scholarly journals Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions

Theranostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 470-490
Author(s):  
Roman Mehling ◽  
Johannes Schwenck ◽  
Christina Lemberg ◽  
Christoph Trautwein ◽  
Laimdota Zizmare ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
T Cell ◽  
Reactive Oxygen ◽  
Delayed Type Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Oxygen Species ◽  
Nitrogen Species

Role of Reactive Oxygen Species in T-Cell Defects in Cancer

2007 ◽  
pp. 259-280
Author(s):  
Alex Corzo ◽  
Srinivas Nagaraj ◽  
Dmitry I. Gabrilovich
Keyword(s):  
Reactive Oxygen Species ◽  
T Cell ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Key Role of Reactive Oxygen Species (ROS) in Indirubin Derivative-Induced Cell Death in Cutaneous T-Cell Lymphoma Cells

2019 ◽  
Vol 20 (5) ◽  
pp. 1158 ◽  
Author(s):  
Marwa Soltan ◽  
Uly Sumarni ◽  
Chalid Assaf ◽  
Peter Langer ◽  
Ulrich Reidel ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
T Cell ◽  
Cell Lymphoma ◽  
Reactive Oxygen ◽  
T Cell Lymphoma ◽  
Strong Increase ◽  
Oxygen Species ◽  
Cutaneous T Cell Lymphoma ◽  
Early Effect

Cutaneous T-cell lymphoma (CTCL) may develop a highly malignant phenotype in its late phase, and patients may profit from innovative therapies. The plant extract indirubin and its chemical derivatives represent new and promising antitumor strategies. This first report on the effects of an indirubin derivative in CTCL cells shows a strong decrease of cell proliferation and cell viability as well as an induction of apoptosis, suggesting indirubin derivatives for therapy of CTCL. As concerning the mode of activity, the indirubin derivative DKP-071 activated the extrinsic apoptosis cascade via caspase-8 and caspase-3 through downregulation of the caspase antagonistic proteins c-FLIP and XIAP. Importantly, a strong increase of reactive oxygen species (ROS) was observed as an immediate early effect in response to DKP-071 treatment. The use of antioxidative pre-treatment proved the decisive role of ROS, which turned out upstream of all other proapoptotic effects monitored. Thus, reactive oxygen species appear as a highly active proapoptotic pathway in CTCL, which may be promising for therapeutic intervention. This pathway can be efficiently activated by an indirubin derivative.

Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

2004 ◽  
Vol 287 (2) ◽  
pp. C246-C256 ◽  
Author(s):  
Henry Jay Forman ◽  
Jon M. Fukuto ◽  
Martine Torres
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Second Messengers ◽  
Large Body ◽  
Reactive Oxygen ◽  
Protein Tyrosine Phosphatases ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Signaling Components

Except for the role of NO in the activation of guanylate cyclase, which is well established, the involvement of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in signal transduction remains controversial, despite a large body of evidence suggestive of their participation in a variety of signaling pathways. Several problems have limited their acceptance as signaling molecules, with the major one being the difficulty in identifying the specific targets for each pathway and the chemical reactions supporting reversible oxidation of these signaling components, consistent with a second messenger role for ROS and RNS. Nevertheless, it has become clear that cysteine residues in the thiolate (i.e., ionized) form that are found in some proteins can be specific targets for reaction with H2O2 and RNS. This review focuses on the chemistry of the reversible oxidation of those thiolates, with a particular emphasis on the critical thiolate found in protein tyrosine phosphatases as an example.

Effects of polyphenols in aging and neurodegeneration associated with oxidative stress

2021 ◽  
Vol 28 ◽  
Author(s):  
Francisca Rivas ◽  
Carlos Poblete-Aro ◽  
María Elsa Pando ◽  
María José Allel ◽  
Valentina Fernandez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Over Time

: Aging is defined as the functional loss of tissues and organs over time. This is a biological, irreversible, progressive, and universal process that results from genetic and environmental factors, such as diet, physical activity, smoking, harmful alcohol consumption, and exposure to toxins, among others. Aging is a consequence of molecular and cellular damage built up over time. This damage begins with a gradual decrease in physical and mental capacity, thus increasing the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Neuronal, functional, and structural damage can be explained by an imbalance among free radicals, reactive oxygen species, reactive nitrogen species, and antioxidants, which finally lead to oxidative stress. Due to the key role of free radicals, reactive oxygen species, and reactive nitrogen species, antioxidant therapy may reduce the oxidative damage associated with neurodegeneration. Exogenous antioxidants are molecules that may help maintain the balance between the formation and elimination of free radicals, thus protecting the cell from their toxicity. Among them, polyphenols are a broad group of secondary plant metabolites with potent antioxidant properties. Here, we review several studies that show the potential role of polyphenol consumption to prevent, or slow down, harmful oxidative processes linked to neurodegenerative disorders.

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