scholarly journals Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents

Theranostics ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1187-1203
Author(s):  
Jian Yu ◽  
Xin Chen ◽  
Yuanjin Zhang ◽  
Xiangdi Cui ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Beige Fat

Molecular regulation of brown and beige fat cell fate

2014 ◽  
Author(s):  
Patrick Seale ◽  
Wenshan Wang ◽  
Sona Rajakumari ◽  
Matthew Harms
Keyword(s):  
Cell Fate ◽  
Molecular Regulation ◽  
Fat Cell ◽  
Beige Fat

scholarly journals Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
De-Huang Guo ◽  
Masaki Yamamoto ◽  
Caterina M. Hernandez ◽  
Hesam Khodadadi ◽  
Babak Baban ◽  
...  
Keyword(s):  
Subcutaneous Fat ◽  
Visceral Obesity ◽  
Interleukin 4 ◽  
Hippocampal Synaptic Plasticity ◽  
Beige Adipocytes ◽  
Beige Fat ◽  
Dietary Obesity ◽  
Anti Inflammatory ◽  
Subcutaneous Adiposity ◽  
The Relationship

AbstractVisceral obesity increases risk of cognitive decline in humans, but subcutaneous adiposity does not. Here, we report that beige adipocytes are indispensable for the neuroprotective and anti-inflammatory effects of subcutaneous fat. Mice lacking functional beige fat exhibit accelerated cognitive dysfunction and microglial activation with dietary obesity. Subcutaneous fat transplantation also protects against chronic obesity in wildtype mice via beige fat-dependent mechanisms. Beige adipocytes restore hippocampal synaptic plasticity following transplantation, and these effects require the anti-inflammatory cytokine interleukin-4 (IL4). After observing beige fat-mediated induction of IL4 in meningeal T-cells, we investigated the contributions of peripheral lymphocytes in donor fat. There was no sign of donor-derived lymphocyte trafficking between fat and brain, but recipient-derived lymphocytes were required for the effects of transplantation on cognition and microglial morphology. These findings indicate that beige adipocytes oppose obesity-induced cognitive impairment, with a potential role for IL4 in the relationship between beige fat and brain function.

scholarly journals Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Cell ◽  
2014 ◽  
Vol 157 (6) ◽  
pp. 1279-1291 ◽  
Author(s):  
Rajesh R. Rao ◽  
Jonathan Z. Long ◽  
James P. White ◽  
Katrin J. Svensson ◽  
Jesse Lou ◽  
...  
Keyword(s):  
Beige Fat

BIOBOARD

2016 ◽  
Vol 20 (03) ◽  
pp. 49-58
Keyword(s):  
United States ◽  
Drug Targets ◽  
Brain Cell ◽  
Medical Cannabis ◽  
Chemical Safety ◽  
Safety Testing ◽  
Beige Fat ◽  
Advance Research ◽  
Out Of Africa ◽  
Autism Treatments

SINGAPORE – International Collaboration to Advance Research on Non-Animal Approaches to Chemical Safety Testing. UNITED STATES – Coriell Institute Licenses PluriTest, a Novel Stem Cell Technology. UNITED STATES – Tackling World's Problems with Human-Computer Intelligence. UNITED STATES – Untapped Region in Brain Cell Offers Goldmine of Drug Targets for New Autism Treatments, UCLA Study Finds. UNITED STATES – Activating Beige Fat in Humans Could Combat Obesity. UNITED STATES – Cancer-Killing Proteins Destroy Tumor Cells in Bloodstream. UNITED STATES – Measuring the Mechanical Forces of Disease. UNITED STATES – Scientists Identify Molecule That Appears to Fuel Deadly Genetic Illness. AUSTRALIA – Medlab Supports New Federal Legislation for Medical Cannabis. UNITED KINGDOM – BioAscent Expands Compound Management Services Offering with Pierre Fabre Collaboration. SWITZERLAND – Harmful Mutations Have Accumulated during Early Human Migrations Out of Africa. JAPAN – BIOTRONIK's Itrevia 7 HF-T is First CRT-D Approved for Full-Body MRI Scanning in Japan.

scholarly journals Transcriptional Control of Brown and Beige Fat Development and Function

Obesity ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Suzanne N. Shapira ◽  
Patrick Seale
Keyword(s):  
Transcriptional Control ◽  
Beige Fat ◽  
And Function

scholarly journals Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes

2020 ◽  
Vol 245 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Zhe-Zhen Liao ◽  
Xiao-Yan Qi ◽  
Ya-Di Wang ◽  
Jiao-Yang Li ◽  
Qian-Qian Gu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ampk Signaling ◽  
White Adipocytes ◽  
Beige Adipocytes ◽  
Beige Fat ◽  
Mitochondria Biogenesis ◽  
Paracrine Actions ◽  
White Fat

Remodeling of energy-storing white fat into energy-consuming beige fat has led to a promising new approach to alleviate adiposity. Several studies have shown adipokines can induce white adipose tissue (WAT) beiging through autocrine or paracrine actions. Betatrophin, a novel adipokine, has been linked to energy expenditure and lipolysis but not clearly clarified. Here, we using high-fat diet-induced obesity to determine how betatrophin modulate beiging and adiposity. We found that betatrophin-knockdown mice displayed less white fat mass and decreased plasma TG and NEFA levels. Consistently, inhibition of betatrophin leads to the phenotype change of adipocytes characterized by increased mitochondria contents, beige adipocytes and mitochondria biogenesis-specific markers both in vivo and in vitro. Of note, blocking AMP-activated protein kinase (AMPK) signaling pathway is able to abolish enhanced beige-like characteristics in betatrophin-knockdown adipocytes. Collectively, downregulation of betatrophin induces beiging in white adipocytes through activation of AMPK signaling pathway. These processes suggest betatrophin as a latent therapeutic target for obesity.

scholarly journals LIGHT/TNFSF14 signaling attenuates beige fat biogenesis

2018 ◽  
Vol 33 (2) ◽  
pp. 1595-1604 ◽  
Author(s):  
Yanbo Kou ◽  
Qingya Liu ◽  
Wenli Liu ◽  
Hongxiang Sun ◽  
Ming Liang ◽  
...  
Keyword(s):  
Beige Fat

scholarly journals Insights into the neurochemical signature of the Innervation of Beige Fat

2018 ◽  
Vol 11 ◽  
pp. 47-58 ◽  
Author(s):  
Aneta Stefanidis ◽  
Nicole M. Wiedmann ◽  
Sonika Tyagi ◽  
Andrew M. Allen ◽  
Matthew J. Watt ◽  
...  
Keyword(s):  
Beige Fat
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