A Critical Discussion of the Use of Antiseptics in Acute Traumatic Wounds

2005 ◽  
Vol 95 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Robert G. Smith
Keyword(s):  
Patient Outcome ◽  
Cell Culture ◽  
Wound Healing ◽  
Case Studies ◽  
Emergency Departments ◽  
Current Practice ◽  
Human Case ◽  
Critical Discussion ◽  
Scientific Study ◽  
Potential Harm

Approximately 10 million patients with traumatic wounds are treated in US emergency departments annually. The practice of wound cleansing or antiseptic management has a dichotomous history anchored in tradition and science. The merits of antiseptic fluid irrigation of traumatic wounds have received little scientific study. The purpose of this article is to critically evaluate the potential harm to patient outcome by the use of antiseptics on acute wounds. First, animal and cell culture data that describe the effects of topical antiseptics on wound healing are offered. Second, human case studies are presented to illustrate the potential harm of the indiscriminate use of antiseptics. Finally, data from previously published reviews are presented and evaluated for clinically based evidence to justify the current practice of antiseptic use in acute traumatic wounds. (J Am Podiatr Med Assoc 95(2): 148–153, 2005)

A renewed look at silver dressings for wound infections: Ag Oxysalts technology

2021 ◽  
Vol 26 (Sup9) ◽  
pp. S26-S36
Author(s):  
Luxmi Dhoonmoon ◽  
Hayley Turner-Dobbin ◽  
Karen Staines
Keyword(s):  
Wound Healing ◽  
Wound Infection ◽  
Case Studies ◽  
Healing Process ◽  
Systemic Toxicity ◽  
Wound Healing Process ◽  
Wound Infections ◽  
Infected Wounds ◽  
Long Time

Wound infection is an important complicating factor in the wound healing process, and infections can be even more complex and difficult to manage in the case of wounds with biofilms. Silver has been used to treat infected wounds for a long time now, and the strength of the product depends on the number of Ag ions, where the greater the number of ions, the higher and faster the reactivity is. Ag Oxysalts technology—used in 3M Kerracontact Ag dressing—has three times more ions than standard silver dressings. The technology also does not show the typical disadvantages of silver, such as cytotoxicity and systemic toxicity. This article discusses the use of Ag Oxysalts technology for infected wounds and presents case studies to support the efficacy of this product in promoting wound healing.

scholarly journals St. Louis encephalitis vírus: first isolation from a human in São Paulo state, Brasil

2005 ◽  
Vol 47 (5) ◽  
pp. 281-285 ◽  
Author(s):  
Iray M. Rocco ◽  
Cecília L.S. Santos ◽  
Ivani Bisordi ◽  
Selma M.C.N. Petrella ◽  
Luiz E. Pereira ◽  
...  
Keyword(s):  
Cell Culture ◽  
Human Case ◽  
Sao Paulo ◽  
Encephalitis Virus ◽  
Cell Culture Supernatant ◽  
São Paulo ◽  
Rt Pcr ◽  
Igg Antibody ◽  
Paulo State ◽  
São Paulo State

This paper reports the isolation of St. Louis encephalitis virus (SLEV) from a febrile human case suspected to be dengue, in São Pedro, São Paulo State. A MAC-ELISA done on the patient's acute and convalescent sera was inconclusive and hemagglutination inhibition test detected IgG antibody for flaviviruses. An indirect immunofluorescent assay done on the C6/36 cell culture inoculated with the acute serum was positive for flaviviruses but negative when tested with dengue monoclonal antibodies. RNA extracted from the infected cell culture supernatant was amplified by RT-PCR in the presence of NS5 universal flavivirus primers and directly sequenced. Results of BLAST search indicated that this sequence shares 93% nucleotide similarity with the sequence of SLEV (strain-MSI.7), confirmed by RT-PCR performed with SLEV specific primers. Since SLEV was identified as the cause of human disease, it is necessary to improve surveillance in order to achieve early detection of this agent in the state of São Paulo and in Brazil. This finding is also an alert to health professionals about the need for more complete clinical and epidemiological investigations of febrile illnesses as in the reported case. SLEV infections can be unrecognized or confused with other ones caused by an arbovirus, such as dengue.

