scholarly journals Head motion in children with ADHD during resting-state brain imaging

2014 ◽  
Author(s):  
Xiang-zhen Kong
Keyword(s):  
Resting State ◽  
Cross Validation ◽  
Head Motion ◽  
Adhd Group ◽  
Typically Developing ◽  
Clinical Factors ◽  
Children With Adhd ◽  
Technical Artifacts ◽  
Motion Parameters ◽  
Scanning Motion

Although head motion during scanning has been largely considered to reflect simply technical artifacts, there is growing evidence showing that the variable of head motion reflects valuable information regarding individual’s psychological and/or clinical factors. Detailed studies would not only help to deal with the head motion biases, but they also help researchers in understanding the mental disorders. In this study, children with ADHD and demographically-matched typically developing control (TDC) participants underwent rs-fMRI examination without any specific task, and six mean single head motion parameters (three translational and three rotational) and a summary motion index for each participant were obtained. We found that patients with ADHD showed specific patterns of head motion during scanning: motion was significantly increased in the ADHD group, which was mainly contributed by the motion around and along the superior-to-inferior direction. Furthermore, the cross-validation classification analyses showed that the head motion could accurately distinguish children with ADHD from the healthy controls. These results suggest that head motion during scanning reflects useful information about the participants and accounting for head motion from MRI data may be helpful for ADHD diagnosing and treatment with neuroimaging.

scholarly journals Head motion in children with ADHD during resting-state brain imaging

2014 ◽  
Author(s):  
Xiang-zhen Kong
Keyword(s):  
Resting State ◽  
Cross Validation ◽  
Head Motion ◽  
Adhd Group ◽  
Typically Developing ◽  
Clinical Factors ◽  
Children With Adhd ◽  
Technical Artifacts ◽  
Motion Parameters ◽  
Scanning Motion

Although head motion during scanning has been largely considered to reflect simply technical artifacts, there is growing evidence showing that the variable of head motion reflects valuable information regarding individual’s psychological and/or clinical factors. Detailed studies would not only help to deal with the head motion biases, but they also help researchers in understanding the mental disorders. In this study, children with ADHD and demographically-matched typically developing control (TDC) participants underwent rs-fMRI examination without any specific task, and six mean single head motion parameters (three translational and three rotational) and a summary motion index for each participant were obtained. We found that patients with ADHD showed specific patterns of head motion during scanning: motion was significantly increased in the ADHD group, which was mainly contributed by the motion around and along the superior-to-inferior direction. Furthermore, the cross-validation classification analyses showed that the head motion could accurately distinguish children with ADHD from the healthy controls. These results suggest that head motion during scanning reflects useful information about the participants and accounting for head motion from MRI data may be helpful for ADHD diagnosing and treatment with neuroimaging.

scholarly journals Head motion in children with ADHD during resting-state brain imaging

2014 ◽  
Author(s):  
Xiang-zhen Kong
Keyword(s):  
Resting State ◽  
Head Motion ◽  
Control Group ◽  
Adhd Group ◽  
Typically Developing ◽  
Children With Adhd ◽  
Neural Imaging ◽  
Hyperactivity Disorder ◽  
Healthy Control ◽  
Motion Parameters

Resting-state functional MRI (rs-fMRI) has become an important method for analyzing the neural mechanisms underlying mental disorders. But studies targeting head motion during an rs-fMRI examination are rare. Since head motion may pollute the data in the neural imaging studies and further mislead the understanding of the causes of some disorders, systematic investigations on this topic were badly needed. To this end, in this study, children with attention-deficit/hyperactivity disorder (ADHD) and demographically-matched typically developing control (TDC) participants underwent an rs-fMRI examination. We obtained a summary motion index and six mean single head motion parameters (three translational and three rotational) for each participant. With the summary index, we found that motion was significantly increased in the ADHD group and the results showed that the increase was mainly contributed by the motion around and along the superior-to-inferior direction. Moreover, the classification analysis showed that these head motion parameters during scanning could accurately distinguish children with ADHD from the healthy control group. These results suggest that accounting for head motion during scanning may be helpful for ADHD diagnosis and treatment with neuroimaging.

