scholarly journals Infantile colic treatment: new prospects

2013 ◽  
Author(s):  
Francesco Savino ◽  
Angela De Marco ◽  
Simone Ceratto
Keyword(s):  
Milk Proteins ◽  
Infantile Colic ◽  
Herbal Supplements ◽  
Over The Counter ◽  
Pharmacological Agents ◽  
Benign Condition ◽  
Behavioral Therapies ◽  
New Treatments ◽  
Pediatric Consultation ◽  
Evidence Based Guidelines

Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue and there is no consensus concerning management and treatment. In literature are growing evidences about the effectiveness of dietary, pharmacological, complementary and behavioral therapies as options for the management of infantile colic. Dietary approach is based on the avoidance of cow’s milk proteins in breast-feeding mothers and bottle-fed infants. Currently pharmacological agents over the counter or by prescription are not recommended because of reported side effects. There is limited evidence supporting the use of complementary and alternative treatments (herbal supplements, manipulative approach and acupuncture) or behavioral modification interventions. Recent studies have partially clarified the pathogenesis of this disturb and so new treatments, such as probiotics, have been proposed. Further investigations are needed in order to provide evidence-based guidelines.

scholarly journals Infantile colic treatment: new prospects

2013 ◽  
Author(s):  
Francesco Savino ◽  
Angela De Marco ◽  
Simone Ceratto
Keyword(s):  
Milk Proteins ◽  
Infantile Colic ◽  
Herbal Supplements ◽  
Over The Counter ◽  
Pharmacological Agents ◽  
Benign Condition ◽  
Behavioral Therapies ◽  
New Treatments ◽  
Pediatric Consultation ◽  
Evidence Based Guidelines

Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue and there is no consensus concerning management and treatment. In literature are growing evidences about the effectiveness of dietary, pharmacological, complementary and behavioral therapies as options for the management of infantile colic. Dietary approach is based on the avoidance of cow’s milk proteins in breast-feeding mothers and bottle-fed infants. Currently pharmacological agents over the counter or by prescription are not recommended because of reported side effects. There is limited evidence supporting the use of complementary and alternative treatments (herbal supplements, manipulative approach and acupuncture) or behavioral modification interventions. Recent studies have partially clarified the pathogenesis of this disturb and so new treatments, such as probiotics, have been proposed. Further investigations are needed in order to provide evidence-based guidelines.

Current and Emerging Treatments for Methamphetamine-use Disorder

2021 ◽  
Vol 19 ◽  
Author(s):  
Anna Moszczynska
Keyword(s):  
Clinical Trials ◽  
Causes Of Death ◽  
Methamphetamine Use ◽  
Current Prevalence ◽  
The Us ◽  
Emerging Treatments ◽  
History Of ◽  
Behavioral Therapies ◽  
New Treatments ◽  
Methamphetamine Use Disorder

: Almost two decades have passed since the last methamphetamine (METH) abuse epidemic. In recent years, METH abuse in the US has been rapidly increasing and is currently one of the leading causes of death in our country. Available statistical data indicates re-emergence of METH popularity and suggest an impending third epidemic of METH abuse. Alarmingly, there is no FDA- approved medication for METH use disorder (MUD). This disorder is currently treated with behavioral therapies; however, these therapies have limitations and would benefit from the addition of a MUD pharmacotherapy. Unfortunately, clinical trials have not yet found consistently effective pharmacotherapy for MUD. This review outlines the history of METH use, provides information on current prevalence of METH abuse and MUD, describes medications that have been in clinical trials for MUD, and addresses current as well as potential new treatments for MUD.

