scholarly journals Fluindione and cefixime induced cutaneous bleeding manifestations –A case report and review of literature

2018 ◽  
Vol 8 (3) ◽  
pp. 24
Author(s):  
Nishanthi Anandabaskar ◽  
Nalinidevi Jayabalan ◽  
Mohanasundaram Jayaraman ◽  
Meher Ali Rajamohammad
Keyword(s):  
Drug Interaction ◽  
Oral Anticoagulant Therapy ◽  
Lower Limbs ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
Oral Vitamin ◽  
Periodic Monitoring ◽  
Life Threatening ◽  
Upper Respiratory ◽  
Rheumatic Heart

Fluindione an oral vitamin K antagonist is associated with various hemorrhagic and immunoallergic effects. This drug is also prone to produce various drug interactions, which if not taken into consideration while prescribing, might lead to increased incidence of adverse drug reactions for the patients. We report a case of drug interaction between fluindione and cefixime leading to cutaneous bleeding manifestations and raised PT-INR. Our patient was a 59 year old lady, a known case of rheumatic heart disease and mitral valve replacement, on tablet fluindione 20 mg for past 11 years. She was prescribed tablet cefixime 200 mg two times a day for three days for treatment of upper respiratory tract infection, following which she developed cutaneous bleeding manifestations like ecchymosis and purpura in left upper and lower limbs. She also had a rise in PT-INR level to 4.2, predisposing the patient to life threatening bleeding manifestations. Hence, caution is warranted while prescribing antibiotics to patients on oral anticoagulant therapy. Antibiotics that do not cause drug interaction with the anticoagulants must be selected in these patients. Also, periodic monitoring of PT INR in patients on anticoagulants especially when a new drug is co-prescribed is essential to curb the hazards of potential adverse drug interaction.

FEATURES OF RESIDUAL PHENOMENA AND CONSEQUENCES OF COVID-19 (REVIEW)

Vestnik ◽  
2021 ◽  
pp. 335-340
Author(s):  
Г.Н. Абуова ◽  
Г.А. Айтмуратова ◽  
Т.В. Полукчи ◽  
Ф.А. Бердалиева ◽  
Г.Г. Шаймерденова
Keyword(s):  
Asymptomatic Infection ◽  
Multiple Organ ◽  
Upper Respiratory Tract ◽  
Respiratory Tract Disease ◽  
Infected People ◽  
Life Threatening ◽  
Upper Respiratory ◽  
Tract Disease ◽  
Timely Treatment

Проведен литературный обзор об особенностях остаточных явлений и последствий COVID-19 на основе данных, опубликованных до настоящего времени. К началу января 2021 года COVID-19, сопровождающийся тяжелым острым респираторным синдромом, вызванным коронавирусом (SARS-CoV-2), привел к более чем 83 миллионам подтвержденных случаев и более чем 1,8 миллионам смертей. Клинический спектр инфекции SARS-CoV-2 широк, включая бессимптомную инфекцию, лихорадку, усталость, миалгии, легкое заболевание верхних дыхательных путей, тяжелую и опасную для жизни вирусную пневмонию, требующую госпитализации и летальный исход. COVID-19 - это новое заболевание, и остается неопределенность в отношении возможных долгосрочных последствий для здоровья. На сегодняшний день известно, что у большинства инфицированных, особенно в молодом возрасте, заболевание имеет легкое течение, по сравнению с лицами старшего возраста. У некоторых пациентов заболевание быстро прогрессирует и развиваются различные осложнения, в т.ч. полиорганная недостаточность. Поэтому раннее выявление и своевременное лечение критических случаев имеет решающее значение. A literature review on the features of residual phenomena and consequences of COVID-19 is analyzed on the basis of data published so far. By the beginning of January 2021, COVID-19, accompanied by severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2), led to more than 83 million confirmed cases and more than 1.8 million deaths. The clinical spectrum of SARS-CoV-2 infection is wide, including asymptomatic infection, fever, fatigue, myalgia, mild upper respiratory tract disease, severe and life-threatening viral pneumonia requiring hospitalization, and death. COVID-19 is a new disease, and uncertainty remains about possible long-term health consequences. To date, it is known that the majority of infected people, especially at a young age, have a mild course of the disease, compared with older people. In some patients, the disease progresses rapidly and various complications develop, including multiple organ failure. Therefore, early detection and timely treatment of critical cases is crucial.

scholarly journals Challenges in the delivery of critical care in India during the COVID-19 pandemic

2020 ◽  
pp. 175114372095259
Author(s):  
Bharath Kumar Tirupakuzhi Vijayaraghavan ◽  
Sheila Nainan Myatra ◽  
Meghena Mathew ◽  
Nirmalyo Lodh ◽  
Jigeeshu Vasishtha Divatia ◽  
...  
Keyword(s):  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Intensive Care ◽  
Respiratory Tract ◽  
Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Upper Respiratory Tract ◽  
Care Services ◽  
Life Threatening ◽  
Upper Respiratory

