Clinical Approach to Acute Iron Poisoning: Case Series

2013 ◽  
Keyword(s):  
Case Series ◽  
Clinical Approach ◽  
Poisoning Case ◽  
Iron Poisoning

scholarly journals Hyperferritinemia in patients with nonalcoholic fatty liver disease

2017 ◽  
Vol 63 (3) ◽  
pp. 284-289 ◽  
Author(s):  
Raffaelle K Barros ◽  
Helma Pinchemel Cotrim ◽  
Carla H Daltro ◽  
Yanaihara A Oliveira
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Diseases ◽  
Elevated Serum ◽  
Case Series ◽  
Clinical Approach ◽  
Retrospective Case ◽  
Nonalcoholic Fatty Liver

Summary Objective: In liver diseases, hyperferritinemia (HYF) is related to injured cells in acquired and genetic conditions with or without iron overload. It is frequent in patients with nonalcoholic fatty liver disease (NAFLD), in which it is necessary to define the mean of HYF to establish the better approach for them. The present study evaluated the significance of elevated ferritin in patients with NAFLD and steatohepatitis (NASH). Method: The review was performed using search instruments of indexed scientific material, including MEDLINE (by PubMed), Web of Science, IBECS and LILACS, to identify articles published in Portuguese, English and Spanish, from 2005 to May, 2016. Studies eligible included place and year of publication, diagnose criteria to NAFLD, specifications of serum ferritin measurements and/or liver histopathologic study. Exclusion criteria included studies with patients with alcohol consumption ≥ 20 g/day and other liver diseases. Results: A total of 11 from 30 articles were selected. It included 3,564 patients and they were cross-sectional, retrospective, case series and case-control. The result's analyses showed in 10 of these studies a relationship between ferritin elevated serum levels and NAFLD/NASH with and without fibrosis and insulin resistance. Conclusion: Hyperferritinemia in patients with NAFLD/NASH is associated more frequently with hepatocellular injury than hemochromatosis. These data suggest the relevance to evaluate carefully HYF in patients with NAFLD/NASH to establish appropriate clinical approach.

scholarly journals Novel mutations in NOTCH2 gene in infants with neonatal cholestasis

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Eliana Shaul ◽  
Debora Kogan-Liberman ◽  
Stephanie Schuckalo ◽  
Dominique Jan ◽  
Michelle Ewart ◽  
...  
Keyword(s):  
Case Series ◽  
Alagille Syndrome ◽  
Notch Signaling Pathway ◽  
Clinical Approach ◽  
Neonatal Cholestasis ◽  
Retrospective Case ◽  
Variants Of Unknown Significance ◽  
Intrahepatic Bile Ducts ◽  
Sorting Intolerant From Tolerant ◽  
Unknown Significance

One cause of neonatal cholestasis (NC) is paucity of intrahepatic bile ducts which can be associated with Alagille syndrome or non- syndromic. Alagille syndrome is caused by autosomal dominant mutations in the Notch signaling pathway ligand Jagged1 in 94% of patients and mutations in the NOTCH2 receptor in <1% of patients. This is a retrospective case series studying infants with neonatal cholestasis found to have variants of unknown significance (VOUS) in NOTCH2. Sorting intolerant from tolerant (SIFT) and polymorphism phenotyping (PolyPhen) were utilized to predict a damaging effect. Five infants with NC without other features of Alagille syndrome were found to have one copy of a VOUS in NOTCH2, predicted to be damaging by SIFT and PolyPhen. Our cases support the notion that NOTCH2 mutations may result in hypoplastic biliary system. Further characterization of these variants is important to assist with our clinical approach to NC.

scholarly journals Optic disc pit maculopathy – case series, clinical approach, and management

2020 ◽  
Vol 27 (1) ◽  
pp. 34
Author(s):  
Dimitrios Kalogeropoulos ◽  
SoonWai Ch'ng ◽  
Rynn Lee ◽  
Ibrahim Elaraoud ◽  
Vinaya Felicida ◽  
...  
Keyword(s):  
Optic Disc ◽  
Case Series ◽  
Clinical Approach ◽  
Optic Disc Pit ◽  
Optic Disc Pit Maculopathy

