scholarly journals Correction: Rapid DNA replication origin licensing protects stem cell pluripotency

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Jacob Peter Matson ◽  
Raluca Dumitru ◽  
Philip Coryell ◽  
Ryan M Baxley ◽  
Weili Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dna Replication ◽  
Replication Origin ◽  
Origin Licensing ◽  
Dna Replication Origin ◽  
Stem Cell Pluripotency

scholarly journals Author response: Rapid DNA replication origin licensing protects stem cell pluripotency

2017 ◽  
Author(s):  
Jacob Peter Matson ◽  
Raluca Dumitru ◽  
Philip Coryell ◽  
Ryan M Baxley ◽  
Weili Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dna Replication ◽  
Replication Origin ◽  
Author Response ◽  
Origin Licensing ◽  
Dna Replication Origin ◽  
Stem Cell Pluripotency

scholarly journals Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

Cell ◽  
2009 ◽  
Vol 139 (4) ◽  
pp. 719-730 ◽  
Author(s):  
Dirk Remus ◽  
Fabienne Beuron ◽  
Gökhan Tolun ◽  
Jack D. Griffith ◽  
Edward P. Morris ◽  
...  
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Origin Licensing ◽  
Dna Replication Origin

scholarly journals Investigating the regulation of DNA replication origin licensing during cellular quiescence

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Kate Elizabeth Coleman ◽  
Feng Yan ◽  
Ben Major ◽  
Jeanette Gowen Cook
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Origin Licensing ◽  
Dna Replication Origin ◽  
Cellular Quiescence

scholarly journals Rapid DNA Replication Origin Licensing Protects Stem Cell Pluripotency

2017 ◽  
Author(s):  
Jacob Peter Matson ◽  
Raluca Dumitru ◽  
Phillip Coryell ◽  
Ryan M Baxley ◽  
Weili Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Replication ◽  
Cell Types ◽  
Origin Licensing ◽  
Mcm Helicase ◽  
Dna Replication Origin ◽  
Stem Cell Pluripotency ◽  
Dna Replication Origins ◽  
Pluripotency Maintenance ◽  
Intrinsic Characteristic

ABSTRACTComplete and robust human genome duplication requires loading MCM helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, but G1 length varies widely among cell types. Using quantitative single cell analyses we found that pluripotent stem cells with naturally short G1 phases load MCM much faster than their isogenic differentiated counterparts with long G1 phases. During the earliest stages of differentiation towards all lineages, MCM loading slows concurrently with G1 lengthening, revealing developmental control of MCM loading. In contrast, ectopic Cyclin E overproduction uncouples short G1 from fast MCM loading. Rapid licensing in stem cells is caused by accumulation of the MCM loading protein, Cdt1. Prematurely slowing MCM loading in pluripotent cells not only lengthens G1 but also accelerates differentiation. Thus, rapid origin licensing is an intrinsic characteristic of stem cells that contributes to pluripotency maintenance.

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