scholarly journals Event-Based Prospective Memory Deficit in Children with ADHD: Underlying Cognitive Factors and Association with Symptoms

2021 ◽  
Vol 18 (11) ◽  
pp. 5849
Author(s):  
Floriana Costanzo ◽  
Elisa Fucà ◽  
Deny Menghini ◽  
Antonella Rita Circelli ◽  
Giovanni Augusto Carlesimo ◽  
...  
Keyword(s):  
Prospective Memory ◽  
Positive Influence ◽  
Attentional Focus ◽  
Adhd Group ◽  
Typically Developing ◽  
Children With Adhd ◽  
The Road ◽  
Hyperactivity Disorder ◽  
Event Based

Event-based prospective memory (PM) was investigated in children with Attention deficit/hyperactivity disorder (ADHD), using a novel experimental procedure to evaluate the role of working memory (WM) load, attentional focus, and reward sensitivity. The study included 24 children with ADHD and 23 typically-developing controls. The experimental paradigm comprised one baseline condition (BC), only including an ongoing task, and four PM conditions, varying for targets: 1 Target (1T), 4 Targets (4T), Unfocal (UN), and Reward (RE). Children with ADHD were slower than controls on all PM tasks and less accurate on both ongoing and PM tasks on the 4T and UN conditions. Within the ADHD group, the accuracy in the RE condition did not differ from BC. A significant relationship between ADHD-related symptoms and reduced accuracy/higher speed in PM conditions (PM and ongoing trials), but not in BC, was detected. Our data provide insight on the adverse role of WM load and attentional focus and the positive influence of reward in the PM performance of children with ADHD. Moreover, the relation between PM and ADHD symptoms paves the road for PM as a promising neuropsychological marker for ADHD diagnosis and intervention.

scholarly journals Development of Hot and Cold Executive Function in Boys and Girls With ADHD

2016 ◽  
Vol 21 (4) ◽  
pp. 305-315 ◽  
Author(s):  
Erik Winther Skogli ◽  
Per Normann Andersen ◽  
Kjell Tore Hovik ◽  
Merete Øie
Keyword(s):  
Executive Function ◽  
Developmental Trajectories ◽  
Phenotypic Traits ◽  
Adhd Group ◽  
Typically Developing ◽  
Test Results ◽  
Children With Adhd ◽  
Emotional Salience ◽  
Girls With Adhd

Objective: To investigate the development of executive function with pronounced emotional salience (hot EF) and less pronounced emotional salience (cold EF) in boys and girls with ADHD relative to typically developing (TD) children. Method: Seventy-five children with ADHD and 47 TD children were assessed with hot and cold EF tests at baseline and after 2 years. Results: Despite considerable maturation, the ADHD group remained impaired on all cold EF tests relative to TD children after 2 years. There was no effect of gender on cold EF test results. Females with ADHD outperformed TD counterparts on hot EF at baseline. Females with ADHD showed deteriorating hot EF performance, while TD counterparts showed improved hot EF performance across time. Conclusion: Enduring cold EF impairments after 2 years may reflect stable phenotypic traits in children with ADHD. Results indicate divergent developmental trajectories of hot EF in girls with ADHD relative to TD counterparts.

scholarly journals Transient arousal modulations contribute to resting-state functional connectivity changes associated with head motion parameters

2018 ◽  
Author(s):  
Yameng Gu ◽  
Feng Han ◽  
Lucas E. Sainburg ◽  
Xiao Liu
Keyword(s):  
Resting State ◽  
Template Matching ◽  
Brain Connectivity ◽  
Head Motion ◽  
Resting State Functional Connectivity ◽  
Time Points ◽  
Motion Time ◽  
Health And Disease ◽  
Motion Parameters ◽  
Proper Interpretation

