A Prospective, Randomized, Double-blinded Study with Crossover to Determine the Efficacy of Radio-frequency Nerve Ablation for the Treatment of Heel Pain

2013 ◽  
Vol 103 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Adam S. Landsman ◽  
Dominic J. Catanese ◽  
Steven N. Wiener ◽  
Douglas H. Richie ◽  
Jason R. Hanft
Keyword(s):  
Radio Frequency ◽  
Randomized Study ◽  
Treated Group ◽  
Pain Scale ◽  
Heel Pain ◽  
Visual Analog Pain Scale ◽  
Sham Treatment ◽  
Blinded Study ◽  
Average Pain ◽  
Double Blinded

Background: Previous studies have demonstrated that radio-frequency nerve ablation (RFNA) can be an effective treatment for plantar fasciosis. This study provides additional evidence in support of this treatment, with statistically significant data that demonstrate the success of this technique. Methods: In this multicenter, randomized, prospective, double-blinded study with crossover, 17 patients were divided into two groups, with eight initially receiving RFNA treatment and nine initially receiving sham treatment. If no improvement was observed after 4 weeks, a crossover was offered. Results of the treatment were evaluated by the patient and by a blinded physician using a visual analog pain scale to rate first-step pain, average pain, and peak pain in the heel region. Results: We observed a statistically significant improvement in the symptoms of plantar fasciosis in patients actively treated with RFNA and no significant improvement in the sham-treated group. More important, those treated with sham subsequently demonstrated statistically significant improvement after subsequent RFNA treatment. Conclusions: Using a prospective, randomized study with sham treatment and crossover, this study demonstrates the efficacy of RFNA for the treatment of plantar fasciosis. (J Am Podiatr Med Assoc 103(1): 8–15, 2013)

The New Use of an Ancient Remedy: A Double-Blinded Randomized Study on the Treatment of Rheumatoid Arthritis

2013 ◽  
Vol 41 (02) ◽  
pp. 263-280 ◽  
Author(s):  
Letian Chen ◽  
Haiyu Qi ◽  
Dezhen Jiang ◽  
Renshuo Wang ◽  
Aidong Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Randomized Study ◽  
Chronic Inflammatory Disease ◽  
Onset Of Action ◽  
End Point ◽  
American College Of Rheumatology ◽  
Significant Difference ◽  
Blinded Study ◽  
Maximum Improvement ◽  
Double Blinded

Rheumatoid arthritis (RA) is the most common chronic inflammatory disease with unknown causes and unknown cures in Western medicine. This double-blinded study aimed to investigate the efficacy and safety of a widely used traditional Chinese medicine (Paeoniflorin (PAE) plus cervus and cucumis polypeptide injection (CCPI) using disease-modifying antirheumatic drugs (DMARD) as a control (methotrexate (MTX) plus leflunomide (LEF)). Patients were randomly assigned to one of the three groups: PAE + CCPI, MTX + LEF, and MTX + LEF + CCPI. The primary end point was the American College of Rheumatology 20% improvement response criteria (ACR20). The secondary end point was that of adverse effect frequencies and the speed of onset action. Our results showed that more patients in the CCPI-containing groups responded to the ACR20 during early treatment. After six months, ACR20 showed no significant difference among the three treatments. The maximum improvement in the two DMARD groups was significantly higher than that in the PAE + CCPI group (p < 0.01). CCPI made the onset action of the DMARD therapy 4.6 times faster. PAE + CCPI had significantly lower adverse event incidences than the two DMARD groups. These results indicate that PAE + CCPI appear to be a more acceptable alternative to DMARDs when patients cannot use DMARDs. CCPI appears to be a beneficial add-on to DMARDs that makes the onset of action faster, especially when patients need to relieve RA symptoms as soon as possible. Although not as effective as DMARDs, PAE appears to be a safer option to substitute DMARDs for long-term RA treatment when DMARD toxicity is an issue.