Coronavirus disease 2019 cases in India continue to increase and are expected to peak over the next few weeks. Based on some projection models, India is expected to have more than 10 million cases by September 2020. The spectrum of disease can vary from mild upper respiratory tract symptoms to life-threatening acute respiratory distress syndrome and multi-organ failure requiring intensive care. Even if less than 5% of patients require critical care services, this will still rapidly overwhelm the healthcare system in a country, where intensive care services and resources are scarce and unevenly distributed. In this perspective article, we highlight the critical care preparedness of India for the pandemic and the associated challenges.

scholarly journals Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Ryan Leibrandt ◽  
Kenneth Angelino ◽  
Monique Vizel-Schwartz ◽  
Ilan Shapira
Keyword(s):  
Respiratory Syncytial Virus ◽  
Upper Respiratory Tract ◽  
Rare Entity ◽  
Rare Form ◽  
Cold Temperatures ◽  
Tertiary Syphilis ◽  
Life Threatening ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Paroxysmal Cold Hemoglobinuria

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. The Donath–Landsteiner (DL) test, the diagnostic test for PCH, was positive on two separate occasions. The patient was treated successfully with warming and avoidance of cold temperatures. To facilitate identification of this rare entity by clinicians, we include a discussion about the pathophysiology, diagnosis, and treatment of PCH.

scholarly journals Haemophilus influenzae Pyomyositis in a Patient with Diabetic Ketoacidosis: A Unique Case and Review of Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Kamolyut Lapumnuaypol ◽  
Sanna Fatima ◽  
Pradhum Ram ◽  
Gemlyn George ◽  
Antoinette Climaco
Keyword(s):  
Haemophilus Influenzae ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Soft Tissue Infections ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
Unique Case ◽  
Negative Bacillus ◽  
Upper Respiratory ◽  
Tract Infections

Haemophilus influenzae is a Gram-negative bacillus commonly known to cause upper respiratory tract infections. Skin and soft tissue infections are very uncommon. Of these, the majority were associated with necrotizing fasciitis requiring emergent debridement. We report a case of pyomyositis caused by Haemophilus influenzae in an adult with diabetes.

scholarly journals Two Different Life-Threatening Cases: Presenting with Torticollis

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Gülsüm Alkan ◽  
Melike Emiroğlu ◽  
Ayşe Kartal
Keyword(s):  
Respiratory Tract ◽  
Arachnoid Cyst ◽  
Upper Respiratory Tract ◽  
Cervical Muscles ◽  
Common Causes ◽  
Inflammatory Processes ◽  
Life Threatening ◽  
Spinal Arachnoid Cyst ◽  
Upper Respiratory

Acquired torticollis can be the result of several different pathological mechanisms. It is generally related to trauma, tumors, and inflammatory processes of the cervical muscles, nerves, and vertebral synovia. Although upper respiratory tract and neck inflammation are common causes of acute febrile torticollis in children, diseases with as yet undefined relationships may also result in torticollis. This is the case of spinal arachnoid cyst and pneumonia.

scholarly journals Acute viral myositis: case report

2021 ◽  
Author(s):  
Felipe Sarlo Pezzin ◽  
Camila de Melo Perovani ◽  
Luana Marques Ribeiro ◽  
Julya Leite de Assis Pereira ◽  
Caroline Lopes Gratival ◽  
...  
Keyword(s):  
Case Report ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Nasal Congestion ◽  
Upper Respiratory Tract Infection ◽  
Lower Limbs ◽  
Neurological Deficits ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

Context: Benign Acute Childhood Myositis (BACM) is a self-limited syndrome of acute myalgia prevalent in calf with impaired walking after Upper Respiratory Tract Infection. This report analyze the clinical condition and investigation of BACM case, by medical record. Case report: C.L.F.A., male, 12 years, in use of clobazam, sodium divalproate, topiramate and lamotrigine, started low back pain. One day after, presented headache, fever and nasal congestion. Reported convulsive febrile episodes. At following morning received Upper Respiratory Tract Infection diagnoses. Next day, maintained symptoms and developed thrombocytopenia. Discharged due to suspicion of dengue. After 24 hours, returned with improved thrombocytopenia, also with leukopenia. At 5th day, started pain in lower limbs and impaired walking. Due to muscle symptoms worsening and increased creatinophosphokinase, hospital admission were indicated. Laboratory tests found increased in creatinekinase (10,180 U/L), CKMB (129,6 U/L), leukopenia (2800/mm3 ) and thrombocytopenia (174,000 / mm3 ). Anti-HIV, anti- leptospirosis, dengue, Chikungunya and anti-HCV tests resulted negative. At the 6th hospitalization day, he was discharged virtue of muscle symptoms, leukocytosis and creatinekinase levels favorable progression. Conclusions: BACM has excellent prognosis and self-limited course, so outpatient care is feasible. The diagnosis is clinical. If neurological deficits, modified urine tests and rash, or symptoms duration longer than one week, differential diagnoses must be researched. Measure creatinekinase is important if pain or walking disability after viral episode. Early intervention avoids complications.

