scholarly journals Data Rate Theorem perspectives on the contribution of extrinsic risk factors to cancer development

Author(s):  
Rodrick Wallace

We explore environmentally-induced tumors in the context of the ongoing conflict between long-evolved cancer control mechanisms and the central flaw of multicellularity, using a number of convergent necessary conditions statistical models based on the Data Rate Theorem linking control and information theories. Multicellular cancer suppression is an inherently unstable dynamic process that can fail through sufficient environmental insult, in particular for humans, involving the synergism of chemical exposures with the chronic inflammation of 'social' exposures that may be seen as accelerated aging.

2016 ◽  
Author(s):  
Rodrick Wallace

We explore environmentally-induced tumors in the context of the ongoing conflict between long-evolved cancer control mechanisms and the central flaw of multicellularity, using a number of convergent necessary conditions statistical models based on the Data Rate Theorem linking control and information theories. Multicellular cancer suppression is an inherently unstable dynamic process that can fail through sufficient environmental insult, in particular for humans, involving the synergism of chemical exposures with the chronic inflammation of 'social' exposures that may be seen as accelerated aging.


2013 ◽  
Author(s):  
Rodrick Wallace

AbstractThe Data Rate Theorem carries deep implications for theories of embodied cognition, extensions providing a spectrum of necessary conditions dynamic statistical models useful in empirical studies. A large deviations argument, however, implies that the regulation and stabilization of such systems is itself an interpenetrating phenomenon necessarily convoluted with embodied cognition. For humans, the central regulatory role of culture has long been known. Although a ground-state collapse analogous to generalized anxiety appears ubiquitous to such systems, lack of cultural modulation in real-time automatons or distributed cognition man-machine ‘cockpits’ makes them subject to a pathology under which ‘all possible targets are enemies’.


2013 ◽  
Vol 427-429 ◽  
pp. 2864-2869
Author(s):  
Zhi Ren ◽  
Ya Nan Cao ◽  
Shuang Peng ◽  
Hong Jiang Lei

The terahertz wave is a kind of electromagnetic waves which locates between millimeter waves and infrared lightwaves, and the frequency range is 0.14THz~10THz. Terahertz is used as a carrier wave to communicate with each other because it has large bandwidth which can support Gbps wireless data rates. Therefore, terahertz communication technologies become research hot spots in recent years. However, its still rare in MAC protocol of terahertz ultra-high data-rate wireless networks at present. In order to realize wireless access of ultra-high data-rate under the condition of terahertz carrier frequency, a novel MAC protocol is proposed in this paper. The improved MAC protocol which makes the maximum data rates reach up to 10Gbps or higher is designed by new MAC control mechanisms, new time-slots allocation schemes and new superframe structure. Theoretical analysis and simulation results show that the new proposed MAC protocol of terahertz ultra-high data-rate wireless networks can operation normally, and the maximum data rate can reach up to 19.2Gbps. This maximum data rate is 2 times higher than 5.78 Gbps which IEEE 802.15.3c can achieve.


Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 28 ◽  
Author(s):  
Bridget Baxter ◽  
Renee Oppel ◽  
Elizabeth Ryan

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States and emerging evidence supports that increased consumption of legumes, such as navy beans, can reduce risk. Navy bean consumption was previously shown to modulate host and microbiome metabolism, and this investigation was performed to assess the impact on the human stool metabolome, which includes the presence of navy bean metabolites. This 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily. The intervention contained 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18). There were 30 statistically significant metabolite differences in the stool of participants that consumed navy bean at day 28 compared to the participants’ baseline (p ≤ 0.05) and 26 significantly different metabolites when compared to the control group. Of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites that were identified in the stool of participants consuming navy beans, such as N-methylpipecolate, 2-aminoadipate, piperidine, and vanillate. The microbial metabolism of amino acids and fatty acids were also identified in stool after 4 weeks of navy bean intake including cadaverine, hydantoin-5 propionic acid, 4-hydroxyphenylacetate, and caprylate. The stool relative abundance of ophthalmate increased 5.25-fold for navy bean consumers that can indicate glutathione regulation, and involving cancer control mechanisms such as detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis. Metabolic pathways involving lysine, and phytochemicals were also modulated by navy bean intake in CRC survivors. These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merit further investigation for improving colonic health after long-term consumption.