Results of a Randomized Study of IM862 Nasal Solution in the Treatment of AIDS-Related Kaposi’s Sarcoma

2000 ◽  
Vol 18 (4) ◽  
pp. 716-716 ◽  
Author(s):  
Anil Tulpule ◽  
David T. Scadden ◽  
Byron M. Espina ◽  
Suzanne Cabriales ◽  
Walter Howard ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Kaposi's Sarcoma ◽  
Systemic Chemotherapy ◽  
Randomized Study ◽  
Kaposi’S Sarcoma ◽  
Days Of Therapy ◽  
Blinded Study ◽  
Male Patients ◽  
Double Blinded ◽  
Unacceptable Toxicity

PURPOSE: Although advances have been made in the treatment of AIDS-related Kaposi’s sarcoma (AIDS-KS) with systemic chemotherapy, less toxic therapies are needed. IM862 is a naturally occurring peptide with antiangiogenic properties and was thus studied in patients with AIDS-KS. PATIENTS AND METHODS: IM862 was given as intranasal drops at a dose of 5 mg. Patients were randomized to two dosing schedules given in repeated cycles until disease progression or unacceptable toxicity: 5 days of therapy followed by 5 days off (n = 18) and every other day dosing (n = 26). RESULTS: Forty-two male patients and two female patients with a median age of 38 years (range, 22 to 53 years) were accrued. Twenty-one patients (47%) had more than 50 mucocutaneous lesions, 14 (32%) had lymphedema, and none had visceral involvement. Thirty-three patients (75%) had received prior systemic chemotherapy. Twenty-four patients (55%) had CD4+ lymphocyte count ≤ 200/mm3. All but five patients were being treated with concurrent protease inhibitor(s), for a median of 10 months (range, 0 to 24 months). Major responses were documented in 36%, with five complete and 11 partial remissions, occurring after a median of 6 weeks (range, 3 to 26 weeks) and lasting a median of 33+ weeks (range, 12+ to 95+ weeks). Twenty-one patients had stable disease for periods of 7 to 72+ weeks. Adverse effects to IM862 were limited to mild and transient headache, fatigue, tingling, and nausea. No hematologic adverse effects attributed to treatment were reported. CONCLUSION: IM862 given as intranasal drops is well tolerated and has antitumor activity in patients with AIDS-KS. A randomized double-blinded study to define the activity of IM862 in patients with AIDS-KS is in progress.

scholarly journals The Effects of Intravenous Fosaprepitant and Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Neurosurgery Patients: A Prospective, Randomized, Double-Blinded Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yasuo M. Tsutsumi ◽  
Nami Kakuta ◽  
Tomohiro Soga ◽  
Katsuyoshi Kume ◽  
Eisuke Hamaguchi ◽  
...  
Keyword(s):  
Postoperative Nausea ◽  
Randomized Study ◽  
Postoperative Nausea And Vomiting ◽  
Complete Response ◽  
Nausea And Vomiting ◽  
Nk1 Receptor Antagonist ◽  
Blinded Study ◽  
Neurokinin 1 ◽  
Double Blinded ◽  
To Receive

The incidence of postoperative nausea and vomiting (PONV) is 30–50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, or ondansetron intravenously. Sixty-four patients undergoing craniotomy were randomly allocated to receive fosaprepitant 150 mg i.v. (NK1 group,n= 32) or ondansetron 4 mg i.v. (ONS group,n= 32) before anesthesia. The incidence of vomiting was significantly less in the NK1 group, where 2 of 32 (6%) patients experienced vomiting compared to 16 of 32 (50%) patients in the ONS group during the first 24 and 48 hours following surgery. Additionally, the incidence of complete response (no vomiting and no rescue antiemetic use) was significantly higher in the NK1 group than in the ONS group, and was 66% versus 41%, respectively, during the first 24 hours, and 63% versus 38%, respectively, during the first 48 hours. In patients undergoing craniotomy, fosaprepitant is more effective than ondansetron in increasing the rate of complete response and decreasing the incidence of vomiting at 24 and 48 hours postoperatively.

