scholarly journals Inhibition of Mitochondrial Respiratory Chain Activity by O, O-Dimethyl- and 4-O- Methyl- Alpinumisoflavones

2017 ◽  
Keyword(s):  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory Chain Activity ◽  
Respiratory Chain Activity ◽  
Mitochondrial Respiratory

Mitochondrial respiratory chain activity in an animal model of mania induced by ouabain

2011 ◽  
Vol 23 (3) ◽  
pp. 106-111 ◽  
Author(s):  
Tiago P. Freitas ◽  
Gislaine T. Rezin ◽  
Daiane B. Fraga ◽  
Morgana Moretti ◽  
Julia S. Vieira ◽  
...  
Keyword(s):  
Animal Model ◽  
Prefrontal Cortex ◽  
Respiratory Chain ◽  
Rebound Effect ◽  
Mitochondrial Respiratory Chain ◽  
Face Validity ◽  
Mitochondrial Respiratory Chain Activity ◽  
Respiratory Chain Activity ◽  
The Brain ◽  
Mitochondrial Respiratory

Objectives: Bipolar disorder (BD) is a mental illness associated with higher rates of suicide. The present study aims to investigate the brain mitochondrial respiratory chain activity in an animal model of mania induced by ouabain.Methods: Adult male Wistar rats received a single intracerebroventricular administration of ouabain (10−3 and 10−2 M) or vehicle. Locomotor activity was measured using the open field test. Mitochondrial respiratory chain activity was measured in the brain of rats 1 h and 7 days after ouabain administration.Results: Our results showed that spontaneous locomotion was increased 1 h and 7 days after ouabain administration. Complexes I, III and IV activities were increased in the prefrontal cortex, hippocampus and striatum immediately after the administration of ouabain, at the concentration of 10−3 and 10−2 M. Moreover, complex II activity was increased only in the prefrontal cortex at the concentration of 10−2 M. On the other hand, no significant alterations were observed in complex I activity 7 days after ouabain administration. However, an increase in complexes II, III and IV activities was observed only in the prefrontal cortex at the concentration of 10−2 M.Conclusion: Our findings suggest an increase in the activities of mitochondrial respiratory chain in this model of mania. A possible explanation is that these findings occur as a rebound effect trying to compensate for a decrease of ATP deprivation in BD. The present findings suggest that this model may present good face validity and a limitation in construct validity.

Melatonin improves mitochondrial respiratory chain activity and liver morphology in ob/ob mice

2011 ◽  
Vol 51 (1) ◽  
pp. 113-123 ◽  
Author(s):  
Pablo Solís-Muñoz ◽  
José A. Solís-Herruzo ◽  
Daniel Fernández-Moreira ◽  
Erica Gómez-Izquierdo ◽  
Inés García-Consuegra ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory Chain Activity ◽  
Liver Morphology ◽  
Respiratory Chain Activity ◽  
Mitochondrial Respiratory
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