scholarly journals Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

2014 ◽  
Author(s):  
Stephanie B Stewart ◽  
Jonathan M Koller ◽  
Meghan C Campbell ◽  
Joel S Perlmutter ◽  
Kevin J Black
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Image Quality ◽  
Arterial Spin Labeling ◽  
Statistical Significance ◽  
Spin Labeling ◽  
Cortical Activation ◽  
Affect Image Quality ◽  
Global Cerebral Blood Flow ◽  
Multiplicative Normalization

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.

scholarly journals Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

2014 ◽  
Author(s):  
Stephanie B Stewart ◽  
Jonathan M Koller ◽  
Meghan C Campbell ◽  
Joel S Perlmutter ◽  
Kevin J Black
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Image Quality ◽  
Arterial Spin Labeling ◽  
Statistical Significance ◽  
Spin Labeling ◽  
Cortical Activation ◽  
Affect Image Quality ◽  
Global Cerebral Blood Flow ◽  
Multiplicative Normalization

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.

scholarly journals Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

2014 ◽  
Author(s):  
Stephanie B Stewart ◽  
Jonathan M Koller ◽  
Meghan C Campbell ◽  
Joel S Perlmutter ◽  
Kevin J Black
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Image Quality ◽  
Arterial Spin Labeling ◽  
Visual Inspection ◽  
Statistical Significance ◽  
Spin Labeling ◽  
Cortical Activation ◽  
Global Cerebral Blood Flow ◽  
Multiplicative Normalization

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization by visual inspection, by comparing intensity histograms, and by reduction of the variability within gray and white matter.

scholarly journals Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

2014 ◽  
Author(s):  
Stephanie B Stewart ◽  
Jonathan M Koller ◽  
Meghan C Campbell ◽  
Joel S Perlmutter ◽  
Kevin J Black
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Image Quality ◽  
Arterial Spin Labeling ◽  
Visual Inspection ◽  
Statistical Significance ◽  
Spin Labeling ◽  
Cortical Activation ◽  
Global Cerebral Blood Flow ◽  
Multiplicative Normalization

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization by visual inspection, by comparing intensity histograms, and by reduction of the variability within gray and white matter.

Automated removal of spurious intermediate cerebral blood flow volumes improves image quality among older patients: A clinical arterial spin labeling investigation

2015 ◽  
Vol 42 (5) ◽  
pp. 1377-1385 ◽  
Author(s):  
Zahra Shirzadi ◽  
David E. Crane ◽  
Andrew D. Robertson ◽  
Pejman J. Maralani ◽  
Richard I. Aviv ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Image Quality ◽  
Older Patients ◽  
Arterial Spin Labeling ◽  
Spin Labeling

scholarly journals Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort

2016 ◽  
Vol 36 (7) ◽  
pp. 1244-1256 ◽  
Author(s):  
Sudipto Dolui ◽  
Ze Wang ◽  
Danny JJ Wang ◽  
Raghav Mattay ◽  
Mack Finkel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Phase Contrast ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Entire Cohort ◽  
Non Invasive ◽  
Global Cerebral Blood Flow ◽  
Continuous Arterial Spin Labeling

Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects acquired at two sites in the NHLBI CARDIA multisite study. Cerebral blood flow measured by phase contrast (CBFPC: 55.76 ± 12.05 ml/100 g/min) was systematically higher ( p < 0.001) and more variable than cerebral blood flow measured by pseudo-continuous arterial spin labeling (CBFPCASL: 47.70 ± 9.75). The correlation between global cerebral blood flow values obtained from the two modalities was 0.59 ( p < 0.001), explaining less than half of the observed variance in cerebral blood flow estimates. Well-established correlations of global cerebral blood flow with age and sex were similarly observed in both CBFPCASL and CBFPC. CBFPC also demonstrated statistically significant site differences, whereas no such differences were observed in CBFPCASL. No consistent velocity-dependent effects on pseudo-continuous arterial spin labeling were observed, suggesting that pseudo-continuous labeling efficiency does not vary substantially across typical adult carotid and vertebral velocities, as has previously been suggested. Conclusions: Although CBFPCASL and CBFPC values show substantial similarity across the entire cohort, these data do not support calibration of CBFPCASL using CBFPC in individual subjects. The wide-ranging cerebral blood flow values obtained by both methods suggest that cerebral blood flow values are highly variable in the general population.

scholarly journals Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e834 ◽  
Author(s):  
Stephanie B. Stewart ◽  
Jonathan M. Koller ◽  
Meghan C. Campbell ◽  
Joel S. Perlmutter ◽  
Kevin J. Black
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Perfusion Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Global Cerebral Blood Flow
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