AbstractCorrelations of resting-state functional magnetic resonance imaging (rsfMRI) signals are being widely used for assessing functional brain connectivity in health and disease. However, an association was recently observed between rsfMRI connectivity modulations and the head motion parameters and regarded as a causal relationship, which has raised serious concerns about the validity of many rsfMRI findings. Here, we studied the origin of this rsfMRI-motion association and its relationship to arousal modulations. By using a template-matching method to locate arousal-related fMRI changes, we showed that the effects of high motion time points on rsfMRI connectivity are largely due to their significant overlap with arousal-affected time points. The finding suggests that the association between rsfMRI connectivity and the head motion parameters arises from their co-modulations at transient arousal modulations, and this information is critical not only for proper interpretation of motion-associated rsfMRI connectivity changes but also for controlling the potential confounding effects of arousal modulation on rsfMRI metrics.

scholarly journals Transient Arousal Modulations Contribute to Resting-State Functional Connectivity Changes Associated with Head Motion Parameters

2020 ◽  
Vol 30 (10) ◽  
pp. 5242-5256 ◽  
Author(s):  
Yameng Gu ◽  
Feng Han ◽  
Lucas E Sainburg ◽  
Xiao Liu
Keyword(s):  
Resting State ◽  
Template Matching ◽  
Brain Connectivity ◽  
Head Motion ◽  
Resting State Functional Connectivity ◽  
Time Points ◽  
Motion Time ◽  
Health And Disease ◽  
Motion Parameters ◽  
Proper Interpretation

Abstract Correlations of resting-state functional magnetic resonance imaging (rsfMRI) signals are being widely used for assessing the functional brain connectivity in health and disease. However, an association was recently observed between rsfMRI connectivity modulations and the head motion parameters and regarded as a causal relationship, which has raised serious concerns about the validity of many rsfMRI findings. Here, we studied the origin of this rsfMRI-motion association and its relationship to arousal modulations. By using a template-matching method to locate arousal-related fMRI changes, we showed that the effects of high motion time points on rsfMRI connectivity are largely due to their significant overlap with arousal-affected time points. The finding suggests that the association between rsfMRI connectivity and the head motion parameters arises from their comodulations at transient arousal modulations, and this information is critical not only for proper interpretation of motion-associated rsfMRI connectivity changes, but also for controlling the potential confounding effects of arousal modulation on rsfMRI metrics.

scholarly journals Motor competence difficulties and attention deficit and hyperactivity disorder (ADHD) among secondary students

2020 ◽  
Vol 20 (2) ◽  
pp. 47-62
Author(s):  
Miguel Villa ◽  
María Isabel Barriopedro Moro ◽  
Luis Miguel Ruiz Pérez
Keyword(s):  
At Risk ◽  
Executive Functions ◽  
Motor Skill ◽  
Child Behavior Checklist ◽  
Motor Coordination ◽  
Attention Problems ◽  
Adhd Group ◽  
Typically Developing ◽  
Motor Competence ◽  
Children With Adhd

A high proportion of children with Attention problems (ADHD) experience motor competence problems. The present study sought to compare the motor competence between a group of ADHD students and a normative sample before and after controlling for motor coordination problems, and check if there are differences between the group with ADHD and the group with DT, depending on the presence or not of the DCD concurrent with the ADHD.  A total of 22 children with ADHD combined type (ADHD-CT; 12–13 years, SD 0.7, 16 males, 6 females) and 23 age-matched typically developing children with no movement difficulties (12-13 years, SD 0.7 16 males, 7 females) participated in this study. Motor coordination was measured using the Movement Assessment Battery for Children-2nd Edition (MABC-2). ADHD symptoms were assessed by the school’s Department of Psychology.The ADHD diagnosis is based on  diagnostic criteria established by the Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5), and the application of the following behavioral scales and evaluation of executive functions have been followed: Child Behavior Checklist for ages; Behavior Ratting Inventory of Executive Functions (BRIEF); Scales for the Evaluation of ADHD (EDAH). Based on the MABC-2 score (percentile score ≤ 5th), ADHD children were classified into two groups: co-occurring DCD/ADHD and ADHD group. Results showed that children with ADHD and typically developing (TD) children showed big individual differences on all motor skill areas and on overall percentile scores. Thirteen children with ADHD were delayed, and three were at risk for motor delays. Only four TD children were at risk for motor delays. DCD/ADHD group scored significantly lower than the TD group across all motor skill areas, while ADHD group scored lower than the TD group only on manual dexterity.

