scholarly journals Analysis of Electropherogram Profile of Crude Cartilage Oligomeric Matrix Protein for Rheumatoid Arthritis Diagnosis

2017 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Rheumatoid Arthritis Diagnosis

Can Tocilizumab Decrease Cartilage Oligomeric Matrix Protein Levels and Disease Activity in Patients with Long-Standing Rheumatoid Arthritis?

2015 ◽  
Vol 11 (999) ◽  
pp. 1-1
Author(s):  
Maurizio Benucci ◽  
Francesca Meacci ◽  
Mariangela Manfredi ◽  
Francesca Gobbi ◽  
Maria Infantino ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Protein Levels

scholarly journals Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression

2016 ◽  
Vol 9 (1) ◽  
pp. 15-23
Author(s):  
SAID AL-DALAEN ◽  
AIMAN AL-QTAITAT ◽  
MOHAMMAD AL-RAWASHDEH ◽  
JIHAD ALZYOUD ◽  
AIMAN AL-MAATHADI
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Disease Progression ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
And Cartilage

scholarly journals CORRELATION STUDY OF SERUM CALCIUM LEVELS AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS IN RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA

2017 ◽  
Vol 10 (11) ◽  
pp. 401
Author(s):  
Nyi Mekar Saptarini ◽  
Marlia Singgih Wibowo ◽  
Tutus Gusdinar
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Calcium ◽  
Calcium Level ◽  
Cartilage Oligomeric Matrix Protein ◽  
Serum Calcium Level ◽  
Matrix Protein ◽  
Correlation Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rheumatology Clinic ◽  
Protein Levels

  Objective: This study was designed is to determine the correlation between serum calcium level and serum cartilage oligomeric matrix protein (COMP) level in Indonesian patients with rheumatoid arthritis (RA).Subjects and Methods: The subjects are patients who visit the rheumatology clinic at a government hospital in Bandung, Indonesia. Serum calcium level was determined by a complexometric method, and the serum COMP level was determined by enzyme-linked immunosorbent assay. Statistical analysis was performed with R software.Results: The serum calcium level was 82.24±44.82 mg/mL in RA patients and 99.04±60.56 mg/mL in normal controls. The serum COMP level was 843.80±35.79 ng/ml in RA patients and 830.00±48.92 ng/ml in normal controls.Conclusion: There is no correlation between serum calcium level and serum COMP levels in RA patients (p=0.967 and rho=0.006).

scholarly journals Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis

2009 ◽  
Vol 4 ◽  
pp. BMI.S645 ◽  
Author(s):  
Susan Tseng ◽  
A. Hari Reddi ◽  
Paul E. Di Cesare
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Clinical Manifestations ◽  
Biological Marker ◽  
Prognostic Indicator ◽  
Cartilage Degradation ◽  
Recent Onset ◽  
Effect Of Treatment ◽  
Early Phases

Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheumatoid arthritis and osteoarthritis, it becomes important to identify prognostic factors that can predict the evolution of arthritis. This is especially critical in the early phases of disease so that these treatments can be started as soon as possible to slow down progression of the disease. A valuable approach to monitor arthritis would be by measuring biological markers of cartilage degradation and repair to reflect variations in joint remodeling. One such potential biological marker of arthritis is cartilage oligomeric matrix protein (COMP). In various studies, COMP has shown promise as a diagnostic and prognostic indicator and as a marker of the disease severity and the effect of treatment. This review highlights the progress in the utilization of COMP as a biomarker of arthritis.

scholarly journals Relationship between cartilage oligomeric matrix protein (COMP) and rheumatoid arthritis severity

10.19082/5940 ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 5940-5947 ◽  
Author(s):  
Massoud Saghafi ◽  
Mandana Khodashahi ◽  
Nayyereh Saadati ◽  
Azita Azarian ◽  
Zahra Rezaieyazdi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Arthritis Severity ◽  
Rheumatoid Arthritis Severity

scholarly journals Cartilage Oligomeric Matrix Protein Induced Arthritis—A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse

2021 ◽  
Vol 12 ◽  
Author(s):  
Yunjuan Zhao ◽  
Vilma Urbonaviciute ◽  
Bingze Xu ◽  
Weiwei Cai ◽  
Zeynep Sener ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mhc Class Ii ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Peptide Binding ◽  
Cell Epitope ◽  
Class Ii ◽  
Human Cartilage ◽  
New Model ◽  
Induce Arthritis

The most commonly used strains in experimental research, including genetically modified strains, are C57BL/6 mice. However, so far, no reliable model for rheumatoid arthritis is available, mainly due to the restriction by the MHC class II haplotype H-2b. Collagen-induced arthritis (CIA) is the most widely used animal model of rheumatoid arthritis, but C57BL/6 strain is resistant to CIA because there is no collagen II peptide associated with H-2b. To establish a rheumatoid arthritis model in C57BL/6 mice, we immunized C57BL/6NJ (B6N) mice with human cartilage oligomeric matrix protein (COMP), which induced severe arthritis with high incidence, accompanied by a strong auto-antibody response. Native COMP was required, as denatured COMP lost its ability to induce arthritis in B6N mice. An immunodominant COMP peptide was identified as the key T cell epitope, with a perfect fit into the Ab class II peptide binding pocket. A critical amino acid in this peptide was found to be phenylalanine at position 95. Recombinant COMP mutated at position 95 (COMP_F95S) lost its ability to induce arthritis or a strong immune response in the B6N mice. In conclusion, A new model for RA has been established using C57BL/6 mice through immunization with COMP, which is dependent on a COMP specific peptide binding Ab, thus in similarity with CIA in Aq expressing strains.

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