Biodegradable and magnetic core–shell composite particle prepared by emulsion solvent diffusion method

2015 ◽  
Vol 55 (2S) ◽  
pp. 02BE01 ◽  
Author(s):  
Chiemi Oka ◽  
Kazunori Ushimaru ◽  
Nanao Horiishi ◽  
Takeharu Tsuge ◽  
Yoshitaka Kitamoto
Keyword(s):  
Composite Particle ◽  
Magnetic Core ◽  
Diffusion Method ◽  
Core Shell ◽  
Solvent Diffusion ◽  
Shell Composite ◽  
Emulsion Solvent Diffusion Method

scholarly journals PREPARATION, CHARACTERIZATION AND EVALUATION OF POLY (LACTIDE –CO –GLYCOLIDE) MICROSPHERES FOR THE CONTROLLED RELEASE OF ZIDOVUDINE

2017 ◽  
Vol 9 (12) ◽  
pp. 70 ◽  
Author(s):  
Seema Kohli ◽  
Abhisek Pal ◽  
Suchit Jain
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Average Particle ◽  
Plga Microspheres ◽  
Good Reproducibility ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

Objective: The purpose of this research work was to develop and evaluate microspheres appropriate for controlled release of zidovudine (AZT).Methods: The AZT loaded polylactide-co-glycolide (PLGA) microspheres were prepared by W/O/O double emulsion solvent diffusion method. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). The influence of formulation factors (drug: polymer ratio, stirring speed, the concentration of surfactant) on particle size encapsulation efficiency and in vitro release characteristics of the microspheres was investigated. Release kinetics was studied and stability study was performed as per ICH guidelines.Results: Scanning electron microscopy (SEM) images show good reproducibility of microspheres from different batches. The average particle size was in the range of 216-306 μm. The drug-loaded microspheres showed 74.42±5.08% entrapment efficiency. The cumulative percentage released in phosphate Buffer solution (PBS) buffer was found to be 55.32±5.89 to 74.42±5.08 %. The highest regressions (0.981) were obtained for zero order kinetics followed by Higuchi (0.968) and first order (0.803).Conclusion: Microsphere prepared by double emulsion solvent diffusion method was investigated and the results revealed that 216-306 μm microsphere was successfully encapsulated in a polymer. FT-IR analysis, entrapment efficiency and SEM Studies revealed the good reproducibility from batch to batch. The microspheres were of an appropriate size and suitable for oral administration. Thus the current investigation show promising results of PLGA microspheres as a matrix for drug delivery and merit for In vivo studies for scale up the technology.

Synthesis and properties of a magnetic core–shell composite nano-adsorbent for fluoride removal from drinking water

2014 ◽  
Vol 317 ◽  
pp. 552-559 ◽  
Author(s):  
Chang Zhang ◽  
Lin Chen ◽  
Ting-Jie Wang ◽  
Chao-Li Su ◽  
Yong Jin
Keyword(s):  
Drinking Water ◽  
Magnetic Core ◽  
Fluoride Removal ◽  
Core Shell ◽  
Shell Composite ◽  
Nano Adsorbent

Genipin-cross-linked silk fibroin microspheres prepared by the simple water-in-oil emulsion solvent diffusion method

2010 ◽  
Vol 203 (3) ◽  
pp. 603-608 ◽  
Author(s):  
Thanonchat Imsombut ◽  
Yaowalak Srisuwan ◽  
Prasong Srihanam ◽  
Yodthong Baimark
Keyword(s):  
Silk Fibroin ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method
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