scholarly journals Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.


Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2179
Author(s):  
Wamidh H. Talib ◽  
Asma Ismail Mahmod ◽  
Sara Feras. Abuarab ◽  
Eliza Hasen ◽  
Amer A. Munaim ◽  
...  

Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.


2012 ◽  
Vol 3 (1) ◽  
pp. 315-316
Author(s):  
Dr. Sanay Prajapati ◽  
◽  
Dr. Divyesh Patel ◽  
Dr. Jay Panchal ◽  
Dr. Viplav Gndhi ◽  
...  

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