Graves Disease With Thyroid-Stimulating Hormone Receptor–Blocking Autoantibodies During Pregnancy

2020 ◽  
Vol 172 (11) ◽  
pp. 767-769 ◽  
Author(s):  
Brigitte Decallonne ◽  
Pieter-Jan Martens ◽  
Annick Van den Bruel ◽  
Christine Vanhole ◽  
George J. Kahaly
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Receptor Blocking ◽  
Stimulating Hormone

scholarly journals Non-immune thyrotoxicosis caused by thyroid-stimulating hormone receptor activating gene mutation (the first description in Russia)

2009 ◽  
Vol 55 (2) ◽  
pp. 48-50
Author(s):  
V A Peterkova ◽  
O V Vasyukova ◽  
A N Tyul'pakov
Keyword(s):  
Pregnant Women ◽  
Gene Mutation ◽  
Clinical Picture ◽  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Maternal Antibodies ◽  
Graves Disease ◽  
Gene Encoding ◽  
Activating Mutations ◽  
Stimulating Hormone

Thyrotoxicosis of newborns, observed in less than 1% of pregnant women with Graves disease, is due to transplacental transfer of stimulating antibodies to the thyroid stimulating hormone receptor (rTSH). The clinical picture manifests itself in the first days of a child’s life, is transient in nature and, as a rule, ends with a full recovery as the maternal antibodies to rTSH disappear from the bloodstream of the newborn. However, in addition to the "classic" autoimmune thyrotoxicosis, cases of congenital and familial non-autoimmune thyrotoxicosis, which are caused by inherited activating mutations of the gene encoding rTSH - TSHR, have been described. This article presents its own observation.

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