Atypical Tenosynovial Giant Cell Tumor of the Foot and Ankle: A Case Report

2021 ◽  
Vol 111 (3) ◽  
Author(s):  
Peter Awad
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissue Tumor ◽  
Imaging Modality ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Tenosynovial Giant Cell Tumor ◽  
Tissue Tumor ◽  
Pathology Reports

Tenosynovial giant cell tumor, also known as giant cell tumor of the tendon sheath (GCT-TS), is a solitary, nodular, firm, benign, soft-tissue tumor that arises from the synovial lining of a tendon. The etiology is unknown. It is a rare soft-tissue tumor, with an overall incidence of one in 50,000 individuals, and usually affects people aged between 30 and 50 years. Magnetic resonance imaging tends to be the imaging modality of choice, used for surgical preparation. Widely accepted treatment involves local excision with or without radiotherapy. The author presents a case study involving a patient with an abnormally large, longstanding GCT-TS, diagnosed with clinical examination and imaging modalities, surgically excised, and further confirmed by pathology reports. Topic of discussion includes a review of GCT-TS.

scholarly journals Giant Cell Tumor of Tendon Sheath of Great Toe

2017 ◽  
Vol 15 (2) ◽  
pp. 62-64
Author(s):  
Surya Bahadur Thapa ◽  
Bibek Banskota ◽  
Ashok Kumar Banskota
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Soft Tissue Tumor ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Great Toe ◽  
Extensor Hallucis Longus ◽  
Benign Soft Tissue Tumor ◽  
The Right

Introduction: Giant cell tumor of the tendon sheath is an uncommon benign soft tissue tumor of the tendon sheath and synovium usually affecting the middle aged population.  Only 3-10 % of Giant cell tumor of the tendon sheath occur on foot. Of them 5 - 10 % present with erosion of bone. We present a case of 30 years old male who had Giant cell tumor of the tendon sheath on the foot involving the Flexor Hallucis Longs  and Extensor Hallucis Longus and eroding both the phalanges of the right great toe.

scholarly journals Recurrence of Giant Cell Tumor of Posterior Tibialis Tendon

2017 ◽  
Vol 4 (1) ◽  
pp. 45-48
Author(s):  
Karan R Choudhry ◽  
Vishal N Mandlewala
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Asia Pacific ◽  
Tibialis Posterior ◽  
Medial Malleolus ◽  
Scar Mark

ABSTRACT Aim To present a case of recurrence of giant cell tumor of the tendon sheath (GCT TS) and its management. Background The GCT TS is a solitary benign soft tissue tumor of the limbs. It usually appears as an enlarging painless mass and has a synovial origin. The GCT TS is approximately 1.6% of all soft tissue tumors. The GCT TS of tibialis posterior is very rare, and recurrence has not been reported. Case report A 21-year-old male patient presents with complaint of swelling over right ankle since 3 years. Patient was operated for swelling 10 years back, and histological examination revealed GCT TS. Patient was asymptomatic for 3 years after operation and then developed swelling since last 3 years. On local examination, hypertrophic scar mark 1 × 4 cm was present at right medial malleolus. Ultrasonography of right medial malleolus and magnetic resonance imaging were done for further evaluation. Under spinal anesthesia and tourniquet control, medial approach was taken extending from 7 cm above the medial malleolus posterior to the tibia up to the talar head. Tissue was cleared and was sent for histopathology, which confirmed the diagnosis of GCT TS. Patient is on regular follow-up since then, and there has not been any recurrence. Conclusion Though rare, recurrence of GCT TS can occur, and it should be properly investigated and completely excised. Clinical significance Though recurrence of GCT TS is rarely reported, it needs to be dealt with a high index of suspicion and treated aggressively. How to cite this article Choudhry KR, Mandlewala VN. Recurrence of Giant Cell Tumor of Posterior Tibialis Tendon. J Foot Ankle Surg (Asia-Pacific) 2017;4(1):45-48.

scholarly journals ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT)

