scholarly journals Odhiambo (Christopher Joseph), Theatre for Development in Kenya. In Search of an Effective Procedure and Methodology. Bayreuth : Pia Thelmann & Eckhard Breitinger / Bayreuth University Press, coll. Bayreuth African Studies n°86, 2008, 201 p., bibl., index, ill. phot. NB – ISBN 978-3-939661-07-8

2008 ◽  
pp. 118
Author(s):  
Maëline Le Lay
Keyword(s):  
Effective Procedure ◽  
African Studies ◽  
Theatre For Development

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

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