scholarly journals Dramatic invasion of the orbit by periocular cutaneous squamous cell carcinoma

2020 ◽  
Vol 11 (e) ◽  
pp. e130.1-e130.3
Author(s):  
Aida Oulehri ◽  
Sara Elloudi ◽  
Hanane Baybay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Skin Tumors ◽  
Malignant Neoplasms ◽  
Complete Destruction ◽  
Malignant Skin Tumors ◽  
Malignant Skin ◽  
Orbital Region

The periocular skin is susceptible to numerous benign and malignant neoplasms. Malignant skin tumors of the periocular area are very particular; they can present differently, are rapidly aggressive and pose a real therapeutic challenge. Aggressive forms occur mostly in immunocompromised individuals. A complete destruction of the orbit is rare and the initial seat is most often the eyelid. We report the case of an immunocompetent 70-year-old patient with destruction of the entire orbital region including the eyeball secondary to the extension of squamous cell carcinoma of the internal canthus.

scholarly journals Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

2008 ◽  
Vol 20 (6) ◽  
pp. 766-773 ◽  
Author(s):  
Francesco Sassi ◽  
Giuseppe Sarli ◽  
Barbara Brunetti ◽  
Federico Morandi ◽  
Cinzia Benazzi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mammary Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mammary Tumors ◽  
Squamous Cell Carcinomas ◽  
Sweat Glands ◽  
Malignant Skin Tumors ◽  
Malignant Skin

Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anticytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.

scholarly journals Deceiving & deceptive growth in the ear canal in an elderly female

2021 ◽  
Vol 13 (4) ◽  
pp. 74-77
Author(s):  
Sphoorthi Basavannaiah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
External Auditory Canal ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Malignant Neoplasms ◽  
Ear Canal ◽  
Elderly Female ◽  
Primary Neoplasms

Malignant neoplasms of the external auditory canal, middle and inner ear are rare. Squamous cell carcinoma (SCC) is the most common neoplasm to occur in this region. As such primary neoplasms of the external auditory canal and temporal bone are uncommon, as these structures more frequently are involved by the cutaneous squamous cell carcinoma (cSCC) of pinna or metastatic cSCC involving parotid gland or post auricular lymph nodes.

MicroRNA-200c Prevents Progress of Cutaneous Squamous Cell Carcinoma by Targeting Tyrosine-Protein Kinase Fyn (FYN)

2021 ◽  
Vol 11 (5) ◽  
pp. 886-895
Author(s):  
Jie Yang ◽  
Jianji Wan ◽  
Xiuqin Dong ◽  
Liehua Deng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cellular Growth ◽  
Skin Tumor ◽  
Promoting Effect ◽  
Mesenchymal Transition ◽  
Malignant Skin

Cutaneous squamous cell carcinoma (cSCC), a malignant skin tumor, begins in the epidermis and the keratinocytes of the skin appendages. However, the cause remains unclear. MicroRNA-200c (miR-200c), a key modulator of epithelial-to-mesenchymal transition (EMT), has been reported to act as an anticancer gene in a variety of cancers. However, its role and partial mechanism in cSCC remain undetermined. The results of this study showed depleted levels of miR-200c in cSCC tissues. Its suppressive effects on cell proliferation, and motility, as well as its apoptosis-promoting effect, were observed in the A-431 cells. Additionally, immunofluorescence and qRT-PCR assays revealed that FYN acted as a direct target of miR-200c, and FYN knockdown exerted had similar impact as that of miR-200c overexpression, including increased cellular apoptosis and decreased cellular growth. These results emphasized the onco-suppressive nature of miR-200c, which was evident based on its interaction with FYN in cSCC. This finding could have potential benefits in developing cSCC therapy.

A Case of Anti-TIF1-γ Antibody-positive Dermatomyositis with Cutaneous Squamous Cell Carcinoma

2018 ◽  
Vol 80 (4) ◽  
pp. 331-335
Author(s):  
Reika FUKUCHI ◽  
Sayaka KUWATSUKA ◽  
Yukie SATO ◽  
Yutaka KUWATSUKA ◽  
Atsushi UTANI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

Multidisciplinary Expert-Driven Consensus on the Evolving Treatment of Patients with Advanced Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 3 ◽  
pp. S50
Author(s):  
Michael R Migden ◽  
Todd E Schlesinger ◽  
Chrysalyne D Schmults ◽  
Scott M Dinehart ◽  
Robert L Ferris ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

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