Using Metacognitive Methods to Examine Emotion Recognition in Children With ADHD

2018 ◽  
Vol 25 (2) ◽  
pp. 245-257
Author(s):  
Alexandra Basile ◽  
Maggie E. Toplak ◽  
Brendan F. Andrade
Keyword(s):  
Executive Function ◽  
Emotion Recognition ◽  
Task Performance ◽  
Group Differences ◽  
Adhd Group ◽  
Typically Developing ◽  
Specific Task ◽  
Adhd Symptoms ◽  
Typically Developing Children ◽  
Children With Adhd

Objective: This study investigated confidence accuracy associations for emotion recognition (ER) in children with ADHD and typically developing children (TD). Method: Thirty-nine children with ADHD and 42 TD ( M = 9 years, 11 months, SD = 14.92 months, 26 females) completed an ER task. Intelligence and executive function task performance were also measured. Results: The ADHD group was more confident on ER compared with TD, but no group differences were found on their overall accuracy. Specifically, the ADHD group was more confident in its recognition of sad and angry faces compared with the TD group. On a metacognitive index, the ADHD group displayed lower resolution, suggesting that the TD group was better at discriminating correct from incorrect responses. Higher resolution was associated with lower ADHD symptoms. Conclusion: Confidence ratings with reference to performance on a specific task can provide an index of social-cognition in children with ADHD.

scholarly journals EEG power spectral slope differs by ADHD status and stimulant medication exposure in early childhood

2019 ◽  
Vol 122 (6) ◽  
pp. 2427-2437 ◽  
Author(s):  
Madeline M. Robertson ◽  
Sarah Furlong ◽  
Bradley Voytek ◽  
Thomas Donoghue ◽  
Charlotte A. Boettiger ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Power Spectrum ◽  
Attention Deficit ◽  
Resting State ◽  
Typically Developing ◽  
Spectral Slope ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Eeg Power Spectrum ◽  
Eeg Power

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by hyperactivity/impulsivity and inattentiveness. Efforts toward the development of a biologically based diagnostic test have identified differences in the EEG power spectrum; most consistently reported is an increased ratio of theta to beta power during resting state in those with the disorder, compared with controls. Current approaches calculate theta/beta ratio using fixed frequency bands, but the observed differences may be confounded by other relevant features of the power spectrum, including shifts in peak oscillation frequency and altered slope or offset of the aperiodic 1/ f-like component of the power spectrum. In the present study, we quantify the spectral slope and offset, peak alpha frequency, and band-limited and band-ratio oscillatory power in the resting-state EEG of 3- to 7-yr-old children with and without ADHD. We found that medication-naive children with ADHD had higher alpha power, greater offsets, and steeper slopes compared with typically developing children. Children with ADHD who were treated with stimulants had comparable slopes and offsets to the typically developing group despite a 24-h medication-washout period. We further show that spectral slope correlates with traditional measures of theta/beta ratio, suggesting the utility of slope as a neural marker over and above traditional approaches. Taken with past research demonstrating that spectral slope is associated with executive functioning and excitatory/inhibitory balance, these results suggest that altered slope of the power spectrum may reflect pathology in ADHD. NEW & NOTEWORTHY This article highlights the clinical utility of comprehensively quantifying features of the EEG power spectrum. Using this approach, we identify, for the first time, differences in the aperiodic components of the EEG power spectrum in children with attention-deficit/hyperactivity disorder (ADHD) and provide evidence that spectral slope is a robust indictor of an increase in low- relative to high-frequency power in ADHD.

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