scholarly journals Tenofovir Alafenamide for HIV Preexposure Prophylaxis: What Can We DISCOVER About Its True Value?

2020 ◽  
Vol 172 (4) ◽  
pp. 281 ◽  
Author(s):  
Douglas S. Krakower ◽  
Demetre C. Daskalakis ◽  
Judith Feinberg ◽  
Julia L. Marcus
Keyword(s):  
True Value ◽  
Preexposure Prophylaxis ◽  
Tenofovir Alafenamide

scholarly journals Tenofovir Alafenamide for HIV Preexposure Prophylaxis

2020 ◽  
Vol 173 (1) ◽  
pp. 78
Author(s):  
Douglas S. Krakower ◽  
Demetre C. Daskalakis ◽  
Judith Feinberg ◽  
Julia L. Marcus
Keyword(s):  
Preexposure Prophylaxis ◽  
Tenofovir Alafenamide

Comparative Pricing of Branded Tenofovir Alafenamide–Emtricitabine Relative to Generic Tenofovir Disoproxil Fumarate–Emtricitabine for HIV Preexposure Prophylaxis

2020 ◽  
Vol 173 (6) ◽  
pp. 507-508
Author(s):  
Rochelle P. Walensky ◽  
Tim Horn ◽  
Nicole C. McCann ◽  
Kenneth A. Freedberg ◽  
A. David Paltiel
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Preexposure Prophylaxis ◽  
Tenofovir Alafenamide

scholarly journals A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs

2021 ◽  
Author(s):  
Doris Zane ◽  
Shane Roller ◽  
Josephine Shelton ◽  
Roshni Singh ◽  
Rachna Jain ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
People Living With Hiv ◽  
Subcutaneous Infusion ◽  
Helpful Tool ◽  
Antiretroviral Therapies ◽  
Preexposure Prophylaxis ◽  
Immunodeficiency Virus ◽  
Tenofovir Alafenamide ◽  
Living With Hiv

Human immunodeficiency virus (HIV) infection continues to be a serious global human health issue, with ∼38 million people living with HIV worldwide at the end of 2019. HIV preexposure prophylaxis (PrEP) has introduced the use of antiretroviral therapies as another helpful tool for slowing the spread of HIV worldwide.

scholarly journals Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide for Human Immunodeficiency Virus Preexposure Prophylaxis at a Boston Community Health Center

2021 ◽  
Vol 8 (8) ◽  
Author(s):  
Julia L Marcus ◽  
Kenneth Levine ◽  
Whitney C Sewell ◽  
Patricia Solleveld ◽  
Kenneth H Mayer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Cardiovascular Risk ◽  
Creatinine Clearance ◽  
Cardiovascular Risk Factors ◽  
Tenofovir Disoproxil Fumarate ◽  
Community Health Center ◽  
Preexposure Prophylaxis ◽  
Immunodeficiency Virus ◽  
Tenofovir Alafenamide

Abstract Background Efforts to end the human immunodeficiency virus (HIV) epidemic may be threatened if limited preexposure prophylaxis (PrEP) resources are funneled from tenofovir disoproxil fumarate with emtricitabine (TDF/FTC) to tenofovir alafenamide with emtricitabine (TAF/FTC) without proportional clinical benefits. Methods The study population was patients at a Boston community health center who were assigned male sex at birth, aged ≥18 years, and prescribed TDF/FTC for PrEP in the 12 months before TAF/FTC approval (October 2019). We determined the frequency of switching to TAF/FTC in the 12 months after approval, including clinically indicated switching (ie, creatinine clearance <60 mL/minute or reduced bone density), potentially unnecessary switching (ie, no indications for switching and no cardiovascular risk factors), and potentially harmful switching (ie, no indications for switching and either obesity or dyslipidemia). Results Of 2892 TDF/FTC users, mean age was 38 years, 96.0% were cisgender men, and 78.9% were white. A total of 343 (11.9%) switched to TAF/FTC. Based on documented renal, bone, and cardiovascular risk factors, we identified 24 (7.0%) with clinically indicated switching, 271 (79.0%) with potentially unnecessary switching, and 48 (14.0%) with potentially harmful switching. When indications for switching additionally included hypertension, diabetes, and creatinine clearance 60–70 mL/minute, 27.1% of switching was clinically indicated. Conclusions Few who switched to TAF/FTC had documented indications for switching, although some appear to have been switched in anticipation of indications developing. As generic TDF/FTC is further discounted, provider education and patient decision aids are needed to facilitate selection of PrEP medications that is both clinically sound and cost-effective.