Cow's Milk Proteins Cause Infantile Colic in Breast-Fed Infants: A Double-Blind Crossover Study

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 268-271 ◽  
Author(s):  
Iréne Jakobsson ◽  
Tor Lindberg
Keyword(s):  
Whey Protein ◽  
Sequential Analysis ◽  
Protein A ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Infantile Colic ◽  
Double Blind ◽  
Milk Whey ◽  
Cow's Milk ◽  
Breast Fed

Sixty-six mothers of 66 breast-fed infants with infantile colic were put on a diet free from cow's milk. The colic disappeared in 35 infants; it reappeared on at least two challenges (cow's milk to mother) in 23 infants (35%). A double-blind crossover trial with cow's milk whey protein was performed in 16 of these 23 mothers and infants. Six infants had to be taken out of the study for various reasons; of the remaining ten infants, nine reacted with colic after their mothers' intake of whey protein-containing capsules. Sequential analysis showed a high correlation between infantile colic in breast-fed infants and their mothers' consumption of cow's milk protein. A diet free of cow's milk is suggested for the mothers as a first trial of treatment of infantile colic in breast-fed infants.

scholarly journals Severe Metabolic Acidosis: A Case of Triple Hit with Ketogenic Diet, Vinegar, and Metformin in an Obese Patient

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Abdul Mughees Rana ◽  
Kannan Mansoor ◽  
Salman Assad ◽  
Mahmoud Abouzid ◽  
Iheanyichukwu Ogu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Acetic Acid ◽  
Adverse Effects ◽  
Ketogenic Diet ◽  
Herbal Supplements ◽  
Dietary Practices ◽  
Over The Counter ◽  
Mainstream Media ◽  
Ketogenic Diets ◽  
Increased Risk

Obesity is an epidemic with high burden of disease. It is directly proportional to increased risk of morbidity and mortality. Ketogenic diet and herbal supplements have recently gained popularity amongst patients struggling with weight loss. There are limited data available for most of these supplements contrary to the claims laid by the mainstream media. Due to lack of awareness, this patient population is at high risk of adverse effects. We present a case of severe acidosis secondary to ketogenic diet and acetic acid (vinegar) ingestion. The use of dietary acetic acid is usually well tolerated; however, in this case, the large quantities and presence of acute renal injury and metformin use may have worsened the acidosis. Severe ketosis in setting of ketogenic diets is a serious complication, which is infrequently reported in literature. Many of these diets and supplements may seem harmless, but as our case illustrates, when combined with other risk factors, patients can face serious adverse effects and even require hospitalization. It is imperative that such dietary practices are physician supervised to avoid complications. With the recent surge of over-the-counter weight loss supplements and ketogenic diets, physicians also need to engage in dietary discussion with patients when attempting to lose weight.

Reversible cerebral vasoconstriction syndrome (RCVS) caused by over-the-counter calcium supplement ingestion

2021 ◽  
Vol 14 (1) ◽  
pp. e233877 ◽  
Author(s):  
Adam Ross Schertz ◽  
Anand Karthik Sarma ◽  
Sudhir Datar ◽  
Peter John Miller
Keyword(s):  
Serum Calcium ◽  
Pressure Control ◽  
Reversible Cerebral Vasoconstriction Syndrome ◽  
Albumin Concentration ◽  
Herbal Supplements ◽  
Over The Counter ◽  
Cerebral Angiogram ◽  
Cerebral Vasoconstriction ◽  
Ct Angiogram ◽  
Chronic Ingestion

A 59-year-old woman was found unresponsive at home. Initial neurologic examination revealed aphasia and right-sided weakness. Laboratory results demonstrated a serum calcium level of 17.3 mg/dL (corrected serum calcium for albumin concentration was 16.8 mg/dL). Extensive workup for intrinsic aetiology of hypercalcemia was unrevealing. Further discussion with family members and investigation of the patient’s home for over-the-counter medications and herbal supplements revealed chronic ingestion of calcium carbonate tablets. CT angiogram of the brain revealed multifocal intracranial vascular segmental narrowing, which resolved on a follow-up cerebral angiogram done 2 days later. These findings were consistent with reversible cerebral vasoconstriction syndrome.Appropriate blood pressure control with parenteral agents, calcium channel blockade with nimodipine and supportive care therapies resulted in significant improvement in neurologic status. By discharge, patient had near-complete resolution of neurologic symptoms.

