scholarly journals Regulatory role of sorting nexin 5 in protein stability and vesicular targeting of vesicular acetylcholine transporter to synaptic vesicle-like vesicles in PC12 cells

2020 ◽  
Vol 1 (0) ◽  
pp. 1
Author(s):  
Meihen Sun ◽  
Xu Han ◽  
Fei Chang ◽  
Hongfei Xu ◽  
Lesley Colgan ◽  
...  
Keyword(s):  
Protein Stability ◽  
Synaptic Vesicle ◽  
Pc12 Cells ◽  
Regulatory Role ◽  
Vesicular Acetylcholine Transporter ◽  
Sorting Nexin ◽  
Sorting Nexin 5

scholarly journals Novel role of sorting nexin 5 in renal D 1 dopamine receptor trafficking and function: implications for hypertension

2012 ◽  
Vol 27 (5) ◽  
pp. 1808-1819 ◽  
Author(s):  
Van Anthony M. Villar ◽  
Ines Armando ◽  
Hironobu Sanada ◽  
Lauren C. Frazer ◽  
Christen M. Russo ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Trafficking ◽  
Sorting Nexin ◽  
And Function ◽  
Sorting Nexin 5

scholarly journals Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8

2018 ◽  
Vol 20 (5) ◽  
pp. 3403-3410 ◽  
Author(s):  
Kumiko Hayashi ◽  
Shin Hasegawa ◽  
Takashi Sagawa ◽  
Sohei Tasaki ◽  
Shinsuke Niwa
Keyword(s):  
Synaptic Vesicle ◽  
Axonal Transport ◽  
Force Measurement ◽  
Regulatory Role ◽  
Non Invasive

The regulatory role of ARL-8 in the number of motors carrying a cargo is revealed by non-invasive force measurement.

scholarly journals Caenorhabditis elegans Intersectin: A Synaptic Protein Regulating Neurotransmission

2007 ◽  
Vol 18 (12) ◽  
pp. 5091-5099 ◽  
Author(s):  
Simon Rose ◽  
Maria Grazia Malabarba ◽  
Claudia Krag ◽  
Anna Schultz ◽  
Hanako Tsushima ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptic Vesicle ◽  
Regulatory Role ◽  
Actin Dynamics ◽  
Synaptic Vesicle Recycling ◽  
Multifunctional Protein ◽  
C Elegans ◽  
Vesicle Recycling ◽  
Negative Regulatory Role

Intersectin is a multifunctional protein that interacts with components of the endocytic and exocytic pathways, and it is also involved in the control of actin dynamics. Drosophila intersectin is required for viability, synaptic development, and synaptic vesicle recycling. Here, we report the characterization of intersectin function in Caenorhabditis elegans. Nematode intersectin (ITSN-1) is expressed in the nervous system, and it is enriched in presynaptic regions. The C. elegans intersectin gene (itsn-1) is nonessential for viability. In addition, itsn-1-null worms do not display any evident phenotype, under physiological conditions. However, they display aldicarb-hypersensitivity, compatible with a negative regulatory role of ITSN-1 on neurotransmission. ITSN-1 physically interacts with dynamin and EHS-1, two proteins involved in synaptic vesicle recycling. We have previously shown that EHS-1 is a positive modulator of synaptic vesicle recycling in the nematode, likely through modulation of dynamin or dynamin-controlled pathways. Here, we show that ITSN-1 and EHS-1 have opposite effects on aldicarb sensitivity, and on dynamin-dependent phenotypes. Thus, the sum of our results identifies dynamin, or a dynamin-controlled pathway, as a potential target for the negative regulatory role of ITSN-1.

Regulatory role of resistin on ovarian function

2014 ◽  
Author(s):  
Agnieszka Rak-Mardyla ◽  
Anna Wrobel ◽  
Eliza Drwal ◽  
Ewa Gregoraszczuk
Keyword(s):  
Ovarian Function ◽  
Regulatory Role
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