scholarly journals Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis

Theranostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 715-730
Author(s):  
Zhao-Lan Hu ◽  
Cong Luo ◽  
Plinio Reinaldo Hurtado ◽  
Hui Li ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune System ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Novel Target

The rs2030324 SNP of brain-derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis

2011 ◽  
Vol 18 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Bianca Weinstock-Guttman ◽  
Ralph H.B. Benedict ◽  
Miriam Tamaño-Blanco ◽  
Deepa Preeti Ramasamy ◽  
Milena Stosic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Processing ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Visual Cognitive

scholarly journals Interleukin-10 and brain-derived neurotrophic factor responses to the Mat Pilates training in women with multiple sclerosis

2018 ◽  
Vol 28 (4) ◽  
pp. 31668
Author(s):  
Elham Eftekhari ◽  
Masoud Etemadifar
Keyword(s):  
Multiple Sclerosis ◽  
Neurotrophic Factor ◽  
Training Group ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Interleukin 10 ◽  
Analysis Of Covariance ◽  
Control Group ◽  
P Value ◽  
Before And After

AIMS: To determine the effect of Mat Pilates on serum levels of interleukin-10 and brain-derived neurotrophic factor in women with multiple sclerosis.METHODS: Thirty women with multiple sclerosis with mild to moderate disability were recruited and randomly divided into equal Pilates training and Control groups. Patients in the training group accomplished a Pilates program three times a week for eight weeks. The Control group maintained their routine lifestyle. The serum level of interleukin-10 and brain-derived neurotrophic factor were measured before and after the protocol. The differences between groups were assessed by using analysis of covariance test to compare post-tests by considering covariate pre-tests (assuming a p-value <0.05 as significant).RESULTS: There were no significant changes in interleukin-10 (13.09±5.36 ng/ml in the Pilates training group compared to 13.21±4.76 ng/ml in the Control group, p= 0.81), whereas an increase in brain-derived neurotrophic factor was observed after eight-week Pilates training (11550.14±2619.60 ng/ml in the Pilates training group compared to 9664.35±3161.66 ng/ml in the Control group, p= 0.03).CONCLUSIONS: The results suggest that the intensity and duration of this protocol was not related to significant changes in interleukin-10, but was followed by an increase in brain-derived neurotrophic factor in these patients. Based on this finding, physical activity according to the individual’s ability is recommended for patients with multiple sclerosis, in parallel with drug therapy.

Altered serum content of brain-derived neurotrophic factor isoforms in multiple sclerosis

2012 ◽  
Vol 320 (1-2) ◽  
pp. 161-165 ◽  
Author(s):  
Enrico Tongiorgi ◽  
Arianna Sartori ◽  
Gabriele Baj ◽  
Alessio Bratina ◽  
Francesco Di Cola ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Altered Serum
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