Parkinson’s disease: Is there a role for dietary and herbal supplements?

2021 ◽  
Vol 20 ◽  
Author(s):  
Olakunle J. Onaolapo ◽  
Ademola O. Odeniyi ◽  
Adejoke Y. Onaolapo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dietary Supplements ◽  
Herbal Remedies ◽  
Key Factors ◽  
Herbal Supplements ◽  
Pharmacological Agents ◽  
Dopaminergic Pathway ◽  
High Doses ◽  
Nigrostriatal Dopaminergic Pathway

: Parkinson’s disease (PD) is characterised by degeneration of the neurons of the nigrostriatal dopaminergic pathway of the brain. The pharmacological cornerstone of PD management is mainly the use of dopamine precursors, dopamine receptor agonists, and agents that inhibit biochemical degradation of dopamine. While these drugs initially relief symptoms and improve the quality of life of patients, progression of the underlying pathological processes such as oxidative stress and neuroinflammation (which have been strongly associated with PD and other neurodegenerative disorders) eventually reduces their benefits; making further benefits now only achievable at high doses which amplify the magnitude and frequency of side-effects. Also, while it is becoming obvious that mainstream pharmacological agents may not always provide the much-needed answer, the question remains what succour can nature provide through dietary supplements, nutraceuticals and herbal remedies? This narrative review examines current literature for evidence of the possible roles (if any) of nutraceuticals, dietary supplements and herbal remedies in the prevention or management of PD, by examining how these compounds could modulate key factors and pathways that are crucial to the pathogenesis and/or progression of PD. The likely limitations of this approach and its possible future roles in PD prevention and management are also considered.

Cow's Milk Formula and Infantile Colic

PEDIATRICS ◽  
1989 ◽  
Vol 84 (6) ◽  
pp. 1124-1125
Author(s):  
WILLIAM B. CAREYMD
Keyword(s):  
Milk Proteins ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Double Blind Study ◽  
Milk Allergy ◽  
Infantile Colic ◽  
Double Blind ◽  
Cow's Milk ◽  
Young Infants ◽  
Excessive Crying

No experienced pediatric clinician doubts the existence of cow's milk allergy in infants. The controversy concerns how often cow's milk proteins cause excessive crying or "colic" in otherwise well young infants. Three interesting papers from our colleagues in Malmö, Sweden, leave the question unanswered despite the considerable sophistication in their research design. In their first report in 1982, they concluded that in a double-blind study "cow's milk seems to be a major cause of infantile colic in formula-fed infants." However, in the only part that was double-blind, fewer infants improved while receiving soy formula (18%) than did those receiving cow's milk formula (29%).

The Acute Effects of Nonstimulant Over-the-Counter Dietary Herbal Supplements on Resting Metabolic Rate

2015 ◽  
Vol 13 (4) ◽  
pp. 368-377
Author(s):  
Amanda J. Salacinski ◽  
Steven M. Howell ◽  
Danielle L. Hill ◽  
Steven M. Mauk
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Acute Effects ◽  
Herbal Supplements ◽  
Over The Counter

scholarly journals Neuroplasticity in addictive disorders

2009 ◽  
Vol 11 (3) ◽  
pp. 350-353
Keyword(s):  
Central Nervous System ◽  
Chronic Treatment ◽  
Reward System ◽  
Addictive Disorders ◽  
Conditioned Behavior ◽  
Behavioral Therapies ◽  
The Central Nervous System ◽  
Brain Changes ◽  
New Treatments ◽  
The Brain

Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leading to a drive toward drug-taking. The central nervous system changes underlying this conditioned behavior are just beginning to be understood. New treatments aimed at this neuroplasticity are being tested in animal models. The clinical significance of these brain changes is that addiction, once established, becomes a chronic illness with relapses and remissions. It therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain.

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