A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Ho Jin Lee; Hye-Young Min; Young-Sik Yong; Jihyae Ann; Cong Truong Nguyen; Minh Thanh La; Seung Yeob Hyun; Huong Thuy Le; Hyewon Kim; Hyukjin Kwon; Gibeom Nam; Hyun-Ju Park; Jeewoo Lee; Ho-Young Lee

doi:10.7150/thno.63788

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Theranostics ◽

10.7150/thno.63788 ◽

2022 ◽

Vol 12 (1) ◽

pp. 105-125

Author(s):

Ho Jin Lee ◽

Hye-Young Min ◽

Young-Sik Yong ◽

Jihyae Ann ◽

Cong Truong Nguyen ◽

...

Keyword(s):

Drug Resistance ◽

Heat Shock ◽

Adverse Effects ◽

Heat Shock Protein ◽

Heat Shock Protein 90

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Glycyrrhizin effects rat hepatocytes via the reduction of heat shock protein 90 expression

Gastroenterology ◽

10.1016/s0016-5085(01)81776-5 ◽

2001 ◽

Vol 120 (5) ◽

pp. A357-A357

Author(s):

T YOH ◽

T NAKASHIMA ◽

Y SUMIDA ◽

Y KAKISAKA ◽

H ISHIKAWA ◽

...

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Heat Shock Protein 90 ◽

Rat Hepatocytes

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430: Modulation of Heat-Shock Protein 90 (HSP90) Client Protein Expression in Prostate Cancer Cells by a Novel Novobiocin Analog

The Journal of Urology ◽

10.1016/s0022-5347(18)32686-7 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 140-140

Author(s):

Manlio A. Goetzl ◽

Brian S. Blagg ◽

Benjamin Cronk ◽

Len Neckers ◽

Jeffrey M. Holzbeierlein

Keyword(s):

Prostate Cancer ◽

Heat Shock ◽

Heat Shock Protein ◽

Protein Expression ◽

Cancer Cells ◽

Heat Shock Protein 90 ◽

Client Protein ◽

Prostate Cancer Cells ◽

Hsp90 Client Protein

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Faculty Opinions recommendation of High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1003609.201391 ◽

2003 ◽

Author(s):

Jen Sheen

Keyword(s):

Disease Resistance ◽

Heat Shock ◽

Heat Shock Protein ◽

Gene Silencing ◽

High Throughput ◽

Plant Disease Resistance ◽

Plant Disease ◽

Heat Shock Protein 90 ◽

Virus Induced Gene Silencing

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Faculty Opinions recommendation of Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082926.535884 ◽

2007 ◽

Author(s):

Homer Pearce

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Molecular Chaperone ◽

Heat Shock Protein 90

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Faculty Opinions recommendation of A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1120094.576229 ◽

2008 ◽

Author(s):

Richard Riedel

Keyword(s):

Growth Factor ◽

Heat Shock ◽

Heat Shock Protein ◽

Ewing Sarcoma ◽

Heat Shock Protein 90 ◽

Pivotal Role ◽

In Vivo Study ◽

Insulin Like Growth Factor

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Faculty Opinions recommendation of Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5285957.5228055 ◽

2010 ◽

Author(s):

Leonard Neckers

Keyword(s):

Plasmodium Falciparum ◽

Heat Shock ◽

Heat Shock Protein ◽

Drug Target ◽

Biochemical Characterization ◽

Heat Shock Protein 90 ◽

Trypanosoma Evansi ◽

Candidate Drug ◽

Protozoan Infections

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Faculty Opinions recommendation of Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717953651.793459252 ◽

2012 ◽

Author(s):

Norma A Bobadilla ◽

Jonatan Barrera Chimal

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Heat Shock Protein 90 ◽

Chaperone Activity ◽

Linker Sequence ◽

Hsp90 Chaperone

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Faculty Opinions recommendation of Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725560725.793524162 ◽

2016 ◽

Author(s):

Upinder Singh

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Entamoeba Histolytica ◽

Heat Shock Protein 90

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Faculty Opinions recommendation of Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9875965.10590064 ◽

2011 ◽

Author(s):

Leonard Neckers ◽

Mehdi Mollapour

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Histone Deacetylase ◽

T Regulatory Cells ◽

Heat Shock Protein 90 ◽

Regulatory Cells ◽

Histone Deacetylase 6

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Imaging Heat Shock Protein 90 (Hsp90) Activity in Hormone-Refractory Prostate Cancer

10.21236/ada506361 ◽

2009 ◽

Author(s):

Gang Niu

Keyword(s):

Prostate Cancer ◽

Heat Shock ◽

Heat Shock Protein ◽

Heat Shock Protein 90 ◽

Hormone Refractory Prostate Cancer ◽

Hsp90 Activity ◽

Hormone Refractory

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