scholarly journals High temperature sensitivity is intrinsic to voltage-gated potassium channels

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Fan Yang ◽  
Jie Zheng
Keyword(s):  
High Temperature ◽  
Temperature Sensitivity ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Temperature Sensing ◽  
Temperature Sensitive ◽  
Heat Sensitivity ◽  
Voltage Gated ◽  
Kv Channels ◽  
High Temperature Sensitivity

Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous voltage-gated potassium (Kv) channels also exhibit high temperature sensitivity comparable to that of TRPV1, which is detectable under specific conditions when the voltage sensor is functionally decoupled from the activation gate through either intrinsic mechanisms or mutations. Interestingly, mutations could tune Shaker channel to be either heat-activated or heat-deactivated. Therefore, high temperature sensitivity is intrinsic to both TRP and Kv channels. Our findings suggest important physiological roles of heat-induced variation in Kv channel activities. Mechanistically our findings indicate that temperature-sensing TRP channels may not contain a specialized heat-sensor domain; instead, non-obligatory allosteric gating permits the intrinsic heat sensitivity to drive channel activation, allowing temperature-sensitive TRP channels to function as polymodal nociceptors.

scholarly journals Single-residue molecular switch for high-temperature dependence of vanilloid receptor TRPV3

2017 ◽  
Vol 114 (7) ◽  
pp. 1589-1594 ◽  
Author(s):  
Beiying Liu ◽  
Feng Qin
Keyword(s):  
High Temperature ◽  
Temperature Dependence ◽  
Temperature Sensitivity ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Vanilloid Receptor ◽  
Temperature Threshold ◽  
Heat Sensitivity ◽  
Transient Receptor

Thermal transient receptor potential (TRP) channels, a group of ion channels from the transient receptor potential family, play important functions in pain and thermal sensation. These channels are directly activated by temperature and possess strong temperature dependence. Furthermore, their temperature sensitivity can be highly dynamic and use-dependent. For example, the vanilloid receptor transient receptor potential 3 (TRPV3), which has been implicated as a warmth detector, becomes responsive to warm temperatures only after intensive stimulation. Upon initial activation, the channel exhibits a high-temperature threshold in the noxious temperature range above 50 °C. This use dependence of heat sensitivity thus provides a mechanism for sensitization of thermal channels. However, how the channels acquire the use dependence remains unknown. Here, by comparative studies of chimeric channels between use-dependent and use-independent homologs, we have determined the molecular basis that underlies the use dependence of temperature sensitivity of TRPV3. Remarkably, the restoration of a single residue that is apparently missing in the use-dependent homologs could largely eliminate the use dependence of heat sensitivity of TRPV3. The location of the region suggests a mechanism of temperature-dependent gating of thermal TRP channels involving an intracellular region assembled around the TRP domain.

scholarly journals Concentration-dependent spectroscopic properties and temperature sensing of YNbO4:Er3+ phosphors

RSC Advances ◽  
2017 ◽  
Vol 7 (38) ◽  
pp. 23751-23758 ◽  
Author(s):  
Xin Wang ◽  
Xiangping Li ◽  
Lihong Cheng ◽  
Sai Xu ◽  
Jiashi Sun ◽  
...  
Keyword(s):  
High Temperature ◽  
Temperature Sensitivity ◽  
Spectroscopic Properties ◽  
Temperature Sensing ◽  
Low Concentration ◽  
High Temperature Sensitivity

Er3+ concentration had significant influences on temperature sensitivity. The sample with a low concentration of Er3+ had high temperature sensitivity.

High performance optical temperature sensing via selectively partitioning Cr4+ in the residual SiO2-rich phase of glass-ceramics

2019 ◽  
Vol 21 (31) ◽  
pp. 17047-17053 ◽  
Author(s):  
Zhanwen Zhang ◽  
Xinfang Li ◽  
Changjian Wang ◽  
Xvsheng Qiao
Keyword(s):  
High Temperature ◽  
Silicate Glass ◽  
Temperature Sensitivity ◽  
High Performance ◽  
Glass Phase ◽  
Glass Ceramics ◽  
Temperature Sensing ◽  
Temperature Resolution ◽  
Rich Phase ◽  
High Temperature Sensitivity

Tetravalent Cr4+ is stabilized in the residual silicate glass phase to get high temperature sensitivity and high temperature resolution.

High-Temperature Sensitivity of a Depletion-Mode AlGaN/GaN MIS-HEMT

2021 ◽  
pp. 1-6
Author(s):  
Z. Mutsafi ◽  
K. Shimanovich ◽  
V. Kairys ◽  
R. Shima-Edelstein ◽  
Y. Roizin ◽  
...  
Keyword(s):  
High Temperature ◽  
Temperature Sensitivity ◽  
High Temperature Sensitivity

Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

2007 ◽  
Vol 292 (1) ◽  
pp. R37-R46 ◽  
Author(s):  
Andrej A. Romanovsky
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Open Loop ◽  
Temperature Sensitive ◽  
Functional Architecture ◽  
Set Point ◽  
Sequential Activation ◽  
Thermoregulatory System ◽  
Transient Receptor

While summarizing the current understanding of how body temperature (Tb) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention is paid to the functional architecture of the thermoregulatory system. The notion that deep Tb is regulated by a unified system with a single controller is rejected. It is proposed that Tb is regulated by independent thermoeffector loops, each having its own afferent and efferent branches. The activity of each thermoeffector is triggered by a unique combination of shell and core Tbs. Temperature-dependent phase transitions in thermosensory neurons cause sequential activation of all neurons of the corresponding thermoeffector loop and eventually a thermoeffector response. No computation of an integrated Tb or its comparison with an obvious or hidden set point of a unified system is necessary. Coordination between thermoeffectors is achieved through their common controlled variable, Tb. The described model incorporates Kobayashi’s views, but Kobayashi’s proposal to eliminate the term sensor is rejected. A case against the term set point is also made. Because this term is historically associated with a unified control system, it is more misleading than informative. The term balance point is proposed to designate the regulated level of Tb and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance.

High temperature-sensitivity sensor based on long period fiber grating inscribed with femtosecond laser transversal-scanning method

2017 ◽  
Vol 15 (9) ◽  
pp. 090602 ◽  
Author(s):  
Xinran Dong Xinran Dong ◽  
Zheng Xie Zheng Xie ◽  
Yuxin Song Yuxin Song ◽  
Kai Yin Kai Yin ◽  
Dongkai Chu Dongkai Chu ◽  
...  
Keyword(s):  
High Temperature ◽  
Femtosecond Laser ◽  
Temperature Sensitivity ◽  
Fiber Grating ◽  
Scanning Method ◽  
Long Period Fiber Grating ◽  
Long Period ◽  
Period Fiber Grating ◽  
High Temperature Sensitivity
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