scholarly journals Tinea capitis mimicking alopecia areata

2021 ◽  
Vol 12 (1) ◽  
pp. 40-43
Author(s):  
Saber Dooqaei Moqadam ◽  
Ramina Mofarrah ◽  
Kousar Jahani Amiri ◽  
Fatemeh Montazer ◽  
Anahita Barqi ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Tinea Capitis ◽  
Clinical Signs ◽  
Punch Biopsy ◽  
Causative Organism ◽  
Clinical Appearance ◽  
Clinical Benefits ◽  
Host Inflammatory Response

Tinea capitis (TC) is the most common dermatophyte scalp infection in children and an unusual dermatophytosis in adults. The clinical appearance of tinea capitis is highly variable and depends on the causative organism, type of hair invasion, and degree of the host inflammatory response. The commonly observed features are patchy hair loss with varying degrees of scaling and erythema. The clinical signs may be subtle and diagnosis may be challenging. We report the case of an adult patient with tinea capitis mimicking alopecia areata. The patient was initially diagnosed with alopecia areata and completed one month of treatment without clinical benefits. In view of no clinical signs of tinea capitis, a biopsy was performed. A scalp punch biopsy revealed an endothrix dermatophytosis. The patient’s medication was switched to 250 mg terbinafine daily for 8 weeks and 2% ketoconazole shampoo. The patient completed two months of therapy with maintenance of hair regrowth and resolution of symptoms and scales.

scholarly journals Different Trichoscopic Features of Tinea Capitis and Alopecia Areata in Pediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Abd-Elaziz El-Taweel ◽  
Fatma El-Esawy ◽  
Osama Abdel-Salam
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Tinea Capitis ◽  
Pediatric Patients ◽  
Skin Surface ◽  
Fungal Culture ◽  
Exclamation Mark ◽  
Laboratory Investigations ◽  
Vellus Hairs ◽  
Clinical Dermatology

Background. Diagnosis of patchy hair loss in pediatric patients is often a matter of considerable debate among dermatologists. Trichoscopy is a rapid and noninvasive tool to detect more details of patchy hair loss. Like clinical dermatology, trichoscopy works parallel to the skin surface and perpendicular to the histological plane; like the histopathology, it thus allows the viewing of structures not discovered by the naked eye.Objective. Aiming to compare the different trichoscopic features of tinea capitis and alopecia areata in pediatric patients.Patients and Methods. This study included 40 patients, 20 patients with tinea capitis and 20 patients with alopecia areata. They were exposed toclinical examination, laboratory investigations (10% KOH and fungal culture), and trichoscope examination.Results. Our obtained results reported that, in tinea capitis patients, comma shaped hairs, corkscrew hairs, and zigzag shaped hairs are the diagnostic trichoscopic features of tinea capitis. While in alopecia areata patients, the most trichoscopic specific features were yellow dots, exclamation mark, and short vellus hairs.Conclusion. Trichoscopy can be used as a noninvasive tool for rapid diagnosis of tinea capitis and alopecia areata in pediatric patients.

scholarly journals AB0713 PERIODONTAL DISEASES AND ITS ASSOCIATION WITH ANKYLOSING SPONDYLITIS/SPA: A SYSTEMATIC REVIEW

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1652.1-1652
Author(s):  
A. Pandey ◽  
V. Ravindran ◽  
M. Pandey ◽  
R. Rajak ◽  
V. Pandey
Keyword(s):  
Systematic Review ◽  
Ankylosing Spondylitis ◽  
Connective Tissue ◽  
Inflammatory Response ◽  
Periodontal Disease ◽  
Close Association ◽  
Case Control ◽  
Clinical Attachment Loss ◽  
Tnf Α ◽  
Host Inflammatory Response

Background:A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Objectives:The aim of this systematic review was to appraise the available literature exploring the relationship between AS and periodontal disease.Methods:We searched Medline & Embase databases (from their inception till October 2019) using appropriate combinations of following search items with limits ‘(English, Human)’; Ankylosing spondylitis, spondyloarthritis, spondyloarthropathies, spondyloarthritides, spinal disease, musculoskeletal disease, Rheumatic disease AND periodontitis, periodontal disease, periodontoses, parodontoses, chronic periodontitis, gum disease, gingivitis, oral health, dental health, plaque index, bleeding on probing, probing pocket depth, clinical attachment loss. This search was supplemented by the manual search of bibliographies of articles selected and conferences proceedings of EULAR. Only be reviews, observational study of cross-sectional, cohort or case control type on adult patients with AS were selected. Data was extracted from a predesigned proforma. A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Results:A total number of 984 articles were identified and 12 were selcted for detailed appraisal (Figure 1, PRISMA flow chart). They were all case control studies. The prevalence of periodontitis ranged from 38% to 88% in patients with AS whereas in the control group from 26% to 71 % in controls. Out of 12 studies, two showed significant changes in Plaque Index (PI), two studies showed altered Pocket Probing Depth (PPD), three showed significant increased in Clinical Attachment Loss (CAL) and increased Bleeding On Probing (BOP) was seen in 2 studies. In 7 studies, periodontitis was seen in a significant number of patients with AS (P<0.05). All studies reported that the prevalence of periodontal disease in AS patients was higher as compared to non-AS patients.Conclusion:Our systematic review found an association between AS and periodontal disease. Patients with AS show higher prevalence of periodontitis and a poor oral hygiene as compared to healthy controls. At practice level, this systematic review underscores the need for a collaboration between dentists and rheumatologist.Disclosure of Interests:None declared