Unintentional paediatric iron poisoning: A retrospective case series

2021 ◽  
Author(s):  
Andrew K Crofton ◽  
Keith Harris ◽  
Carol Wylie ◽  
Katherine Z Isoardi
Keyword(s):  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Iron Poisoning

scholarly journals Congenital complete atrioventricular block from literature to clinical approach – a case series and literature review

2020 ◽  
Author(s):  
Liliana Gozar ◽  
Claudiu Marginean ◽  
Amalia Fagarasan ◽  
Iolanda Muntean ◽  
Andreea Cerghit-Paler ◽  
...  
Keyword(s):  
Ventricular Function ◽  
Atrioventricular Block ◽  
Speckle Tracking ◽  
Pacemaker Implantation ◽  
Case Series ◽  
Clinical Approach ◽  
Intrauterine Death ◽  
Congenital Atrioventricular Block ◽  
Therapeutic Behavior

Aim: Congenital atrioventricular block (CAVB) is an immunological condition, secondary to the transfer of maternal Ig G antibodies from seropositive mothers. Although the presence of these antibodies is high among pregnant women, the preva-lence of this fetal pathology is low. The aim of this paper is to analyze a series of cases with intrauterine diagnosis of CAVB and to present their follow-up protocol. Material and method: In the period between 2013-2020, five fetuses were diagnosed and followed up in the Pediatric Cardiology Clinic. In each of the cases, assessment of the hemodynamic status was done by calculation of the fetal cardiovascular profile score (CVPS). In the last cases the follow-up protocol was supplemented with longitudinal speckle tracking evaluation of the ventricular function. Results: In the present series, intrauterine death occurred in one case; in another case resumption of atrioventricular conduction was observed. Epicardial pacemaker implantation was required in three of the patients. Conclusion: Completing the evaluation of ventricular function with the longitudinal speckle tracking method in fetuses and newborn patients with congenital atrioventricular block may play an important role in establish-ing therapeutic behavior.

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2—Case Series of a Pediatric Intensive Care Unit in Portugal

2021 ◽  
Author(s):  
João Miranda ◽  
Marta Grilo ◽  
Carolina Baptista ◽  
Ana Reis e Melo ◽  
Margarida Tavares ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Invasive Mechanical Ventilation ◽  
Ventilatory Support ◽  
Case Series ◽  
Pediatric Intensive Care ◽  
Left Ventricular ◽  
Clinical Approach ◽  
High Flow Oxygen

AbstractPediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) is a novel condition with persistent fever, inflammation, and single or multiorgan dysfunction. We aimed to describe the characteristics of children more severely affected and our clinical approach. We retrospectively collected clinical, treatment, and early outcomes data during a 3-month period in a pediatric intensive care unit (PICU) of a tertiary university hospital in Portugal. Twelve children who fulfilled the Royal College of Pediatrics and Child Health case definition were hospitalized, seven needed PICU admission. Median age was 13 years and three were overweight, with no other comorbidity. All had positive immunoglobulin G antibodies for SARS-CoV-2. All presented with prolonged fever, asthenia, hypotension, and shock. Other prominent symptoms were abdominal complaints and rash. All patients had leukocytosis, neutrophilia, and marked elevation of inflammatory markers. Cardiac involvement was observed in all patients with elevated levels of troponin and B-type natriuretic peptide along with left ventricular hypokinesis. Depressed left ventricular function was observed in four patients. All patients received broad-spectrum antibiotics, intravenous immunoglobulin, methylprednisolone, low-dose aspirin, and vasoactive medications. Four patients received prophylactic enoxaparin. All patients needed supplementary oxygen; however, high-flow oxygen therapy and noninvasive ventilatory support with positive end-expiratory pressure were required in three and two patients, respectively. Five patients required invasive mechanical ventilation. The mean duration of PICU stay was 7.1 days. The median Pediatric Risk of Mortality-III score was 9 and no mortality was observed. PIMS-TS demands a prompt and multidisciplinary approach. Risk factors, best clinical pathway, and long-term complications are still unknown.

scholarly journals Histochemistry based confirmation of the diagnosis of Copper Sulphate Poisoning: Case-Series

2020 ◽  
Vol 16 (1) ◽  
pp. 35
Author(s):  
Arindam Chakrovarty ◽  
Ranajoy Ghosh ◽  
Anadi Roychowdhury ◽  
Suddhodhan Batabyal ◽  
Rina Das
Keyword(s):  
Copper Sulphate ◽  
Case Series ◽  
Poisoning Case
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