scholarly journals Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Eva Plesch ◽  
Cheng-Chang Chen ◽  
Elisabeth Butz ◽  
Anna Scotto Rosato ◽  
Einar K Krogsaeter ◽  
...  
Keyword(s):  
Immune Cells ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Macrophage Migration ◽  
Direct Link ◽  
Direct Role ◽  
Recycling Endosomes ◽  
Cytokines And Chemokines ◽  
Selective Agonist ◽  
Stimulation Of

Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells. Here, the endolysosomal cation channel TRPML2 is shown to play a direct role in chemokine trafficking and secretion from murine macrophages. To demonstrate acute and direct involvement of TRPML2 in these processes, the first isoform-selective TRPML2 channel agonist was generated, ML2-SA1. ML2-SA1 was not only found to directly stimulate release of the chemokine CCL2 from macrophages but also to stimulate macrophage migration, thus mimicking CCL2 function. Endogenous TRPML2 is expressed in early/recycling endosomes as demonstrated by endolysosomal patch-clamp experimentation and ML2-SA1 promotes trafficking through early/recycling endosomes, suggesting CCL2 being transported and secreted via this pathway. These data provide a direct link between TRPML2 activation, CCL2 release and stimulation of macrophage migration in the innate immune response.

scholarly journals Author response: Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

2018 ◽  
Author(s):  
Eva Plesch ◽  
Cheng-Chang Chen ◽  
Elisabeth Butz ◽  
Anna Scotto Rosato ◽  
Einar K Krogsaeter ◽  
...  
Keyword(s):  
Immune Cells ◽  
Innate Immune ◽  
Author Response ◽  
Innate Immune Cells ◽  
Direct Role ◽  
Selective Agonist

scholarly journals Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists

2014 ◽  
Vol 136 (31) ◽  
pp. 10823-10825 ◽  
Author(s):  
Keun Ah Ryu ◽  
Lalisa Stutts ◽  
Janine K. Tom ◽  
Rock J. Mancini ◽  
Aaron P. Esser-Kahn
Keyword(s):  
Immune Cells ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Stimulation Of

scholarly journals Pannexin-1 Channels as Mediators of Neuroinflammation

2021 ◽  
Vol 22 (10) ◽  
pp. 5189
Author(s):  
Joon Ho Seo ◽  
Miloni S. Dalal ◽  
Jorge E. Contreras
Keyword(s):  
Immune Cells ◽  
Neurological Diseases ◽  
Atp Release ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Damage Site ◽  
Pannexin 1 ◽  
Cytokines And Chemokines ◽  
Secondary Damage ◽  
Dying Cells

Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of nearby tissues and might mediate the recruitment of leukocytes to the injury site. If this process persists or is exacerbated, it prevents the adequate resolution of the inflammation, and ultimately enhances secondary damage. Adenosine 5′ triphosphate (ATP) is among the molecules released that trigger an inflammatory response, and it serves as a chemotactic and endogenous danger signal. Extracellular ATP activates multiple purinergic receptors (P2X and P2Y) that have been shown to promote neuroinflammation in a variety of CNS diseases. Recent studies have shown that Pannexin-1 (Panx1) channels are the principal conduits of ATP release from dying cells and innate immune cells in the brain. Herein, we review the emerging evidence that directly implicates Panx-1 channels in the neuroinflammatory response in the CNS.

scholarly journals Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae

2002 ◽  
Vol 32 (9) ◽  
pp. 2460-2470 ◽  
Author(s):  
Clarissa Prazeres da Costa ◽  
Carsten J. Kirschning ◽  
Dirk Busch ◽  
Susanne Dürr ◽  
Luise Jennen ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Immune Cells ◽  
Chlamydia Pneumoniae ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Heat Shock Protein 60 ◽  
Stimulation Of

scholarly journals The MushroomAgaricus blazeiMurill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Geir Hetland ◽  
Egil Johnson ◽  
Torstein Lyberg ◽  
Gunnar Kvalheim
Keyword(s):  
Immune Cells ◽  
Rain Forest ◽  
Scientific Evidence ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Medicinal Mushroom ◽  
Agaricus Blazei ◽  
Health Food ◽  
Inflammatory Bowel ◽  
Stimulation Of

The medicinal mushroomAgaricus blazeiMurill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations.Agaricus blazeiM is rich in the immunomodulating polysaccharides,β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.

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