Honoring Deceased Donors with a Unique Family-Designed Statement Followed by a Moment of Silence: Effect on Donation Outcomes

2013 ◽  
Vol 23 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Nikole Neidlinger ◽  
Brandy Gleason ◽  
Jing Cheng
Keyword(s):  
Silence Effect ◽  
Deceased Donors

Rate, Factors, and Outcome of Delayed Graft Function After Kidney Transplantation of Deceased Donors

2021 ◽  
Author(s):  
Laura Jahn ◽  
Christiane Rüster ◽  
Mandy Schlosser ◽  
Yvonne Winkler ◽  
Susan Foller ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Deceased Donors

Clinical Impacts and Outcomes With Possible Donor-Derived Infection in Infected Donor Liver Transplantation: A Single-Center Retrospective Study in China

2020 ◽  
Vol 221 (Supplement_2) ◽  
pp. S164-S173
Author(s):  
Li Tong ◽  
Xiao-Guang Hu ◽  
Fa Huang ◽  
Shun-Wei Huang ◽  
Li-Fen Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antibiotic Sensitivity ◽  
Resistant Bacteria ◽  
Single Center ◽  
Sensitivity Testing ◽  
Donor Liver Transplantation ◽  
Infected Donor ◽  
Recipient Group ◽  
Deceased Donors ◽  
Liver Recipient

Abstract Background Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in recipients, and evaluated the etiologic agents’ characteristics and cases outcomes. Methods A single-center observational study was performed from January 2015 to March 2017 to retrospectively collect data from deceased-donors diagnosed with infection. Clinical data were recorded for each culture-positive donor and the matched liver recipient. The microorganisms were isolated and identified, and antibiotic sensitivity testing was performed. The pathogens distribution and incidence of possible donor-derived infection (P-DDI) events were analyzed and evaluated. Results Information from 211 donors was collected. Of these, 82 donors were infected and classified as the donation after brain death category. Overall, 149 and 138 pathogens were isolated from 82 infected donors and 82 matched liver recipients, respectively. Gram-positive bacteria, Gram-negative bacteria, and fungi accounted for 42.3% (63 of 149), 46.3% (69 of 149), and 11.4% (17 of 149) of pathogens in infected donors. The incidence of multidrug-resistant bacteria was high and Acinetobacter baumannii was the most concerning species. Infections occurred within the first 2 weeks after liver transplantation with an organ from an infected donor. Compared with the noninfection recipient group, the infection recipient group experienced a longer mechanical ventilation time (P = .004) and intensive care unit stay (P = .003), a higher incidence of renal dysfunction (P = .026) and renal replacement therapy (P = .001), and higher hospital mortality (P = .015). Possible donor-derived infection was observed in 14.6% of cases. Recipients with acute-on-chronic liver failure were more prone to have P-DDI than recipients with other diseases (P = .007; odds ratio = 0.114; 95% confidence interval, .025–.529). Conclusions When a liver recipient receives a graft from an infected deceased-donor, the postoperative incidence of infection is high and the infection interval is short. In addition, when a possible donor-derived, drug-resistant bacterial infection occurs, recipients may have serious complications and poor outcomes.

Lens and Peripheral Retinal Relationships During Vitrectomy: Comparison of 23-, 25-, and 27-Gauge Vitrectomy and Curved Endolaser Probes

2020 ◽  
pp. 247412642097197
Author(s):  
Jacob S. Duker ◽  
Michael J. Venincasa ◽  
Pedro F. Monsalve ◽  
Armando L. Garcia ◽  
Sander R. Dubovy ◽  
...  
Keyword(s):  
Insertion Site ◽  
Crystalline Lens ◽  
Peripheral Retina ◽  
Small Gauge ◽  
The Mean ◽  
Deceased Donors ◽  
23 Gauge ◽  
Considerable Range ◽  
Safe Access ◽  
Phakic Eyes

Purpose: This work aims to compare spatial relationships between the crystalline lens and vitrectomy instruments of different gauges. Methods: Eight phakic eyes recovered from deceased donors were used after fixation. Valved trocars (27-gauge, 25-gauge, and 23-gauge) were sequentially placed in the superotemporal quadrant 4 mm posterior to the limbus in each eye. Intraocular relationships of vitrectomy and curved endolaser probes were measured for each gauge. Results: There were no significant differences in maneuverability between instruments of different gauges. The mean distance from instrument to lens at the geometric center of the globe was 5.5 mm. Vitrectomy probes of all gauges could access the peripheral retina on both sides of the sclerotomy in the 3 to 4 o’clock position adjacent to the sclerotomy without touching the lens. The instruments could be advanced without lens touch to contact the retina within at least 2 mm of the ora serrata 180° away from the insertion site. Conclusions: Vitrectomy and curved endolaser probes achieved similar maneuverability relative to the lens regardless of gauge. This study confirms that small-gauge vitrectomy instruments have a considerable range of safe access to the peripheral retina in phakic eyes from a single sclerotomy.