scholarly journals Comparative Pricing of Branded Tenofovir Alafenamide–Emtricitabine Relative to Generic Tenofovir Disoproxil Fumarate–Emtricitabine for HIV Preexposure Prophylaxis

2020 ◽  
Vol 172 (9) ◽  
pp. 583-590 ◽  
Author(s):  
Rochelle P. Walensky ◽  
Tim Horn ◽  
Nicole C. McCann ◽  
Kenneth A. Freedberg ◽  
A. David Paltiel
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Preexposure Prophylaxis ◽  
Tenofovir Alafenamide

Tenofovir Alafenamide for HIV Preexposure Prophylaxis

2020 ◽  
Vol 173 (1) ◽  
pp. 77-78 ◽  
Author(s):  
Diana Brainard ◽  
Scott McCallister
Keyword(s):  
Preexposure Prophylaxis ◽  
Tenofovir Alafenamide

MOTIF YANG BERPENGARUH PADA PROSES KEJIWAAN TOKOH SAM DALAM NOVEL SEBENING SYAHADAT KARYA DIVA SR

2020 ◽  
Vol 8 (2) ◽  
pp. 10
Author(s):  
Dandy Ashghor Dawudi ◽  
Kamidjan Kamidjan ◽  
Agus Sulton
Keyword(s):  
Research Method ◽  
Descriptive Analysis ◽  
Research Process ◽  
Cultural Factors ◽  
Qualitative Approach ◽  
Literature Study ◽  
Love Story ◽  
True Value ◽  
Analysis Technique ◽  
Qualitative Descriptive

This research takes the object of Sebening Syahadat by Diva SR, this work is a novel that tells the story of the journey ofa teenager named Sam who is in the process ofsearching for identity. The journey is filled with interesting twits and turns embelissed with a love story that is very suitable if consumed by the younger generation who are learning to find identit. This study aims to reveal the value motives that led Sam’s character in finding his identity, which expected to be a material for reflection for readers, especially young people who are in the process of discovering his identity, the scope of the problem in this study is to reveal the value motives that affect the character’s psyche. Sam is told to have a rascal character.The research method used in this study took a descriptive qualitative approach, data colletion used was a literature study technique with stages of reading, note taking, coding for futher analysis. The analysis technique used is qualitative descriptive analysis technique.The result of the research in this research process indicate that the mental process of Sam’s character influenced by several factors, including: a. Motives in cultural factors (Situasional Factors), b. The motive for love begins with admiration for the attitude of someone who is full of noble values of character, c. The motive of curiosity and fulfillment of his needs for true value.

The True Value of LASERs

1995 ◽  
Vol 5 (6) ◽  
pp. 8.2-9
Author(s):  
Bruce Fox
Keyword(s):  
True Value

842-P: Damage Control (Group) for Youth with T1D: Capturing the True Value of NICH

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 842-P
Author(s):  
DAVID V. WAGNER ◽  
CELESTE JENISCH ◽  
NATALIE C. KOSKELA-STAPLES ◽  
INES GUTTMANN-BAUMAN ◽  
CHRISTOPHER E. LARSEN ◽  
...  
Keyword(s):  
Damage Control ◽  
Control Group ◽  
True Value
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