Genome-Wode Association Studies (GWAS) Deliver Big Breakthroughs in Identifying Type 2 Diabetes Susceptibility Genes in the General Population

2009 ◽  
Vol 2 (1) ◽  
pp. 6
Author(s):  
Wei Cui ◽  
◽  
Cuilin Zhang ◽  
Yiqing Song ◽  
◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
General Population ◽  
Association Studies ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility

scholarly journals Replication of Genome-Wide Association Studies of Type 2 Diabetes Susceptibility in Japan

2008 ◽  
Vol 93 (8) ◽  
pp. 3136-3141 ◽  
Author(s):  
Yukio Horikawa ◽  
Kazuaki Miyake ◽  
Kazuki Yasuda ◽  
Mayumi Enya ◽  
Yushi Hirota ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Studies ◽  
Susceptibility Genes ◽  
Large Sample Size ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
Candidate Loci

Abstract Background: In Europeans and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates. Objective and Design: The aim of this study was to replicate in a Japanese population previously identified associations of single nucleotide polymorphisms (SNPs) within 10 candidate loci with type 2 diabetes using a relatively large sample size: 1921 subjects with type 2 diabetes and 1622 normal controls. Results: A total of 15 SNPs were genotyped. Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05–1.27); P = 4.5 × 10−3] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14–1.40); P = 1.4 × 10−5] and rs7923837 [OR = 1.27 (95% CI 1.13–1.43); P = 1.0 × 10−4] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15–1.40); P = 1.9 × 10−6] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11–1.36); P = 8.1 × 10−5] and rs1470579 [OR = 1.18 (95% CI 1.07–1.31); P = 8.3 × 10−4] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17–1.41); P = 4.5 × 10−7] and rs7756992 [OR = 1.27 (95% CI 1.15–1.40); P = 9.8 × 10−7] in CDKAL1. The first and second strongest associations were found at variants in CDKAL1 and CDKN2B, both of which are involved in the regenerative capacity of pancreatic β-cells. Conclusion: Some of these variants represent common type 2 diabetes-susceptibility genes in both Japanese and Europeans.

scholarly journals Genomewide Search for Type 2 Diabetes Susceptibility Genes in Four American Populations

2000 ◽  
Vol 66 (6) ◽  
pp. 1871-1881 ◽  
Author(s):  
Margaret Gelder Ehm ◽  
Maha C. Karnoub ◽  
Hakan Sakul ◽  
Kirby Gottschalk ◽  
Donald C. Holt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility

scholarly journals Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q

2008 ◽  
Vol 53 (4) ◽  
pp. 314-324 ◽  
Author(s):  
F. Takeuchi ◽  
Y. Ochiai ◽  
M. Serizawa ◽  
K. Yanai ◽  
N. Kuzuya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility

scholarly journals Current Trend of Nutrigenomics of Geriatric Type 2 Diabetes

2021 ◽  
pp. 11-19
Author(s):  
Viola A. Nwachukwu Nicholas-Okpara ◽  
Ifesinachi Anastacia Utazi ◽  
Chika Scholastica Ezeanyanaso ◽  
Blossom Ita ◽  
Adaeze Joy Ukaba ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Studies ◽  
Current Trend ◽  
Susceptibility Genes ◽  
Genome Wide Association Studies ◽  
Global Public Health ◽  
Nutritional Recommendations ◽  
Genome Wide ◽  
Key Factor

Diabetes mellitus type 2 (T2DM) is a growing burden in the global public health and economic systems. Older adults are more than two times predisposed to T2DM and they are more likely to develop T2DM-related complications. A complex interaction of genes, diet and environment is a key factor in the development of this chronic metabolic disorder. With nutrigenomics, researchers are beginning to understand this interaction. This review aims at examining gene-diet relationships concerning T2DM as well as the applications and potential of nutrigenomics in managing geriatric type 2 diabetes. Several genome-wide association studies have documented susceptibility genes for T2DM. Among these genes are TCFL2, PPARGγ, CAP 10, ADBR3, DPARGCIA, and ENPP genes. Several bioactive compounds in foods have also been shown to act as switches on T2DM susceptibility genes, aiding in the progression or inhibition of the disease. These findings have helped in developing nutritional recommendations that are relevant to the management of T2DM particularly in carriers of these susceptibility genes. In this comprehensive review, the current trends, and prospects of nutrigenomics as an intervention for geriatric diabetes is explained.

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