scholarly journals Role of prostaglandin E2 in tissue repair and regeneration

Theranostics ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 8836-8854
Author(s):  
Hui Cheng ◽  
Haoyan Huang ◽  
Zhikun Guo ◽  
Ying Chang ◽  
Zongjin Li
Keyword(s):  
Prostaglandin E2 ◽  
Tissue Repair ◽  
Tissue Repair And Regeneration

scholarly journals Wnt signaling in kidney: the initiator or terminator?

2020 ◽  
Vol 98 (11) ◽  
pp. 1511-1523 ◽  
Author(s):  
Ping Meng ◽  
Mingsheng Zhu ◽  
Xian Ling ◽  
Lili Zhou
Keyword(s):  
Cell Differentiation ◽  
Embryonic Development ◽  
Wnt Signaling ◽  
Tissue Repair ◽  
Progenitor Cell ◽  
Kidney Development ◽  
Kidney Diseases ◽  
Electrolyte Balance ◽  
Tissue Repair And Regeneration

Abstract The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment, and fibrosis progression. All of these rely on the frequent occurrence of cell death and growth. Notably, to overcome disease, some cells regenerate through self-repair or progenitor cell differentiation. However, the signaling mechanisms underlying kidney development and regeneration have not been elucidated. Recently, Wnt signaling has been noted to play an important role. Although it is a well-known developmental signal, the role of Wnt signaling in kidney development and regeneration is not well recognized. In this review, we review the role of Wnt signaling in kidney embryonic development, tissue repair, cell division, and progenitor cell differentiation after injury. Moreover, we briefly highlight advances in our understanding of the pathogenic mechanisms of Wnt signaling in mediating cellular senescence in kidney parenchymal and stem cells, an irreversible arrest of cell proliferation blocking tissue repair and regeneration. We also highlight the therapeutic targets of Wnt signaling in kidney diseases and provide important clues for clinical strategies.

The role of cellular senescence in tissue repair and regeneration

2021 ◽  
pp. 111528
Author(s):  
Lucía Antelo-Iglesias ◽  
Pilar Picallos-Rabina ◽  
Valentín Estévez-Souto ◽  
Sabela Da Silva-Álvarez ◽  
Manuel Collado
Keyword(s):  
Cellular Senescence ◽  
Tissue Repair ◽  
Tissue Repair And Regeneration

scholarly journals The Role of Therapeutic Angiogenesis in Tissue Repair and Regeneration

2005 ◽  
Vol 18 (9) ◽  
pp. 501-502 ◽  
Author(s):  
William W. Li ◽  
Katherine Talcott ◽  
Amy Zhai ◽  
Erwin A. Kruger ◽  
Vincent W. Li
Keyword(s):  
Tissue Repair ◽  
Therapeutic Angiogenesis ◽  
Tissue Repair And Regeneration

The role of biomaterials in stem cell-based regenerative medicine

2019 ◽  
Vol 11 (14) ◽  
pp. 1777-1790 ◽  
Author(s):  
Xiangnan Zhao ◽  
Kaige Cui ◽  
Zongjin Li
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tissue Repair ◽  
Degenerative Diseases ◽  
Promising Alternative ◽  
Cell Behaviors ◽  
Tissue Repair And Regeneration ◽  
Alternative Approach ◽  
Translational Therapy

Stem cell therapy is a promising alternative approach to the treatment of a number of incurable degenerative diseases. However, low cell retention and survival after transplantation limit the therapeutic efficacy of stem cells for clinical translational applications. The utilization of biomaterials has been progressively successful in controlling the fate of transplanted cells by imitating the cellular microenvironment for optimal tissue repair and regeneration. This review mainly focuses on the engineered microenvironments with synthetic biomaterials in modification of stem cell behaviors. Moreover, the possible advancements in translational therapy by using biomaterials with stem cells are prospected and the challenges of the current restriction in clinical applications are highlighted.

The role of Interleukin 1 receptor antagonist in mesenchymal stem cell‐based tissue repair and regeneration

BioFactors ◽  
2020 ◽  
Vol 46 (2) ◽  
pp. 263-275 ◽  
Author(s):  
Carl Randall Harrell ◽  
Bojana Simovic Markovic ◽  
Crissy Fellabaum ◽  
Nebojsa Arsenijevic ◽  
Valentin Djonov ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Receptor Antagonist ◽  
Tissue Repair ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Tissue Repair And Regeneration

scholarly journals The Role of Therapeutic Angiogenesis in Tissue Repair and Regeneration

2005 ◽  
Vol 18 (9) ◽  
pp. 491-500 ◽  
Author(s):  
William W. Li ◽  
Katherine E. Talcott ◽  
Amy W. Zhai ◽  
Erwin A. Kruger ◽  
Vincent W. Li
Keyword(s):  
Tissue Repair ◽  
Therapeutic Angiogenesis ◽  
Tissue Repair And Regeneration

The role of microbiota in tissue repair and regeneration

2020 ◽  
Vol 14 (3) ◽  
pp. 539-555 ◽  
Author(s):  
Amin Shavandi ◽  
Pouya Saeedi ◽  
Philippe Gérard ◽  
Esmat Jalalvandi ◽  
David Cannella ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Tissue Repair And Regeneration
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