A Randomized Controlled Facility Based Trial to Assess the Impact of Indigenously Prepared Ready to Use Therapeutic Food (RUTF) for Children with Severe Acute Malnutrition in India

2016 ◽  
Vol 13 (4) ◽  
Author(s):  
Alka Jadhav ◽  
Bina Dias ◽  
Narendra Shah ◽  
Lavina Fernandes ◽  
Sneha Fernandes ◽  
...  
Keyword(s):  
Severe Acute Malnutrition ◽  
Acute Malnutrition ◽  
Randomized Controlled ◽  
The Impact ◽  
Therapeutic Food

scholarly journals Determinants of the Global Prices of Ready-to-Use Therapeutic Foods

2018 ◽  
Vol 39 (3) ◽  
pp. 435-448 ◽  
Author(s):  
Jakub Kakietek
Keyword(s):  
Price Competition ◽  
Severe Acute Malnutrition ◽  
Estimating Equation ◽  
Cost Driver ◽  
Acute Malnutrition ◽  
Generalized Estimating Equation ◽  
Market Fragmentation ◽  
Outpatient Settings ◽  
The Impact ◽  
Therapeutic Food

Background: A therapy based on ready-to-use therapeutic food (RUTF) in outpatient settings is considered the gold standard in the treatment of severe acute malnutrition in children younger than 5 years. The price of RUTF is the key cost driver of the therapy. However, no studies to date have systematically examined the determinants of RUTF prices. Objective: This article presents the first analysis of factors associated with the prices of RUTF, focusing on the impact of competition and tendering. Methods: This article examines data on the prices of RUTF purchased by UNICEF Supply Division from 2006 through 2015 (90% of RUTF purchased globally). To assess the association between price, competition, and tender introduction, controlling for potential confounding factors, regression analysis using a generalized estimating equation was used. Results: Competition, measured as the number of suppliers, was negatively associated with RUTF price. On the other hand, no statistically significant association was found between RUTF price tendering. Quantities sold were also significantly associated with RUTF prices. Conclusions: Significant price reductions have been achieved by increasing competition in the RUTF market. In contrast, introduction of tendering did not result in decreases in prices. Tendering is an effective price-lowering mechanism because it awards the bidder(s) with the lowest price with market exclusivity. However, the current tender system promotes market fragmentation and reduces the incentives for price reductions. Further reduction in RUTF prices can likely be achieved by modifying the current tendering procedures and putting a greater emphasis on price competition.

Treatment of severe acute malnutrition with oat or standard ready-to-use therapeutic food: a triple-blind, randomised controlled clinical trial

Gut ◽  
2020 ◽  
Vol 69 (12) ◽  
pp. 2143-2149 ◽  
Author(s):  
David Taylor Hendrixson ◽  
Claire Godbout ◽  
Alyssa Los ◽  
Meghan Callaghan-Gillespie ◽  
Melody Mui ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Vegetable Oil ◽  
Severe Acute Malnutrition ◽  
Milk Powder ◽  
Acute Malnutrition ◽  
Growth Time ◽  
Controlled Clinical Trial ◽  
Hydrogenated Vegetable Oil ◽  
Therapeutic Food ◽  
Time To Graduation

ObjectiveWe hypothesised that an alternative RUTF (ready-to-use therapeutic food) made with oats (oat-RUTF) would be non-inferior to standard RUTF (s-RUTF).DesignThis was a randomised, triple-blind, controlled, clinical non-inferiority trial comparing oat-RUTF to s-RUTF in rural Sierra Leone. Children aged 6–59 months with severe acute malnutrition (SAM) were randomised to oat-RUTF or s-RUTF. s-RUTF was composed of milk powder, sugar, peanut paste and vegetable oil, with a hydrogenated vegetable oil additive. Oat-RUTF contained oats and no hydrogenated vegetable oil additives. The primary outcome was graduation, an increase in anthropometric measurements such that the child was not acutely malnourished. Secondary outcomes were rates of growth, time to graduation and presence of adverse events. Intention to treat analyses was used.ResultsOf the 1406 children were enrolled, graduation was attained in 404/721 (56%) children receiving oat-RUTF and 311/685 (45%) receiving s-RUTF (difference 10.6%, 95% CI 5.4% to 15.8%). Death, hospitalisation or remaining with SAM was seen in 87/721 (12%) receiving oat-RUTF and in 125/685 (18%) receiving s-RUTF (difference 6.2%, 95% CI 2.3 to 10.0, p=0.001). Time to graduation was less for children receiving oat RUTF; 3.9±1.8 versus 4.5±1.8 visits, respectively (p<0.001). Rates of weight in the oat-RUTF group were greater than in the s-RUTF group; 3.4±2.7 versus 2.5±2.3 g/kg/d, p<0.001.ConclusionOat-RUTF is superior to s-RUTF in the treatment of SAM in Sierra Leone. We speculate that might be because of beneficial bioactive components or the absence of hydrogenated vegetable oil in oat-RUTF.Trial registration numberNCT03407326.

Indigenously Prepared Ready-to-use Therapeutic Food (RUTF) in Children with Severe Acute Malnutrition

2019 ◽  
Vol 56 (4) ◽  
pp. 287-293
Author(s):  
Alka Rajendra Jadhav ◽  
Prachi Karnik ◽  
Lavina Fernandes ◽  
Sneha Fernandes ◽  
Narendra Shah ◽  
...  
Keyword(s):  
Severe Acute Malnutrition ◽  
Acute Malnutrition ◽  
Therapeutic Food
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