Acute Radiation Oedema of Perithyroid Tissues — A Serious Complication of the Treatment of Thyroid Disorders with High Doses of Radioiodine

1965 ◽  
Vol 05 (01) ◽  
pp. 68-75 ◽  
Author(s):  
R. Höschl ◽  
K. Šilink ◽  
J. Kubal ◽  
J. Nemec
Keyword(s):  
Thyroid Cancer ◽  
Preventive Measures ◽  
Upper Respiratory Tract ◽  
Radioiodine Treatment ◽  
Dose Administration ◽  
Life Saving ◽  
Life Threatening ◽  
Upper Respiratory ◽  
High Doses ◽  
Tissue Oedema

Summary and conclusions17 cases with soft tissue oedema developing early after radioiodine treatment of thyroid cancer are described. The typical clinical picture of this complication of radioiodine treatment consists of a sudden rapidly increasing swelling of soft perithyroid tissues during the first 48 hours after the dose administration. The swelling is accompanied by serious breathing distress, most probably as a result of submucosal tissue oedema in the upper respiratory tract. This syndrom is believed to be a life-threatening clinical entity complicating the early course of radioiodine treatment of thyroid cancer, and differing from radiation thyroiditis. In the literature two similar cases were found. The incidence of perithyroid oedema in our patients was 13.2%. Perithyroid oedema occurred usually after large single doses but was not predictable. The possible preventive measures and therapeutic effect of corticoids as life-saving treatment are pointed out.

Primary Tuberculosis of pharynx-diagnostic difficulties, complications and treatment

2015 ◽  
Vol 1 (1) ◽  
pp. 62-65
Author(s):  
Tika R. Adhikari ◽  
Rahmat Omar
Keyword(s):  
Respiratory Tract ◽  
Airway Compromise ◽  
Upper Respiratory Tract ◽  
Diagnostic Challenge ◽  
Primary Tuberculosis ◽  
Delay In Diagnosis ◽  
Emergency Tracheostomy ◽  
Diagnostic Difficulties ◽  
Life Threatening ◽  
Upper Respiratory

Primary tuberculosis of the upper respiratory tract is extremely rare and poses a diagnostic challenge. Due to delay in diagnosis the disease may progress to life threatening airway compromise. Here we report a case of chronic granulomatous infection of the upper respiratory tract involving the oropharynx. Initial biopsy revealed acute on chronic inflammation with no epitheloid granuloma and no acid fast bacilli was found on Ziehl-Nielsen staining of the biopsy. As a result of delay in diagnosis the disease progressed to involve the soft palate, valopharyngeal isthmus, and supraglottis compromising the airway and needed emergency tracheostomy. Where there is strong clinical suspicion repeat biopsy should be performed. The life threatening complication of pharyngeal tuberculosis such as stenosis and adhesion leading to airway compromise can occur during the course of treatment and should be closely monitored . It can be managed effectively with radiofrequency uvulopalatoplasty as demonstrated in the case report.

scholarly journals Injuries and illnesses related to dinghy-sailing on hydrofoiling boats

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Francesco Feletti ◽  
Eric Brymer ◽  
Matteo Bonato ◽  
Andrea Aliverti
Keyword(s):  
High Speed ◽  
Respiratory Tract Infections ◽  
Injury Rate ◽  
High Energy ◽  
Lower Limbs ◽  
Upper Respiratory Tract ◽  
Anatomical Distribution ◽  
Acute Injuries ◽  
Upper Respiratory ◽  
Tract Infections

Abstract Background Hydrofoil technology has changed sailing, significantly increasing its speed and resulting in spectacularity and mass media interest. Although high speed can expose participants to a risk of high-energy trauma, there are no scientific studies related to trauma in dinghies that exploit this technology. Therefore, this study aims primarily to measure the injury rate, and identify the kind and anatomical distribution of most common injuries and secondarily identify the traumatic dynamics most often involved and the main risk factors. Methods This descriptive epidemiology study examined data relative to injuries and illnesses suffered by 77 sailors (91% males) from 13 nationalities during three international, gathered through a specifically designed questionnaire. Results The prevalence of illnesses and overuse injuries during the regatta week were 6.5% and 18.2%, respectively, while the incidence of acute injuries was 16/1000 sailor-hours. Upper limbs, lower limbs and lumbar spine were involved in 34.6%, 26.9% and 15.4% of cases of musculoskeletal injuries, respectively. None of the acute injuries reached the maximal score of severity, while the higher score value was 63/100. Most of the reported illnesses (80%; n = 4) were upper respiratory tract infections with a prevalence in the week of the regatta of 5.2% and an incidence of 0.51/1000 sailor-hours. Environmental factors played a role in 77% of the incidents resulting in acute injuries. Conclusions This study provides valuable information for regatta organizers, boat builders, athletes, coaches, and doctors. In addition, it fosters the importance of ergonomics of boats, adequate clothing and specific physical training for injuries and illnesses prevention.

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