Pain management in Australian emergency departments: Current practice, enablers, barriers and future directions

2011 ◽  
Vol 24 (2) ◽  
pp. 136-143 ◽  
Author(s):  
Scott Bennetts ◽  
Evylyn Campbell-Brophy ◽  
Susan Huckson ◽  
Steven Doherty ◽  
Keyword(s):  
Pain Management ◽  
Emergency Departments ◽  
Current Practice ◽  
Future Directions

scholarly journals Designing and evaluating an automated system for real-time medication administration error detection in a neonatal intensive care unit

2018 ◽  
Vol 25 (5) ◽  
pp. 555-563 ◽  
Author(s):  
Yizhao Ni ◽  
Todd Lingren ◽  
Eric S Hall ◽  
Matthew Leonard ◽  
Kristin Melton ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Real Time ◽  
Medication Errors ◽  
Neonatal Intensive Care ◽  
Current Practice ◽  
Medication Administration ◽  
Automated System ◽  
Patient Exposure ◽  
Potential Harm

Abstract Background Timely identification of medication administration errors (MAEs) promises great benefits for mitigating medication errors and associated harm. Despite previous efforts utilizing computerized methods to monitor medication errors, sustaining effective and accurate detection of MAEs remains challenging. In this study, we developed a real-time MAE detection system and evaluated its performance prior to system integration into institutional workflows. Methods Our prospective observational study included automated MAE detection of 10 high-risk medications and fluids for patients admitted to the neonatal intensive care unit at Cincinnati Children’s Hospital Medical Center during a 4-month period. The automated system extracted real-time medication use information from the institutional electronic health records and identified MAEs using logic-based rules and natural language processing techniques. The MAE summary was delivered via a real-time messaging platform to promote reduction of patient exposure to potential harm. System performance was validated using a physician-generated gold standard of MAE events, and results were compared with those of current practice (incident reporting and trigger tools). Results Physicians identified 116 MAEs from 10 104 medication administrations during the study period. Compared to current practice, the sensitivity with automated MAE detection was improved significantly from 4.3% to 85.3% (P = .009), with a positive predictive value of 78.0%. Furthermore, the system showed potential to reduce patient exposure to harm, from 256 min to 35 min (P < .001). Conclusions The automated system demonstrated improved capacity for identifying MAEs while guarding against alert fatigue. It also showed promise for reducing patient exposure to potential harm following MAE events.

scholarly journals General practitioners and emergency departments (GPED)—efficient models of care: a mixed-methods study protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e024012
Author(s):  
Katherine Morton ◽  
Sarah Voss ◽  
Joy Adamson ◽  
Helen Baxter ◽  
Karen Bloor ◽  
...  
Keyword(s):  
Emergency Department ◽  
Case Studies ◽  
General Practitioners ◽  
Emergency Departments ◽  
Quantitative Methods ◽  
Public Involvement ◽  
Clinical Care ◽  
Urgent Care ◽  
The Uk ◽  
The Impact

IntroductionPressure continues to grow on emergency departments in the UK and throughout the world, with declining performance and adverse effects on patient outcome, safety and experience. One proposed solution is to locate general practitioners to work in or alongside the emergency department (GPED). Several GPED models have been introduced, however, evidence of effectiveness is weak. This study aims to evaluate the impact of GPED on patient care, the primary care and acute hospital team and the wider urgent care system.Methods and analysisThe study will be divided into three work packages (WPs). WP-A; Mapping and Taxonomy: mapping, description and classification of current models of GPED in all emergency departments in England and interviews with key informants to examine the hypotheses that underpin GPED. WP-B; Quantitative Analysis of National Data: measurement of the effectiveness, costs and consequences of the GPED models identified in WP-A, compared with a no-GPED model, using retrospective analysis of Hospital Episode Statistics Data. WP-C; Case Studies: detailed case studies of different GPED models using a mixture of qualitative and quantitative methods including: non-participant observation of clinical care, semistructured interviews with staff, patients and carers; workforce surveys with emergency department staff and analysis of available local routinely collected hospital data. Prospective case study sites will be identified by completing telephone interviews with sites awarded capital funding by the UK government to implement GPED initiatives. The study has a strong patient and public involvement group that has contributed to study design and materials, and which will be closely involved in data interpretation and dissemination.Ethics and disseminationThe study has been approved by the National Health Service East Midlands—Leicester South Research Ethics Committee: 17/EM/0312. The results of the study will be disseminated through peer-reviewed journals, conferences and a planned programme of knowledge mobilisation.Trial registration numberISRCTN51780222.

scholarly journals Imitate: Remediating Glass as an Artistic Medium for Material Imitation

Arts ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 30
Author(s):  
Jessamy Kelly
Keyword(s):  
Case Studies ◽  
Current Practice ◽  
Material Testing ◽  
Artistic Practice ◽  
Practice Based Research ◽  
Artistic Medium ◽  
Unique Ability ◽  
Precious Stones

Glass has a unique ability to imitate other materials; cross-pollinating with other disciplines to refresh and recreate itself. The creative possibilities of creating glass that imitates other materials such as ceramic, paper, metal, wood, stone, plastic and semi-precious stones are vast. The assertion of this paper is that the use of imitation is a necessary and definitive act within creative artistic practice. Following a range of historical examples to set the context for this article, a range of contemporary glass artists that use glass as a medium for imitation will be introduced and documented through a series of artists case studies. Finally, I will present my current practice-based research into glass as a medium for imitation. I will discuss the material testing and research that has been carried out and introduce two new bodies of artworks that I have developed based on the theme of glass as an artistic medium for material imitation.

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