scholarly journals Development and optimization of in-situ forming microparticles for long term controlled delivery of deslorelin acetate

2018 ◽  
Keyword(s):  
Controlled Delivery ◽  
In Situ Forming

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Impact of octreotide counterion nature on the long-term stability and release kinetics from an in situ forming depot technology

2021 ◽  
Vol 336 ◽  
pp. 457-468
Author(s):  
Charlotte Molinier ◽  
Marina Picot-Groz ◽  
Océane Malval ◽  
Sophie Le Lamer-Déchamps ◽  
Joël Richard ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Term Stability ◽  
Long Term Stability ◽  
In Situ Forming ◽  
Counterion Nature

First report on the efficacy of l-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs

2005 ◽  
Vol 108 (2-3) ◽  
pp. 433-441 ◽  
Author(s):  
François Plourde ◽  
Aude Motulsky ◽  
Anne-Claude Couffin-Hoarau ◽  
Didier Hoarau ◽  
Huy Ong ◽  
...  
Keyword(s):  
First Report ◽  
Parenteral Delivery ◽  
In Situ Forming ◽  
In Situ Forming Implants

scholarly journals In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules

ACS Omega ◽  
2020 ◽  
Vol 5 (28) ◽  
pp. 17531-17542
Author(s):  
Kingshuk Dutta ◽  
Ritam Das ◽  
Jing Ling ◽  
Rafael Mayoral Monibas ◽  
Ester Carballo-Jane ◽  
...  
Keyword(s):  
Controlled Delivery ◽  
In Situ Forming ◽  
Thermoresponsive Hydrogels

scholarly journals Pharmacokinetic Studies of an In Situ Forming Gel System for Controlled Delivery of Enrofloxacin In Pigs

2018 ◽  
Vol 5 (1) ◽  
pp. 1-5
Author(s):  
Zugong Yu ◽  
Huimin Li ◽  
Fanxi Zhang Zhang ◽  
Zhenrui Zhang ◽  
Jing Tian ◽  
...  
Keyword(s):  
Controlled Delivery ◽  
Pharmacokinetic Studies ◽  
In Situ Forming ◽  
In Situ Forming Gel ◽  
Gel System
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