Kidney transplantation in the extremely elderly from extremely aged deceased donors: a kidney for each age

2020 ◽  
Vol 35 (4) ◽  
pp. 687-696
Author(s):  
Jimena Cabrera ◽  
Mario Fernández-Ruiz ◽  
Hernando Trujillo ◽  
Esther González ◽  
María Molina ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Cox Regression ◽  
Patient Survival ◽  
Incidence Rates ◽  
Allocation Policy ◽  
Recipient Age ◽  
Deceased Donors ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Advances in life expectancy have led to an increase in the number of elderly people with end-stage renal disease (ESRD). Scarce information is available on the outcomes of kidney transplantation (KT) in extremely elderly patients based on an allocation policy prioritizing donor–recipient age matching. Methods We included recipients ≥75 years that underwent KT from similarly aged deceased donors at our institution between 2002 and 2015. Determinants of death-censored graft and patient survival were assessed by Cox regression. Results We included 138 recipients with a median follow-up of 38.8 months. Median (interquartile range) age of recipients and donors was 77.5 (76.3–79.7) and 77.0 years (74.7–79.0), with 22.5% of donors ≥80 years. Primary graft non-function occurred in 8.0% (11/138) of patients. Cumulative incidence rates for post-transplant infection and biopsy-proven acute rejection (BPAR) were 70.3% (97/138) and 15.2% (21/138), respectively. One- and 5-year patient survival were 82.1 and 60.1%, respectively, whereas the corresponding rates for death-censored graft survival were 95.6 and 93.1%. Infection was the leading cause of death (46.0% of fatal cases). The occurrence of BPAR was associated with lower 1-year patient survival [hazard ratio (HR) = 4.21, 95% confidence interval (CI) 1.64–10.82; P = 0.003]. Diabetic nephropathy was the only factor predicting 5-year death-censored graft survival (HR = 4.82, 95% CI 1.08–21.56; P = 0.040). Conclusions ESRD patients ≥75 years can access KT and remain dialysis free for their remaining lifespan by using grafts from extremely aged deceased donors, yielding encouraging results in terms of recipient and graft survival.

Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation

2012 ◽  
Vol 44 (4) ◽  
pp. 1107-1111 ◽  
Author(s):  
Shivam Joshi ◽  
Rajinikanth Ayyathurai ◽  
Ahmed Eldefrawy ◽  
Jason Aminsharifi ◽  
Obi Ekwenna ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Kidney Donation ◽  
Deceased Donors

Deceased Donors Renal Transplantation from Older Donors to Increase the Donor Pool

2012 ◽  
Vol 94 (10S) ◽  
pp. 853
Author(s):  
V. B. Kute ◽  
H. L. Trivedi ◽  
A. V. Vanikar ◽  
P. R. Shah ◽  
M. R. Gumber ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Donor Pool ◽  
Deceased Donors

scholarly journals Enduring Cell Lines: Parents’ Experiences of Postmortem Tumor Banking in Childhood Cancer

2021 ◽  
pp. 107484072110014
Author(s):  
Nancy J. Moules ◽  
Catherine M. Laing ◽  
Wendy Pelletier ◽  
Gregory M. T. Guilcher ◽  
Jennifer A. Chan
Keyword(s):  
Childhood Cancer ◽  
Pediatric Oncology ◽  
Common Factors ◽  
Living Cells ◽  
The Past ◽  
The Family ◽  
Deceased Donors ◽  
Cure Rates ◽  
The Impact ◽  
Parents Experiences

While cure rates in pediatric oncology have improved over the past 30 years, childhood cancer remains the second leading cause of death in children aged 1 to 14. Developing therapies often require using cancerous tissues, which may come from deceased donors. Tumor banks collect, store, and distribute these donated samples. While tumor banking is more common, factors that contribute to parents’ decision and the impact of it on the family are not well understood. The purpose of this hermeneutic study was to understand the meaning and impact of tumor banking for parents of children who have died from cancer. Findings suggest that parents donating their child’s tumors unexpectedly found a sense of meaning in their loss. They also found a legacy of their child’s life; the living cells in some ways assisted the parents with grief. Aspects of this sensitive conversation and decision are discussed from the perspective of the parents’ experiences.

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