scholarly journals Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors

2022 ◽  
Author(s):  
Alessandro Prete ◽  
Anuradhaa Subramanian ◽  
Irina Bancos ◽  
Vasileios Chortis ◽  
Stylianos Tsagarakis ◽  
...  
Keyword(s):  
Disease Burden ◽  
Cardiometabolic Disease ◽  
Adrenal Tumors ◽  
Steroid Excretion

Increasing Cardiometabolic Disease Burden Leads To Worse Outcomes In Patients with HFpEF: A TOPCAT Analysis

2020 ◽  
Vol 26 (10) ◽  
pp. S120
Author(s):  
Margaret J. Stevenson ◽  
Usman Tahir ◽  
Kevin Kennedy ◽  
Shweta R. Motiwala ◽  
Jeremy M. Robbins ◽  
...  
Keyword(s):  
Disease Burden ◽  
Cardiometabolic Disease

scholarly journals A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

2021 ◽  
Author(s):  
Lucas J Osborn ◽  
Karlee Schultz ◽  
William Massey ◽  
Beckey DeLucia ◽  
Ibrahim Choucair ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Disease Burden ◽  
Fruits And Vegetables ◽  
Molecular Mechanisms ◽  
Treatment Strategies ◽  
Cardiometabolic Disease ◽  
Catabolic Pathway ◽  
Human Gut ◽  
Dietary Polyphenols ◽  
Continuous Delivery

The molecular mechanisms by which dietary fruits and vegetables confer cardiometabolic benefits remain poorly understood. Historically, these beneficial properties have been attributed to the antioxidant activity of flavonoids. Here, we reveal that the host metabolic benefits associated with flavonoid consumption actually hinge on gut microbial metabolism. We show that a single gut microbial flavonoid catabolite is sufficient to reduce diet-induced cardiometabolic disease burden in mice. Dietary supplementation with elderberry extract attenuated obesity and continuous delivery of the catabolite 4-hydroxphenylacetic acid was sufficient to reverse hepatic steatosis. Analysis of human gut metagenomes revealed that under one percent contains a flavonol catabolic pathway, underscoring the rarity of this process. Our study will impact the design of dietary and probiotic interventions to complement traditional cardiometabolic treatment strategies.

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

2021 ◽  
Author(s):  
Alessandro Prete ◽  
Anuradhaa Subramanian ◽  
Irina Bancos ◽  
Vasileios Chortis ◽  
Stylianos Tsagarakis ◽  
...  
Keyword(s):  
Disease Burden ◽  
Case Control Study ◽  
Case Control ◽  
Cardiometabolic Disease ◽  
Adrenocortical Tumours ◽  
Control Study ◽  
Urine Steroid

Bronchiectasis-Associated Hospitalizations in Germany, 2005 – 2011: A Population-Based Study of Disease Burden and Trends

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
FC Ringshausen ◽  
A de Roux ◽  
MW Pletz ◽  
N Hämäläinen ◽  
T Welte ◽  
...  
Keyword(s):  
Disease Burden ◽  
Population Based ◽  
Population Based Study

ON THE VALUE OF SOME PARAMETERS OF ADRENOCORTICAL GLUCOCORTICOID FUNCTION

1963 ◽  
Vol 44 (4) ◽  
pp. 499-504 ◽  
Author(s):  
M. Van Der Straeten ◽  
A. Vermeulen ◽  
N. Orie ◽  
P. Regniers
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Isotope Dilution ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Steroid Excretion ◽  
Colorimetric Methods

ABSTRACT The authors studied the correlation between cortisol production, as measured by an isotope dilution method, and the urinary excretion of total and free Porter-Silber chromogens, as well as of 17-ketogenic steroids. Although a significant correlation exists between total Porter-Silber chromogens, 17-ketogenic steroid excretion and cortisol production, discrepancies are occasionally observed. Hence, different colorimetric methods should be used to assess the glucocorticoid activity of the adrenal cortex.

ADRENOCORTICAL FUNCTION IN PATIENTS WITH ACUTE SEVERE BRAIN AND PITUITARY LESION

1962 ◽  
Vol 40 (2) ◽  
pp. 254-262 ◽  
Author(s):  
H. H. Bassøe ◽  
R. Emberland ◽  
E. Glück ◽  
K. F. Støa
Keyword(s):  
Pituitary Gland ◽  
Adrenal Cortex ◽  
Artificial Ventilation ◽  
Practical Significance ◽  
Adrenocortical Function ◽  
The Third ◽  
Low Levels ◽  
Pituitary Lesion ◽  
Steroid Excretion ◽  
The Brain

ABSTRACT The steroid excretion and the plasma corticosteroids were investigated in three patients with necrosis of the brain and of the pituitary gland. The patients were kept alive by artificial ventilation. In two of the patients the neutral 17-ketosteroids and the 17-hydrocorticosteroids fell to extremely low levels. At the same time, the number of eosinophil cells showed a tendency to increase. Corticotrophin administered intravenously twice to the third patient had a stimulating effect on the adrenal cortex. The theoretical and practical significance of these findings is discussed.

FLUCTUABILITY OF STEROID EXCRETION

1957 ◽  
Vol 26 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Herman Zondek ◽  
Gerda W. Zondek ◽  
Hannah E. Leszynsky
Keyword(s):  
Steroid Excretion
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