Hair Growth in a Patient with Alopecia Areata on Tocilizumab

2021 ◽  
pp. 1-5
Author(s):  
Chloe J. Walker ◽  
Kelly E. Flanagan ◽  
James T. Pathoulas ◽  
Isabel Pupo Wiss ◽  
Maryanne M. Senna
Keyword(s):  
Monoclonal Antibody ◽  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Interleukin 6 ◽  
Hair Growth ◽  
Posterior Uveitis ◽  
Case Presentation ◽  
Antibody Targeting ◽  
Growth Changes

<b><i>Introduction:</i></b> Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. <b><i>Case Presentation:</i></b> Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. <b><i>Discussion:</i></b> Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

scholarly journals Gender Differences in Psychosocial Outcomes of Hair Loss Resulting from Childhood Irradiation for Tinea Capitis

2021 ◽  
Vol 18 (15) ◽  
pp. 7825
Author(s):  
Liat Hoffer ◽  
Netta Achdut ◽  
Shifra Shvarts ◽  
Dorit Segal-Engelchin
Keyword(s):  
Gender Differences ◽  
Hair Loss ◽  
Medical Records ◽  
Tinea Capitis ◽  
Psychosocial Outcomes ◽  
Self Esteem ◽  
Psychosocial Needs ◽  
Increased Risk ◽  
Physical Health Problems ◽  
Physical Bullying

Recent studies have linked hair loss due to childhood irradiation for tinea capitis, a fungal infection of the scalp, to adverse psychosocial and health outcomes in women. However, no study to date has examined gender differences in the outcomes of this type of hair loss. The current study aimed to investigate gender differences in health and psychosocial outcomes of hair loss resulting from childhood irradiation for tinea capitis, and to identify the risk factors associated with depression in both men and women. Medical records held at the archives of the Israel National Center for Compensation of Scalp Ringworm Victims were retrospectively reviewed for 217 women and 105 men who received maximum disability compensation due to severe hair loss resulting from irradiation for tinea capitis. We found that women were at increased risk of developing psychosocial symptoms, including depression. Gender emerged as a significant predictor of depression, distinct from other predictors, such as marital status, age at radiation, exposure to verbal and physical bullying, low self-esteem, social anxiety, and physical health problems. Thus, the psychosocial needs of patients, particularly female patients, who were irradiated for tinea capitis during childhood need to be taken into account by the healthcare professionals treating them.

PPE11 of Mycobacterium tuberculosis can alter host inflammatory response and trigger cell death

2019 ◽  
Vol 126 ◽  
pp. 45-55 ◽  
Author(s):  
Xuan Peng ◽  
Tao Luo ◽  
Xiaoqian Zhai ◽  
Chunxi Zhang ◽  
Jing Suo ◽  
...  
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Inflammatory Response ◽  
Trigger Cell Death ◽  
Host Inflammatory Response

scholarly journals “‘You lose your hair, what’s the big deal?’ I was so embarrassed, I was so self-conscious, I was so depressed:” a qualitative interview study to understand the psychosocial burden of alopecia areata

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Natalie V. J. Aldhouse ◽  
Helen Kitchen ◽  
Sarah Knight ◽  
Jake Macey ◽  
Fabio P. Nunes ◽  
...  
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Disease Recurrence ◽  
Structured Interview ◽  
Emotional Impact ◽  
Psychosocial Effects ◽  
Psychosocial Burden ◽  
Qualitative Interview Study ◽  
Interview Guide ◽  
Expert Clinician

Abstract Background Alopecia areata (AA) is characterized by hair loss that can affect the scalp and body. This study describes the psychosocial burden of AA. Methods Participants diagnosed with AA who had experienced ≥50% scalp hair loss according to the Severity of Alopecia Tool (SALT) were identified by clinicians. A semi-structured interview guide, developed with expert clinician input, included open-ended questions to explore patients’ experiences of living with AA. Data were thematically analyzed to identify concepts and relationships. Results Participants (n = 45, 58% female, mean age 33.3 years [range 15–72], mean SALT 67.2 [range 0–100]) described the AA diagnosis as “devastating”. Both males and females reported emotional and psychological impacts of AA including feeling sad/depressed (n = 21), embarrassed/ashamed (n = 10) and angry/frustrated (n = 3). Patients felt helpless (n = 5) due to the unpredictability of disease recurrence, and anxious (n = 19) about judgement from others. Many patients avoided social situations (n = 18), which impaired relationships and increased isolation. Coping strategies included concealment of hair loss through wigs or make-up, although fear of the displacement of these coverings also caused anxiety and the avoidance of activities that could result in scalp exposure (n = 22). Some patients became more accepting of AA over time, which lessened the emotional impact, though efficacious treatment was still desired. A conceptual framework was developed, and a conceptual model was created to depict the relationship between the physical signs/symptoms and the associated psychosocial effects of AA. Conclusion AA impairs patients’ emotional and psychological wellbeing, relationships and lifestyles. Greater disease awareness and effective treatments are needed.

