Serum E-cadherin and Hepatocyte Growth Factor in Acute Pancreatitis: Exploring Time Course, and Severity Assessment

10.7178/ig.23 ◽  
2013 ◽  
Vol 2 (1) ◽  
pp. 57 ◽  
Author(s):  
Raffaele Pezzilli ◽  
Keyword(s):  
Acute Pancreatitis ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Time Course ◽  
Severity Assessment ◽  
Hepatocyte Growth ◽  
E Cadherin

scholarly journals HGF Converts ErbB2/Neu Epithelial Morphogenesis to Cell Invasion

2005 ◽  
Vol 16 (2) ◽  
pp. 550-561 ◽  
Author(s):  
Hanane Khoury ◽  
Monica A. Naujokas ◽  
Dongmei Zuo ◽  
Veena Sangwan ◽  
Melanie M. Frigault ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Invasion ◽  
Single Cells ◽  
Epithelial Morphogenesis ◽  
Cell Junctions ◽  
Junction Protein ◽  
Hepatocyte Growth ◽  
E Cadherin ◽  
Cell Cell

Activation of the hepatocyte growth factor receptor Met induces a morphogenic response and stimulates the formation of branching tubules by Madin-Darby canine kidney (MDCK) epithelial cells in three-dimensional cultures. A constitutively activated ErbB2/Neu receptor, NeuNT, promotes a similar invasive morphogenic program in MDCK cells. Because both receptors are expressed in breast epithelia, are associated with poor prognosis, and hepatocyte growth factor (HGF) is expressed in stroma, we examined the consequence of cooperation between these signals. We show that HGF disrupts NeuNT-induced epithelial morphogenesis, stimulating the breakdown of cell-cell junctions, dispersal, and invasion of single cells. This correlates with a decrease in junctional proteins claudin-1 and E-cadherin, in addition to the internalization of the tight junction protein ZO-1. HGF-induced invasion of NT-expressing cells is abrogated by pretreatment with a pharmacological inhibitor of the mitogen-activated protein kinase kinase (MEK) pathway, which restores E-cadherin and ZO-1 at cell-cell junctions, establishing the involvement of MEK-dependent pathways in this process. These results demonstrate that physiological signals downstream from the HGF/Met receptor synergize with ErbB2/Neu to enhance the malignant phenotype, promoting the breakdown of cell-cell junctions and enhanced cell invasion. This is particularly important for cancers where ErbB2/Neu is overexpressed and HGF is a physiological growth factor found in the stroma.

Hepatocyte growth factor induces a protective effect in cerulein-induced acute pancreatitis in mice

Pancreatology ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. S2
Author(s):  
M. Palestino-Dominguez ◽  
L.E. Gomez-Quiroz ◽  
J. Marquardt ◽  
M. Peláez-Luna ◽  
R.U. Miranda ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Protective Effect ◽  
Hepatocyte Growth

Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells

Urology ◽  
2001 ◽  
Vol 58 (6) ◽  
pp. 1064-1069 ◽  
Author(s):  
Hidenobu Miura ◽  
Kenji Nishimura ◽  
Akira Tsujimura ◽  
Kiyomi Matsumiya ◽  
Kunio Matsumoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Hepatocyte Growth ◽  
E Cadherin ◽  
Cell Cell

Hepatocyte Growth Factor Increases in Injured Organs and Functions as an Organotrophic Factor in Rats with Experimental Acute Pancreatitis

Pancreas ◽  
2000 ◽  
Vol 20 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Takashi Ueda ◽  
Yoshifumi Takeyama ◽  
Yuichi Hori ◽  
Masayuki Shinkai ◽  
Kozo Takase ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Experimental Acute Pancreatitis ◽  
Hepatocyte Growth

Recombinant human hepatocyte growth factor provides protective effects in cerulein‐induced acute pancreatitis in mice

2018 ◽  
Vol 233 (12) ◽  
pp. 9354-9364 ◽  
Author(s):  
Mayrel Palestino‐Dominguez ◽  
Mario Pelaez‐Luna ◽  
Roberto Lazzarini‐Lechuga ◽  
Ignacio Rodriguez‐Ochoa ◽  
Veronica Souza ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Human Hepatocyte ◽  
Protective Effects ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

scholarly journals Modulation of E-Cadherin by Hepatocyte Growth Factor Induces Aggressiveness of Gastric Carcinoma

2005 ◽  
Vol 242 (5) ◽  
pp. 676-683 ◽  
Author(s):  
Sang-Uk Han ◽  
Hwa-Young Lee ◽  
Jae-Ho Lee ◽  
Wook-Hwan Kim ◽  
Hyunja Nam ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gastric Carcinoma ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth ◽  
E Cadherin
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