2020 ◽  
Vol 16 (25) ◽  
pp. 1875-1878 ◽  
Author(s):  
William Tap
Keyword(s):  
Side Effects ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Liver Function Tests ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Hair Color ◽  
Plain Language ◽  
Clinical Trial Registration ◽  
Tenosynovial Giant Cell Tumor

Pexidartinib is the first approved medication in the USA for people with tenosynovial giant cell tumor (TGCT). The drug was approved based on the ENLIVEN study, which looked at pexidartinib (brand name, Turalio™), a medication taken by mouth (orally) for people with TGCT (also known as giant cell tumor of the tendon sheath [GCTTS] and pigmented villonodular synovitis [PVNS]) who are not able to have surgery because of the location and/or the size of the tumor. The study showed that pexidartinib is effective in treating people with TGCT because it shrunk the size of their tumors and improved their symptoms and their ability to function. In general, people treated with pexidartinib had side effects that were mostly mild that went away after treatment with pexidartinib was stopped. The most common side effects were hair color changes and tiredness (fatigue). Pexidartinib was also associated with liver problems (or hepatotoxicity), which started within the first 2 months of treatment. Due to the risk of liver problems, which may be severe and potentially life threatening, the researchers closely monitored participants’ blood liver function tests before, during, and after participants in the study took pexidartinib. To read the full Plain Language Summary of this article, click on the View Article button above and download the PDF. Clinical Trial Registration: NCT02371369 ( ClinicalTrials.gov )

Rare Intramuscular Lipoma of the Foot: A Case Report

2021 ◽  
Vol 111 (3) ◽  
Author(s):  
Peter Awad
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Imaging Modality ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Tissue Tumor ◽  
Intramuscular Lipoma ◽  
Surgical Preparation ◽  
Pathology Reports

Intramuscular lipoma is a rare subset of a more common soft-tissue tumor, lipoma. The etiology is unknown. It is a rare soft-tissue tumor with an overall incidence of less than 1% of all lipomas. Magnetic resonance imaging tends to be the imaging modality of choice, used for surgical preparation. Widely accepted treatment involves local excision. The author presents a case study involving a patient with an abnormally large, recurrent intramuscular lipoma of the left hallux, surgically excised and confirmed by pathology reports. iscussion includes a review of intramuscular lipoma. A review of the literature revealed only two previous reports.

Pediatric Tenosynovial Giant Cell Tumor of the Flexor Hallucis Longus Tendon Sheath

2020 ◽  
Vol 10 (2) ◽  
pp. e0519-e0519
Author(s):  
Richard D. Williams ◽  
M. Wesley Honeycutt ◽  
Elizabeth A. Manci ◽  
Prasit Nimityongskul
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Flexor Hallucis Longus ◽  
Longus Tendon ◽  
Tenosynovial Giant Cell Tumor

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

2000 ◽  
Vol 44 (3) ◽  
pp. 463-466 ◽  
Author(s):  
Monisha Choudhury ◽  
Renu Jain ◽  
Anita Nangia ◽  
K.B. Logani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Tenosynovial Giant Cell Tumor

scholarly journals Management of a Huge Tenosynovial Giant Cell Tumor of the Wrist

2021 ◽  
Author(s):  
Woo Jong Kim ◽  
Sang Mi Lee ◽  
Byungsung Kim ◽  
Jae-Hwi Nho ◽  
Jun Bum Kim ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rare Case ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Benign Neoplasms ◽  
Diffuse Type ◽  
Giant Cell Tumors ◽  
Tenosynovial Giant Cell Tumor

Tenosynovial giant cell tumors (TGCTs) are typically benign neoplasms of the joint, bursa, and tendon sheath. Usually, TGCT presents as a small localized tumor on the hand and wrist. The diffuse-type TGCT is more aggressive and mainly affects large joints such as knees, hips, ankles, and elbows. Diffuse-type TGCT of small joints is rare. To our knowledge, this is a very rare case of a huge diffuse-type TGCT on the wrist. We report a huge TGCT, which grew gradually over 10 years.

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