scholarly journals Nonendoscopic Detection of Barrett Esophagus and Esophageal Adenocarcinoma: Recent Advances and Implications

2021 ◽  
Author(s):  
Prasad G. Iyer ◽  
David A. Katzka
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Barrett Esophagus ◽  
Recent Advances

scholarly journals Germline Mutations in MSR1, ASCC1, and CTHRC1 in Patients With Barrett Esophagus and Esophageal Adenocarcinoma

JAMA ◽  
2011 ◽  
Vol 306 (4) ◽  
pp. 410 ◽  
Author(s):  
Mohammed Orloff ◽  
Charissa Peterson ◽  
Xin He ◽  
Shireen Ganapathi ◽  
Brandie Heald ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Germline Mutations ◽  
Barrett Esophagus

Barrett Esophagus Length, Nodularity, and Low-grade Dysplasia are Predictive of Progression to Esophageal Adenocarcinoma

2019 ◽  
Vol 53 (5) ◽  
pp. 361-365 ◽  
Author(s):  
Dipesh Solanky ◽  
Rajesh Krishnamoorthi ◽  
Nicholas Crews ◽  
Michele Johnson ◽  
Kenneth Wang ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Barrett Esophagus ◽  
Low Grade ◽  
Low Grade Dysplasia

Long-term follow-up of patients with Barrett esophagus: Progression to high-grade dysplasia and esophageal adenocarcinoma according to histology at presentation.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 20-20 ◽  
Author(s):  
Allon Kahn ◽  
Vishnu Kommineni ◽  
Jonathan Callaway ◽  
Rahul Pannala ◽  
David Fleischer ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Large Cohort ◽  
High Grade Dysplasia ◽  
Continuous Treatment ◽  
Barrett Esophagus ◽  
Low Grade ◽  
High Grade ◽  
Upper Endoscopy ◽  
Early Stage Disease

20 Background: Esophageal adenocarcinoma (EAC) incidence is rising and prognosis is uniformly poor, even with early stage disease. Barrett esophagus (BE) serves as a premalignant marker for EAC, with an estimated progression of 0.5% per year. Low-grade (LGD) and high-grade dysplasia (HGD) confer a higher risk of progression, providing an opportunity for intervention and surveillance. Aims: To evaluate a large cohort of patients undergoing endoscopic evaluation of BE and thereby better understand the natural history of BE and dysplasia. Methods: A retrospective review of endoscopic databases was conducted for all patients with the diagnosis of BE undergoing upper endoscopy at a tertiary academic medical center from 1991-2010. All endoscopy and accompanying pathology reports were reviewed. Only those patients with 2 biopsies documenting specialized intestinal metaplasia were analyzed. Results: 848 patients underwent upper endoscopy for evaluation of BE. Of these, 674 patients met inclusion criteria, at a mean follow up of 66.6 months. Table 1 depicts the distribution of patients according to their histology at presentation. 22 (3.2%) patients presented with established EAC, while EAC developed in 51 (7.6%). Of patients with HGD, LGD, or no dysplasia (ND) at presentation, EAC ultimately developed in 30.6%, 6.6%, and 2.7%, respectively. EAC developed in 4 patients despite RFA treatment for ND (2) or LGD (2). HGD developed in 6 such patients after treatment for ND (3) and LGD (3). Only 1 patient in each RFA-treated cohort required esophagectomy, while the others cleared dysplasia or EAC with continuous treatment. Conclusions: In this large cohort of patients with Barrett’s esophagus, higher grade of dysplasia at first endoscopy was associated with development of EAC. Continuous surveillance during and after endoscopic treatment is necessary and often results in clearance of dysplasia and EAC. [Table: see text]

T1927 Risk of Esophageal Adenocarcinoma and Mortality in Patients with Barrett Esophagus: A Systematic Review and Meta-Analysis

2009 ◽  
Vol 136 (5) ◽  
pp. A-602
Author(s):  
Marjolein Sikkema ◽  
P.J. de Jonge ◽  
Ewout W Steyerberg ◽  
Ernst J. Kuipers
Keyword(s):  
Systematic Review ◽  
Esophageal Adenocarcinoma ◽  
Meta Analysis ◽  
Barrett Esophagus

scholarly journals Esophageal adenocarcinoma arising in Barrett esophagus

2009 ◽  
Vol 275 (2) ◽  
pp. 170-177 ◽  
Author(s):  
Hui Ying Zhang ◽  
Stuart Jon Spechler ◽  
Rhonda F. Souza
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Barrett Esophagus
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