animals were infected with a distinct clade of CDV that has only been reported in wildlife in New England, and this clade of viruses is distinct from vaccine strains. During the 12 mo when these cases occurred, no other CDV clade was identified in any other wildlife or domesticated animal submitted from the 2 states.

Low Titers of Canine Distemper Virus Antibody in Wild Fishers (Martes pennanti) in the Eastern USA

2016 ◽  
Vol 52 (1) ◽  
pp. 150-153
Author(s):  
Steven T. Peper ◽  
Randall L. Peper ◽  
Denise H. Mitcheltree ◽  
George V. Kollias ◽  
Robert P. Brooks ◽  
...  
Keyword(s):  
Canine Distemper Virus ◽  
Martes Pennanti ◽  
Canine Distemper ◽  
Virus Antibody ◽  
Eastern Usa

scholarly journals Utility of two modified-live virus canine distemper vaccines in wild-caught fishers (Martes pennanti)

2015 ◽  
Vol 36 (4) ◽  
pp. 197-202 ◽  
Author(s):  
Steven T. Peper ◽  
Randall L. Peper ◽  
Denise H. Mitcheltree ◽  
George V. Kollias ◽  
Robert P. Brooks ◽  
...  
Keyword(s):  
Martes Pennanti ◽  
Canine Distemper ◽  
Live Virus

High prevalence of diabetes in young Pima Indians: evidence of phenotypic variation in a genetically isolated population

Diabetes ◽  
1979 ◽  
Vol 28 (10) ◽  
pp. 937-942 ◽  
Author(s):  
P. J. Savage ◽  
P. H. Bennett ◽  
R. G. Senter ◽  
M. Miller
Keyword(s):  
Phenotypic Variation ◽  
Isolated Population ◽  
Pima Indians ◽  
High Prevalence

The First Record of Tesselated Snake, Natrix tesselata Laurenti, 1768 in the Central Chernozem Territory of Russia and Some Other Results of the Herpetological Research in the Upper Don

2011 ◽  
Vol 4 (2) ◽  
pp. 192-194
Author(s):  
Georgy A. Lada ◽  
V. Y. Nedosekin
Keyword(s):  
Rana Temporaria ◽  
First Record ◽  
Isolated Population ◽  
Common Frog ◽  
Northern Border ◽  
Frog Rana Temporaria ◽  
Bombina Bombina ◽  
Central Chernozem

A small isolated population of tesselated snake, Natrix tesselata was found in the Upper Don (Lipetsk Region, Russia). It is the first record of this species in the Central Chernozem Territory of Russia, which is separated from the northern border of the main range by the distance of about 200 km. An isolated population of common frog, Rana temporaria and phenetically peculiar population of fire-bellied toad, Bombina bombina are found here too. Faunistic aspect of new herpetological records is discussed.

Population fragmentation causes inadequate gene flow and increases extinction risk

2017 ◽  
Author(s):  
Richard Frankham ◽  
Jonathan D. Ballou ◽  
Katherine Ralls ◽  
Mark D. B. Eldridge ◽  
Michele R. Dudash ◽  
...  
Keyword(s):  
Gene Flow ◽  
Extinction Risk ◽  
Random Mating ◽  
Large Population ◽  
Isolated Population ◽  
Population Fragmentation ◽  
Single Population ◽  
Total Size ◽  
Limited Gene Flow

Most species now have fragmented distributions, often with adverse genetic consequences. The genetic impacts of population fragmentation depend critically upon gene flow among fragments and their effective sizes. Fragmentation with cessation of gene flow is highly harmful in the long term, leading to greater inbreeding, increased loss of genetic diversity, decreased likelihood of evolutionary adaptation and elevated extinction risk, when compared to a single population of the same total size. The consequences of fragmentation with limited gene flow typically lie between those for a large population with random mating and isolated population fragments with no gene flow.

Evolution, natural history, and conservation of black-footed ferrets

2018 ◽  
Author(s):  
Dean E. Biggins ◽  
David A. Eads
Keyword(s):  
Natural History ◽  
Captive Breeding ◽  
Alpine Meadow ◽  
Selective Pressure ◽  
Canine Distemper ◽  
Prairie Dog ◽  
Management Tools ◽  
Diverse Area ◽  
Close Relatives ◽  
Remnant Population

Black-footed ferrets were reduced to a remnant population of 10 in 1985 due to diseases (plague, canine distemper), but successful captive breeding and releases have improved the prospects for ferret recovery. Comparisons between black-footed ferrets and Siberian polecats, close relatives that can interbreed and produce fertile offspring, allow the following evolutionary speculation. Predation on ferrets and polecats tends to narrow their niches and promote specialization due to requirements for escape habitats. In Asia, that influence is countered by the larger and more diverse area of steppe and alpine meadow habitats for polecats, and by plague which causes large variation in prey abundance. In North America, the selective pressure favoring specialization in ferrets on prairie dog prey and burrows had no strong counter-force before plague invaded. Plague is an immense challenge to black-footed ferret recovery, and several management tools including vaccines and vector control may be necessary to conserve the species.

scholarly journals Intratumoral Canine Distemper Virus Infection Inhibits Tumor Growth by Modulation of the Tumor Microenvironment in a Murine Xenograft Model of Canine Histiocytic Sarcoma

2021 ◽  
Vol 22 (7) ◽  
pp. 3578
Author(s):  
Federico Armando ◽  
Adnan Fayyad ◽  
Stefanie Arms ◽  
Yvonne Barthel ◽  
Dirk Schaudien ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Virus Infection ◽  
Tumor Growth ◽  
Canine Distemper Virus ◽  
Xenograft Model ◽  
Histiocytic Sarcoma ◽  
Oncolytic Viruses ◽  
Canine Distemper ◽  
Murine Xenograft Model ◽  
The Impact

Histiocytic sarcomas refer to highly aggressive tumors with a poor prognosis that respond poorly to conventional treatment approaches. Oncolytic viruses, which have gained significant traction as a cancer therapy in recent decades, represent a promising option for treating histiocytic sarcomas through their replication and/or by modulating the tumor microenvironment. The live attenuated canine distemper virus (CDV) vaccine strain Onderstepoort represents an attractive candidate for oncolytic viral therapy. In the present study, oncolytic virotherapy with CDV was used to investigate the impact of this virus infection on tumor cell growth through direct oncolytic effects or by virus-mediated modulation of the tumor microenvironment with special emphasis on angiogenesis, expression of selected MMPs and TIMP-1 and tumor-associated macrophages in a murine xenograft model of canine histiocytic sarcoma. Treatment of mice with xenotransplanted canine histiocytic sarcomas using CDV induced overt retardation in tumor progression accompanied by necrosis of neoplastic cells, increased numbers of intratumoral macrophages, reduced angiogenesis and modulation of the expression of MMPs and TIMP-1. The present data suggest that CDV inhibits tumor growth in a multifactorial way, including direct cell lysis and reduction of angiogenesis and modulation of MMPs and their inhibitor TIMP-1, providing further support for the concept of its role in oncolytic therapies.

scholarly journals Drivers of canine distemper virus exposure in dogs at a wildlife interface in Janos, Mexico

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Rocío Almuna ◽  
Andrés M. López‐Pérez ◽  
Rosa E. Sarmiento ◽  
Gerardo Suzán
Keyword(s):  
Canine Distemper Virus ◽  
Canine Distemper ◽  
Virus Exposure
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