2022 ◽  
Vol 2161 (1) ◽  
pp. 012018
Author(s):  
M Deeksha ◽  
Ashish Patil ◽  
Muralidhar Kulkarni ◽  
N. Shekar V. Shet ◽  
P. Muthuchidambaranathan

Abstract Vehicular ad hoc networks (VANETs) have emerged in time to reduce on-road fatalities and provide efficient information exchange for entertainment-related applications to users in a well-organized manner. VANETs are the most instrumental elements in the Internet of Things (IoT). The objective lies in connecting every vehicle to every other vehicle to improve the user’s quality of life. This aim of continuous connectivity and information exchange leads to the generation of more information in the medium, which could congest the medium to a larger extent. Decentralized congestion control (DCC) techniques are specified to reduce medium congestion and provide various safety applications. This article presents two DCC mechanisms that adapt message rate and data rate combined with transmit power control mechanism. These mechanisms are developed under multi-state active design proposed by the standard. The proposed methods deliver better performance over other mechanisms in terms of power, channel load, and channel utilization using real-time-based scenarios by simulation in SUMO.


Author(s):  
Eduardo Cazap ◽  
Gilberto Schwartsmann

Abstract: A lack of epidemiological data and political commitment was the conclusion of a study about breast cancer in Latin America. The available data show a 5-year survival rate in Latin America fluctuating around 70%. Healthcare coverage is expanding, although not across all dimensions. There remain vast differences in access to care. The economic burden is significant, while countries allocate insufficient resources to tackle the disease. Many Latin American countries (LACs) have no formal national cancer control programmes in place to define the critical processes. Guidelines exists, but the challenge is implementation. A big issue in LACs is the having in place the right policies and control mechanisms to ensure compliance and applicability for the entire population.


2011 ◽  
Vol 9 (1) ◽  
pp. 491-502
Author(s):  
Boutheina Regaieg ◽  
Meriam Ben Abdallah

This paper examines the specificities of the governance system in Tunisian companies through the remuneration policy for executives, the board and the ownership structure in the period before the revolution. The purpose of this work is to identify possible dysfunctions and subsequently propose ways of to rehabilitate governance mechanisms and optimize their effectiveness. The agency theory identifies the necessary conditions for effective controlling. Empirical validation on a panel of 30 Tunisian companies listed on the Tunis Stock Exchange and observed for two years (between 2008 and 2009), Shows firstly that the policy of executive compensation is not a mechanism for effective governance, and secondly that the impact of internal control mechanisms on performance, through its components, seems mixed.


Author(s):  
A. E. Vatter ◽  
J. Zambernard

Oncogenic viruses, like viruses in general, can be divided into two classes, those that contain deoxyribonucleic acid (DNA) and those that contain ribonucleic acid (RNA). The RNA viruses have been recovered readily from the tumors which they cause whereas, the DNA-virus induced tumors have not yielded the virus. Since DNA viruses cannot be recovered, the bulk of present day investigations have been concerned with RNA viruses.The Lucké renal adenocarcinoma is a spontaneous tumor which occurs in northern leopard frogs (Rana pipiens) and has received increased attention in recent years because of its probable viral etiology. This hypothesis was first advanced by Lucké after he observed intranuclear inclusions in some of the tumor cells. Tumors with inclusions were examined at the fine structural level by Fawcett who showed that they contained immature and mature virus˗like particles.The use of this system in the study of oncogenic tumors offers several unique features, the virus has been shown to contain DNA and it can be recovered from the tumor, also, it is temperature sensitive. This latter feature is of importance because the virus can be transformed from a latent to a vegetative state by lowering or elevating the environmental temperature.


1977 ◽  
Vol 113 (2) ◽  
pp. 193-195 ◽  
Author(s):  
H. T. Lynch

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