scholarly journals Decision letter: Long-term consequences of the absence of leptin signaling in early life

2018 ◽  
Author(s):  
Richard D Palmiter
Keyword(s):  
Early Life ◽  
Leptin Signaling ◽  
Long Term Consequences

scholarly journals Author response: Long-term consequences of the absence of leptin signaling in early life

2018 ◽  
Author(s):  
Angela M Ramos-Lobo ◽  
Pryscila DS Teixeira ◽  
Isadora C Furigo ◽  
Helen M Melo ◽  
Natalia de M Lyra e Silva ◽  
...  
Keyword(s):  
Early Life ◽  
Author Response ◽  
Leptin Signaling ◽  
Long Term Consequences

scholarly journals Long-term consequences of the absence of leptin signaling in early life

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Angela M Ramos-Lobo ◽  
Pryscila DS Teixeira ◽  
Isadora C Furigo ◽  
Helen M Melo ◽  
Natalia de M Lyra e Silva ◽  
...  
Keyword(s):  
Early Life ◽  
Arcuate Nucleus ◽  
Leptin Receptor ◽  
Brain Growth ◽  
Leptin Signaling ◽  
Developmental Problems ◽  
The Poor ◽  
Long Term Consequences

Leptin regulates energy balance and also exhibits neurotrophic effects during critical developmental periods. However, the actual role of leptin during development is not yet fully understood. To uncover the importance of leptin in early life, the present study restored leptin signaling either at the fourth or tenth week of age in mice formerly null for the leptin receptor (LepR) gene. We found that some defects previously considered irreversible due to neonatal deficiency of leptin signaling, including the poor development of arcuate nucleus neural projections, were recovered by LepR reactivation in adulthood. However, LepR deficiency in early life led to irreversible obesity via suppression of energy expenditure. LepR reactivation in adulthood also led to persistent reduction in hypothalamic Pomc, Cartpt and Prlh mRNA expression and to defects in the reproductive system and brain growth. Our findings revealed that early defects in leptin signaling cause permanent metabolic, neuroendocrine and developmental problems.

scholarly journals Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience

2015 ◽  
Vol 53 ◽  
pp. 69-81 ◽  
Author(s):  
Benjamin D. Sachs ◽  
Ramona M. Rodriguiz ◽  
Ha L. Tran ◽  
Akshita Iyer ◽  
William C. Wetsel ◽  
...  
Keyword(s):  
Early Life ◽  
Life Experience ◽  
Early Life Experience ◽  
Serotonin Deficiency ◽  
Long Term Consequences

A long-term study of the effects of housing conditions on the welfare of domestic pigs

1993 ◽  
Vol 1993 ◽  
pp. 86-86
Author(s):  
M. Mendl ◽  
D.M. Broom ◽  
A.J. Zanella
Keyword(s):  
Early Life ◽  
Group Housing ◽  
Housing Conditions ◽  
Term Study ◽  
Housing Systems ◽  
Long Term Study ◽  
Alternative Systems ◽  
Long Term Consequences ◽  
Over Time

In view of the forthcoming UK ban on stall and tether housing for sows, the long-term consequences of housing pregnant pigs in alternative systems were assessed. The objective of the study was to examine the effects of two indoor group-housing systems on measures of the welfare of pregnant pigs, and to compare pigs housed in these systems with pigs housed in stalls. The study followed 63 female pigs from early life until their fourth pregnancy. A longitudinal experimental design was used to obtain information on how the pigs responded to their initial introduction to the three housing systems (during the first pregnancy), and how they adjusted to the systems over time (in the fourth pregnancy).

scholarly journals Why Social Exclusion Persists among Older People in Australia

2015 ◽  
Vol 3 (4) ◽  
pp. 112-126 ◽  
Author(s):  
Riyana Miranti ◽  
Peng Yu
Keyword(s):  
Older People ◽  
Social Exclusion ◽  
Household Income ◽  
Early Life ◽  
Health Conditions ◽  
Life Stages ◽  
Older Person ◽  
Early Life Stages ◽  
Long Term Consequences

The existing literature on social exclusion among older people, though relatively limited, suggests that disadvantage among older people is cumulative in nature. Some aspects of disadvantage starting at early life stages have long-term consequences. As such, older people with disadvantages may be subject to higher risks of persistent social exclusion. This article aims to improve understanding of social exclusion and its persistence among senior Australians in three ways. Firstly, the incidence of social exclusion among older people is analysed using selected indicators. Secondly, the study examines whether an older person experiencing social exclusion at one time is more likely to experience it again (persistence). Thirdly, it investigates what factors may be protecting older people from social exclusion. The analysis is conducted using the first eight waves of the Household, Income and Labour Dynamics in Australia (HILDA) Survey. The sample of older people is disaggregated into a younger group (55–64 years at wave 1) and an older group (65+ years). The article suggests that higher education and income, as well as better health conditions and previous employment experiences, are important protective factors from social exclusion for older Australians.

scholarly journals Long-term consequences of stunting in early life

2011 ◽  
Vol 7 ◽  
pp. 5-18 ◽  
Author(s):  
Kathryn G. Dewey ◽  
Khadija Begum
Keyword(s):  
Early Life ◽  
Long Term Consequences
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