scholarly journals Network Meta-analysis for Clinical Practice Guidelines: A Case Study on First-Line Medical Therapies for Primary Open-Angle Glaucoma

2016 ◽  
Vol 164 (10) ◽  
pp. 674 ◽  
Author(s):  
Benjamin Rouse ◽  
Andrea Cipriani ◽  
Qiyuan Shi ◽  
Anne L. Coleman ◽  
Kay Dickersin ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Open Angle ◽  
First Line ◽  
Medical Therapies

Evaluation of primary open-angle glaucoma clinical practice guidelines

2015 ◽  
Vol 50 (3) ◽  
pp. 192-196 ◽  
Author(s):  
Annie M. Wu ◽  
Connie M. Wu ◽  
Benjamin K. Young ◽  
Dominic J. Wu ◽  
Allison Chen ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

scholarly journals Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Xiang ◽  
Yi Dong ◽  
Xuan Li ◽  
Xin Tang
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Female Group ◽  
Enos Gene ◽  
Open Angle ◽  
Oxide Synthase ◽  
Stratified Analysis ◽  
Endothelial Nitric Oxide

Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG).Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model ifI2<50%in the test for heterogeneity; otherwise the random-effects model was used.Results. Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group.Conclusions. TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group.

Australian and New Zealand Clinical Practice Guidelines for the Treatment of Panic Disorder and Agoraphobia

2003 ◽  
Vol 37 (6) ◽  
pp. 641-656 ◽  
Author(s):  
Keyword(s):  
Clinical Practice ◽  
New Zealand ◽  
Panic Disorder ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Meta Analysis ◽  
Prognostic Indicator ◽  
Time Frame ◽  
Behaviour Therapy ◽  
Cognitive Behaviour

Background: The Royal Australian and New Zealand College of Psychiatrists is coordinating the development of clinical practice guidelines (CPGs) in psychiatry, funded under the National Mental Health Strategy (Australia) and the New Zealand Health Funding Authority. Method: For these guidelines, the CPG team reviewed the treatment outcome literature, consulted with practitioners and patients and conducted a meta-analysis of recent outcome research. Treatment recommendations: Education for the patient and significant others covering: (i) the nature and course of panic disorder and agoraphobia; (ii) an explanation of the psychopathology of anxiety, panic and agoraphobia; (iii) rationale for the treatment, likelihood of a positive response, and expected time frame. Cognitive behaviour therapy (CBT) is more effective and more cost-effective than medication. Tricyclic antidepressants (TCAs) and serotonin selective reuptake inhibitors are equal in efficacy and both are to be preferred to benzodiazepines. Treatment choice depends on the skill of the clinician and the patient's circumstances. Drug treatment should be complemented by behaviour therapy. If the response to an adequate trial of a first-line treatment is poor, another evidence-based treatment should be used. A second opinion can be useful. The presence of severe agoraphobia is a negative prognostic indicator, whereas comorbid depression, if properly treated, has no consistent effect on outcome.

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