scholarly journals COVID-19 Pandemic Impact on Severe Alopecia Areata Patients

2021 ◽  
pp. 1-5
Author(s):  
Mehdi Gheisari ◽  
Khatere Zahedi ◽  
Zohreh Tehranchinia ◽  
Hamideh Moravvej ◽  
Fahimeh Abdollahimajd ◽  
...  
Keyword(s):  
Dose Reduction ◽  
Chronic Stress ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Systemic Therapy ◽  
Demographic Data ◽  
Severe Infection ◽  
Drug Dose ◽  
The Other ◽  
Protective Measures

<b><i>Introduction:</i></b> The pandemic of COVID-19 has several implications for patients with chronic stress-sensitive diseases such as alopecia areata (AA). On the other hand, the vulnerability of AA patients using immunosuppressives to a more severe infection is in the shadow of ambiguity. This teledermatology study aimed to evaluate the course and outcome of AA in patients during this challenging period. <b><i>Methods:</i></b> Patients with AA who had previously received systemic therapy included in this study. Information about demographic data, AA history, characteristics, and treatments, hair loss progression, Corona Disease Anxiety Scale (CDAS), adherence to protective measures against the COVID-19, possible infection, and its features obtained via a telephone call. <b><i>Results:</i></b> A total of 57 patients participated. The majority (84.2%) of the participants had mild anxiety assessed by CDAS. Two patients (3.5%) had got infected with COVID-19. Twenty-one (36.8%) participants experienced hair loss progression. Hair loss progression correlated with drug dose reduction (OR: 46.09, 95% CI 5.48–387.14, <i>p</i> &#x3c; 0.001) although it did not influence by the level of anxiety evaluated by the CDAS (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> The anxiety perceived by severe AA patients about COVID-19 is mild; however, many experience hair loss progressions owing to their drug dose reduction.

scholarly journals Coating Polyurethane with Palmitoleic Acid and Bovine Serum Albumin to Prevent the Host Response to Foreign Materials

2020 ◽  
Vol 16 (4) ◽  
pp. 5-13 ◽  
Author(s):  
Sheherbano Hussain ◽  
Zoha Babar ◽  
Jimmy Hadid ◽  
Jacqueline McLaughlin
Keyword(s):  
Bovine Serum Albumin ◽  
Inflammatory Response ◽  
Serum Albumin ◽  
Medical Devices ◽  
Bovine Serum ◽  
Host Response ◽  
Palmitoleic Acid ◽  
Implanted Medical Devices ◽  
Foreign Materials ◽  
Host Inflammatory Response

Macrophages are cells of the immune system that play a pivotal role in the host inflammatory response by attacking and engulfing any foreign molecule not seen as ‘self.’ They also help regulate the host response by releasing a variety of cytokines and growth factors that act as signals to other cells to amplify the host response. However, the host response causes degradation of implanted medical devices composed of polyurethane as well as other synthetic materials which it does not identify as self. Research was undertaken to investigate the potential of coating polyurethane with the self-like molecules palmitoleic acid and albumin to reduce or prevent the body’s host response from damaging implanted medical devices. Using an in vitro THP-1 bioassay, polyurethane films coated with palmitoleic acid and bovine serum albumin showed a reduction in macrophage adherence. The individually coated palmitoleic acid and bovine serum albumin films significantly reduced the number of cells attached to the films with increasing concentration while the films coated with the conjugate of both showed no statistical difference. This suggests the potential role of self-like molecules in reducing the inflammatory response to foreign materials. KEYWORDS: Macrophages; host inflammatory response; THP-1; prosthetics; palmitoleic acid; bovine serum albumin; cytokines; immune system

scholarly journals Pharmaceutico-Analytical study of Karanjadi Taila and its conversion into cream

2020 ◽  
Vol 5 (05) ◽  
pp. 245-249
Author(s):  
Sachin S. Sheth ◽  
Gangaprasad R. Asore ◽  
Kiran Sudhakar Darade
Keyword(s):  
Present Article ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Analytical Study ◽  
Chief Complaint ◽  
Point Of View ◽  
Special Importance ◽  
Analytical Results

Karanjadi Taila is medicated oil used in Ayurveda for Indralupta (Alopecia). Indralupta comes under Kshudra Roga which is characterized by loss of hair it can be correlated with Alopecia areata which is having chief complaint of hair loss on body especially on scalp. The aim of the present study is to do physic-chemical standards for the above Taila and its conversion into Karanjadi Taila cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Tailas or cream. In present article, we are trying to study analytical results of Karanjadi Taila w.s.r. to Karanjadi Taila cream.

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