scholarly journals Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity

Theranostics ◽  
2014 ◽  
Vol 4 (2) ◽  
pp. 215-228 ◽  
Author(s):  
Zhiyuan Hu ◽  
Christopher Lausted ◽  
Hyuntae Yoo ◽  
Xiaowei Yan ◽  
Amy Brightman ◽  
...  
Keyword(s):  
Specific Protein ◽  
Liver Specific Protein ◽  
Protein Fingerprint

The plasma membrane origin of liver-specific protein (LSP)

2008 ◽  
Vol 3 (4) ◽  
pp. 213-219 ◽  
Author(s):  
Donald M. Jensen ◽  
Cathie Hall ◽  
Terrance Majewski
Keyword(s):  
Plasma Membrane ◽  
Specific Protein ◽  
Liver Specific Protein

scholarly journals Reply of the authors: Liver Specific Protein—How Specific?

1980 ◽  
Vol 78 (6) ◽  
pp. 1663
Author(s):  
Ursula J. Behrens ◽  
Fiorenzo Paronetto
Keyword(s):  
Specific Protein ◽  
Liver Specific Protein

How specific is liver-specific protein?

1980 ◽  
Vol 79 (1) ◽  
pp. 179-180 ◽  
Author(s):  
Feighery Conleth ◽  
D.G. Weir
Keyword(s):  
Specific Protein ◽  
Liver Specific Protein

scholarly journals Liver-specific protein in perspective

1980 ◽  
Vol 78 (1) ◽  
pp. 168-170 ◽  
Author(s):  
Francis V. Chisari
Keyword(s):  
Specific Protein ◽  
Liver Specific Protein

Analysis of liver-specific protein LSP using murine monoclonal antibodies

1987 ◽  
Vol 17 (4) ◽  
pp. 360-367 ◽  
Author(s):  
T. PORALLA ◽  
M. MANNS ◽  
H. P. DIENES ◽  
W. DIPPOLD ◽  
T. H. HÜTTEROTH ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Specific Protein ◽  
Liver Specific Protein ◽  
Murine Monoclonal Antibodies

Induction of Hepatocyte Differentiation by the Extracellular Matrix and an RGD-Containing Synthetic Peptide

1991 ◽  
Vol 252 ◽  
Author(s):  
David J. Mooney ◽  
Robert Langer ◽  
Linda K. Hansen ◽  
Joseph P. Vacanti ◽  
Donald E. Ingber
Keyword(s):  
Extracellular Matrix ◽  
Protein Secretion ◽  
Synthetic Peptide ◽  
Cell Spreading ◽  
Specific Protein ◽  
Hepatocyte Differentiation ◽  
Liver Specific Protein ◽  
Extensive Cell ◽  
Adhesive Interactions

ABSTRACTTo design novel biomaterials for hepatocyte transplantation it will be necessary to determine whether specific extracellular matrix (ECM) molecule(s) or the adhesive interactions between the surface and hepatocytes are responsible for regulation of hepatocyte function. Purified ECM molecules (laminin, fibronectin, types I and IV collagen) and a synthetic peptide containing the arginine-glycine-aspartate (RGD) cell-binding sequence were precoated at defined densities to non-adhesive polystyrene dishes. Hepatocytes cultured on dishes coated with a low density of ECM molecules (1 ng/cm2) maintained a round morphology, and high liver-specific protein secretion rates. In contrast, culturing hepatocytes on increasing ECM densities (50–1000 ng/cm2) resulted in extensive cell spreading, a loss of liver-specific protein secretion, and cell growth. Hepatocytes cultured on dishes coated with the RGD-containing peptide did not spread even on a high density of the peptide (10,000 ng/cm2), and albumin secretion remained high for hepatocytes cultured on all peptide densities (1–10,000 ng/cm2). These results suggest that a variety of ECM molecules and synthetic peptides are capable of inducing hepatocyte differentiation in vitro, and these effects depend on their ability to promote cell spreading.

Synergistic Transactivation of HNF-1α, HNF-3, and NF-I Contributes to the Activation of the Liver-Specific Protein C Gene

1997 ◽  
Vol 16 (5) ◽  
pp. 569-577 ◽  
Author(s):  
WOEI TSAY ◽  
YU-MAY LEE ◽  
SHENG-CHUNG LEE ◽  
MING-CHING SHEN ◽  
PEI-JER CHEN
Keyword(s):  
Protein C ◽  
Specific Protein ◽  
Liver Specific Protein
Sign in / Sign up

Export Citation Format

Share Document