scholarly journals Correlation of Serum Ferritin Levels with Liver Function Tests and Anthropometric Measurements in Transfusion Dependent Beta-Thalassemia Major Children: A Cross Sectional Study

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Harish G V ◽  
Sayyed John Pasha
Keyword(s):  
Liver Function ◽  
Serum Ferritin ◽  
Liver Function Tests ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major

scholarly journals A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

2008 ◽  
Vol 28 (5) ◽  
pp. 361 ◽  
Author(s):  
Farzad Najafipour ◽  
Akbar Aliasgarzadeh ◽  
Naser Aghamohamadzadeh ◽  
Amir Bahrami ◽  
Majid Mobasri ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Endocrine Complications

Prevalence of metabolic syndrome in beta thalassemia major adolescents in southern Iran: a cross-sectional study

2018 ◽  
Vol 39 (3) ◽  
pp. 444-450
Author(s):  
Forough Saki ◽  
Rezieh Bahadori ◽  
Navid Moradi Kashkooli ◽  
Amin Jazayeri ◽  
Negin Ghahremani ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Southern Iran

scholarly journals A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

2008 ◽  
Vol 28 (5) ◽  
pp. 361-366 ◽  
Author(s):  
Farzad Najafipour ◽  
Akbar Aliasgarzadeh ◽  
Naser Aghamohamadzadeh ◽  
Amir Bahrami ◽  
Majid Mobasri ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Endocrine Complications

scholarly journals Serum IGF-1 and short stature in adolescents with beta-thalassemia major

2018 ◽  
Vol 58 (4) ◽  
pp. 151-8 ◽  
Author(s):  
Monalisa Elizabeth ◽  
Eddy Fadlyana ◽  
Lelani Reniarti ◽  
Faisal Faisal ◽  
Hadyana Sukandar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Short Stature ◽  
Family Income ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Growth Chart ◽  
Chi Square ◽  
Cross Sectional ◽  
Beta Thalassemia Major

Background The  prevalence  of  short  stature  in  thalassemia  patients ranges from 39.3 to 65%.  The  cause  of short stature is complex  and  still up for debate.  In  Indonesia, data on the  prevalence  and risk  factors  of  short  stature  in  adolescents  with  thalassemia  have been limited. Objective To assess for the prevalence and risk factors of short stature in adolescents with beta-thalassemia major. Methods This cross-sectional study was done from February to March 2017 at the Thalassemia Clinic at Dr. Hasan Sadikin General Hospital, Bandung. The baseline characteristics data of 80 adolescents with thalassemia aged 10-14 years were recorded. Short stature was assessed by height-for-age, (Z-score <-2SD) based on the 2007 WHO Reference Growth Chart. Mid-upper arm circumference was scored according to age and sex and serum IGF-1 was measured by ELISA method. Data analyses used were Chi-square, Fisher’s, and Mann-Whitney tests. Logistic regression model was used to further analyze for risk factors of short stature. Results Subjects were 40 males and 40 females, 81.2% of whom had short stature. The mean serum IGF-1 level was 32.2 (SD 26.38) ng/mL. The IGF-1 cut-off point by ROC curve was £38.51 ng/mL, with sensitivity of 64.4% and specificity of 86.7%. The risk factors of short stature were IGF-1 level £38.51 ng/mL (PR 40.66; 95%CI 4.37 to 377.58; P<0.001) and low family income (PR 19.76; 95%CI: 1.152 to 256.08; P=0.022). Conclusion IGF-1 level may be useful as a predictor of short stature in adolescent beta-thalassemia major patients.

scholarly journals Renal damages in patients with major β-thalassemia

2019 ◽  
Vol 9 (1) ◽  
pp. e02-e02
Author(s):  
Malihe Najafpour ◽  
Majid Farshdousti-Hagh ◽  
Ali Akbar Movasagpoor-Akbari ◽  
Abbas-Ali Hosein-Pour Feyzi ◽  
Majid Malaki
Keyword(s):  
Renal Function ◽  
Renal Dysfunction ◽  
Urine Analysis ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Control

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

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