scholarly journals COMPARISON OF ORAL CLONIDINE WITH ORAL MIDAZOLAM IN MANAGING AGITATION FOLLOWING SEVOFLURANE ANESTHESIA – A PROSPECTIVE, RANDOMIZED, DOUBLE BLINDED STUDY

2016 ◽  
Vol 9 (6) ◽  
pp. 297
Author(s):  
Antony John Charles S ◽  
Raghuraman M S ◽  
Raji Sharma ◽  
David George Veliath
Keyword(s):  
Pain Scale ◽  
Emergence Agitation ◽  
Remarkable Change ◽  
Oral Clonidine ◽  
Anesthetic Agents ◽  
Post Operative Period ◽  
Group I ◽  
Oral Midazolam ◽  
Blinded Study ◽  
Double Blinded

ABSTRACT:Objective: Emergence agitation is a major problem during recovery from anesthetic agents like sevoflurane, particularly in children. This study had compared the effects of oral clonidine with oral midazolam in reducing the incidence of emergence agitation following sevoflurane anesthesia.Methods: 50 children of ASA status I and II aged between 3-8 years were randomly allotted to one of the two groups, each group comprising 25 children. Group I children were given oral Midazolam 0.5 mg/kg and Group II children were given oral Clonidine 4 mcg/kg 30 min before the induction of anesthesia. Emergence reaction was analyzed using modified objective pain scale in all children following sevoflurane administration.Results: The total agitation score was significantly less in clonidine group in comparison to midazolam group during the first hour of post operative period (P<0.05).No remarkable change in the hemodynamics or oxygen saturation was observed in both groups.Conclusion: Premedication of oral clonidine 4 microgram per kg is superior to oral midazolam 0.5 mg per kg in reducing the incidence of emergence agitation following sevoflurane anesthesia.Keywords: sevoflurane, recovery, emergence agitation, clonidine, midazolam.

scholarly journals An Open Randomized Trial Comparing the Effects of Oral NSAIDs Versus Steroid Intra-Articular Infiltration in Congestive Osteoarthritis of the Knee

2016 ◽  
Vol 10 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Ouédraogo Dieu-Donné ◽  
Ouédraogo Théodore ◽  
Zabsonré/Tiendrébéogo Joëlle ◽  
Dionou Pierre ◽  
Ouédraogo Smaïla ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Pain Intensity ◽  
Randomized Study ◽  
Pain Scale ◽  
Osteoarthritis Of The Knee ◽  
Spontaneous Pain ◽  
Average Intensity ◽  
Average Pain Intensity ◽  
Average Pain ◽  
Weekly Assessment

Objective: To compare the efficacy on pain and joint function of NSAIDs versus steroid intra-articular infiltration in congestive knee osteoarthritis. Patients and Methods: Open randomized study comparing a series of patients treated with NSAIDs for 21 days and another who received steroid intra-articular infiltration (SIAI) spaced at every 7 days. The visual analog scale was used for the weekly assessment of spontaneous pain and pain when walking. Lequesne functional pain scale was used to assess the functional impact of knee osteoarthritis. Results: Seventy patients were enrolled, including 35 in the NSAID arm and 35 in SIAI arm. Forty-nine (70%) had stage III of Kellgren and Lawrance scale. On admission, the average pain intensity was 50.46 ± 30.93 in the NSAID arm and 60.92 ± 30 in SIAI arm (p = 0.0189). At the end of follow-up, pain intensity was 6.72 ± 13 in NSAIDs patients and 17.80 ± 21 in SIAI one (p = 0.001). The average intensity of pain on walking was 64.41 ± 22.61. It was 53.33 ± 22.31 in NSAID’s against 74.85 ± 17.55 in SIAI patients (P <0.0001). At the end of the treatment, they were respectively 19.11 ± 11.37, and 35 ± 30.69 (P = 0.0085). Conclusion: Corticosteroid injections have a short efficacy compared to NSAIDs. Prescribing NSAIDs should consider the cons-indications, comorbidities and their deleterious digestive, renal, and cardiovascular effect.

Sign in / Sign up

Export Citation Format

Share Document