Mortality Rates and Diabetic Foot Ulcers

2008 ◽  
Vol 98 (6) ◽  
pp. 489-493 ◽  
Author(s):  
Jeffrey M. Robbins ◽  
Gerald Strauss ◽  
David Aron ◽  
Jodi Long ◽  
Jennifer Kuba ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Mortality Rates ◽  
Lower Extremity Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Preventive Interventions ◽  
Improve Life Expectancy ◽  
Vulnerable Patient ◽  
Extremity Amputation ◽  
New Onset

Five-year mortality rates after new-onset diabetic ulceration have been reported between 43% and 55% and up to 74% for patients with lower-extremity amputation. These rates are higher than those for several types of cancer including prostate, breast, colon, and Hodgkin’s disease. These alarmingly high 5-year mortality rates should be addressed more aggressively by patients and providers alike. Cardiovascular diseases represent the major causal factor, and early preventive interventions to improve life expectancy in this most vulnerable patient cohort are essential. New-onset diabetic foot ulcers should be considered a marker for significantly increased mortality and should be aggressively managed locally, systemically, and psychologically. (J Am Podiatr Med Assoc 98(6): 489–493, 2008)

scholarly journals Risk factors for lower extremity amputation in patients with diabetic foot ulcers: a hospital-based case–control study

2015 ◽  
Vol 6 (1) ◽  
pp. 29629 ◽  
Author(s):  
Tjokorda Gde Dalem Pemayun ◽  
Ridho M. Naibaho ◽  
Diana Novitasari ◽  
Nurmilawati Amin ◽  
Tania Tedjo Minuljo
Keyword(s):  
Risk Factors ◽  
Lower Extremity ◽  
Diabetic Foot ◽  
Case Control Study ◽  
Case Control ◽  
Lower Extremity Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Extremity Amputation ◽  
Control Study

Diabetes mellitus. Prevention of amputation

1994 ◽  
Vol 84 (7) ◽  
pp. 322-328 ◽  
Author(s):  
LJ Sanders
Keyword(s):  
At Risk ◽  
Lower Extremity ◽  
Diabetic Foot ◽  
Lower Extremity Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Medical Care Costs ◽  
External Forces ◽  
Care Costs ◽  
Extremity Amputation

Fifteen percent of individuals with diabetes will likely develop foot ulcers in their lifetime, and approximately 15% to 20% of these ulcers are estimated to result in lower extremity amputation. Techniques to prevent lower extremity amputation range from the simple but often neglected foot inspection to complicated vascular and reconstructive foot surgery. Appropriate management can prevent and heal diabetic foot ulcers, thereby greatly decreasing the amputation rate and medical care costs. Prevention is the key to treatment. The author discusses general guidelines for foot screening and identifies three specific goals for prevention of amputation: 1) identification of at risk individuals needing prevention and the specific factors placing them at risk; 2) protection of the foot against the adverse effects of external forces (pressure, friction, and shear); and 3) reduction of the incidence of diabetic foot ulcers through educational programs.

scholarly journals Current Therapeutic Strategies in Diabetic Foot Ulcers

Medicina ◽  
2019 ◽  
Vol 55 (11) ◽  
pp. 714 ◽  
Author(s):  
Perez-Favila ◽  
Martinez-Fierro ◽  
Rodriguez-Lazalde ◽  
Cid-Baez ◽  
Zamudio-Osuna ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Diabetic Foot ◽  
Treatment Strategies ◽  
Arterial Disease ◽  
Current Treatment ◽  
Lower Extremity Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Peripheral Arterial ◽  
Extremity Amputation

Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.

scholarly journals The Influence of Multidrug-Resistant Bacteria on Clinical Outcomes of Diabetic Foot Ulcers: A Systematic Review

2021 ◽  
Vol 10 (9) ◽  
pp. 1948
Author(s):  
Gianmarco Matta-Gutiérrez ◽  
Esther García-Morales ◽  
Yolanda García-Álvarez ◽  
Francisco Javier Álvaro-Afonso ◽  
Raúl Juan Molines-Barroso ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Diabetic Foot ◽  
Mortality Rates ◽  
Multidrug Resistant ◽  
Healing Time ◽  
Cochrane Library ◽  
Foot Ulcers ◽  
Resistant Organism ◽  
Diabetic Foot Ulcers ◽  
Multidrug Resistant Organisms

Multidrug-resistant organism infections have become important in recent years due to the increased prevalence of diabetic foot ulcers and their possible consequences. This study aimed to systematically review and evaluate ulcer duration, healing time, hospital stay, amputation, and mortality rates in patients with diabetic foot ulcers caused by infection with multidrug-resistant organisms. PubMed, the Cochrane Library, and Web of Science were searched in May 2020 to find observational studies in English about the clinical outcomes of multidrug-resistant organism infection in diabetic foot ulcers. Eight studies met the inclusion criteria, and these studies included 923 patients. The overall methodological quality of the study was moderate. Ulcer duration was described in six studies, and there was no practical association with multidrug-resistant organisms. Two out of three studies reported a longer healing time in multidrug-resistant organism infections than in non-multidrug-resistant organism infections. Clinical outcomes included the duration of hospitalisation, surgeries, amputations, and deaths. Lower limb amputation was the most reported clinical outcome in the included studies, and was more prevalent in the multidrug-resistant organism infections. We concluded that there was not enough evidence that multidrug-resistant organisms hindered the healing of diabetic foot ulcers. In contrast to the clinical outcomes, multidrug-resistant organisms affect both amputation rates and mortality rates.

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