scholarly journals Investigating the role of Interleukin-33 and Soluble ST2 in pediatric atopic dermatitis

2020 ◽  
Vol 11 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Ilona Paulauskaite ◽  
Audrone Eidukaite ◽  
Odilija Rudzevičiene
Keyword(s):  
Atopic Dermatitis ◽  
Soluble St2 ◽  
Interleukin 33

scholarly journals The role of interleukin-1ß and interleukin-33 in atopic dermatitis

2013 ◽  
Vol 4 (1) ◽  
pp. 111-114 ◽  
Author(s):  
Rania M. Abdel Hay ◽  
Noha F. Ibrahim ◽  
Dina Metwally ◽  
Laila A. Rashed
Keyword(s):  
Atopic Dermatitis ◽  
Interleukin 33

scholarly journals The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

2021 ◽  
Vol 22 (13) ◽  
pp. 7227
Author(s):  
Lai-San Wong ◽  
Yu-Ta Yen ◽  
Chih-Hung Lee
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immune Responses ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Targeted Therapies ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Inflammatory Molecules

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

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