scholarly journals Parecoxib nel trattamento del dolore post-operatorio: considerazioni farmacoeconomiche

2004 ◽  
Vol 5 (4) ◽  
pp. 227-242
Author(s):  
Federica Mathis ◽  
Lorenzo Pradelli ◽  
Mario Eandi
Keyword(s):  
Safety Profile ◽  
Parenteral Administration ◽  
Effective Management ◽  
Efficacy And Safety ◽  
The Public ◽  
New Drug ◽  
Surgical Pain ◽  
Safety Studies ◽  
Cox 2

Parecoxib sodium is the first selective COX- 2 inhibitor to be available for parenteral administration. This pharmaceutical feature, alongside its favorable efficacy and safety profile, makes the new drug particularly suitable for simple and effective management of post-surgical pain. Aim of this work is to describe the pharmacoeconomical profile of the drug in the Italian setting, focusing on the comparison with parenteral ketorolac, the most widely prescribed treatment for post-surgical pain in Italy. The first part of the article describes the most important pharmacological characteristics of parecoxib and reviews the main efficacy and safety studies that were performed on patients presenting with post-surgical pain. A similar article about parecoxib was published on “Farmeconomia e percorsi terapeutici” 2003; 4(1): 39-50. At that moment, the price to the public wasn’t yet fixed and therefore the pharmacoeconomical analysis was based on estimated price. Moreover, during this year, extra studies were published on the efficacy of parecoxib on patients with post-surgical pain. For these reasons, we intend to present here an updated version of the profile.

scholarly journals Parecoxib nel trattamento del dolore postoperatorio: considerazioni farmacoeconomiche

2003 ◽  
Vol 4 (1) ◽  
pp. 39-50
Author(s):  
Lorenzo Pradelli ◽  
Mario Eandi
Keyword(s):  
Patient Monitoring ◽  
Scientific Evidence ◽  
Drug Acquisition ◽  
Effective Management ◽  
Efficacy And Safety ◽  
Analgesic Action ◽  
Surgical Pain ◽  
Minor Surgery ◽  
Safety Studies

Parecoxib sodium is the first selective COX- 2 inhibitor to be available for parenteral administration. This pharmaceutical feature, alongside its favorable efficacy and safety profile, makes the new drug particularly suitable for simple and effective management of post-surgical pain. The first part of the present article describes the most important pharmacological characteristics of parecoxib and reviews the main efficacy and safety studies that were performed on patients presenting with post-surgical pain. Starting from these clinical data, the second part outlines the pharmacoeconomical profile of the drug in the Italian setting, focusing on the comparison with parenteral ketorolac, the most widely prescribed treatment for post-surgical pain in Italy. The available scientific evidence suggests that the introduction of parecoxib in the arsenal of available options for the management of this kind of patients in Italy may have a positive clinical and economical impact, despite of the higher drug acquisition price. In particular, the better tolerability shown by parecoxib in the comparison with non-selective NSAIDs would permit a reduction in the costs for the prevention and the cure of drugrelated adverse events and reduce the need for patient monitoring. Furthermore, the improved safety and the longer duration of the analgesic action could allow the management of more minor surgery patients in daysurgery units, with great economical advantages for the hospital and the health system and improved quality of life for the patients.

Economic Growth and Defence Spending: An Efficiency Analysis of Romania’s Conscription Suspension

2020 ◽  
Vol 26 (2) ◽  
pp. 44-51
Author(s):  
Alin Teodor Huseraș ◽  
Andrei Ciprian Spînu
Keyword(s):  
Graphical Analysis ◽  
Defense Spending ◽  
National Defense ◽  
Effective Management ◽  
External Funding ◽  
The Public ◽  
Defence Spending ◽  
Key Sectors ◽  
The Military ◽  
Theoretical Issues

AbstractNational defense is one of the key sectors responsible for maintaining national security, being considered at the same time an element of great importance and strict necessity of the public sector. The performance of defense functions and missions are closely linked to the military capabilities of this sector, which in turn depend on the budget for defense spending. This paper deals with some theoretical issues in the economic field of defense, regarding the size of defense spending in GDP and their social effects. It is also trying to carry out an analysis on the efficiency versus inefficiency in the use of defense resources, to finance the two types of recruitment systems, namely: by conscription or voluntary will. In order to be able to achieve the above, graphical analysis methods and calculation dermination method were used. The efficiency of spending public funds depends on both objective factors such as: distribution of a certain share of GDP to a certain area; attracting internal and external funding, as well as subjective factors, like: allocating resources to certain categories of expenses; allocating resources to certain defense programs; effective management of these resources by the competent structures. Therefore, for a program to be considered effective, it must meet the requirements of the collective needs of society, be rationally implemented and be sustainable.

scholarly journals 4CPS-294 Efficacy and safety profile of trifluridine–tipiracil and regorafenib in the treatment of metastatic colorectal cancer

2021 ◽  
Author(s):  
L Cantarelli ◽  
JA Morales Barrios ◽  
F Gutierrez Nicolas ◽  
S Garcia Gil ◽  
B Del Rosario Garcia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Safety Profile ◽  
Efficacy And Safety

Efficacy and safety profile of Sitagliptin, vildagliptin, and metformin in newly diagnosed type 2 diabetic subjects

2021 ◽  
Author(s):  
Sahar Hossam Elhini ◽  
Amal Kmal Hussien ◽  
Ahmed Abd Elsamie Omran ◽  
Asmaa A. Elsayed ◽  
Haitham saeed
Keyword(s):  
Safety Profile ◽  
Newly Diagnosed ◽  
Efficacy And Safety ◽  
Type 2 Diabetic
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