scholarly journals H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts

Theranostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 1473-1492
Author(s):  
Ying Zhang ◽  
Zhaoyong Liu ◽  
Xia Yang ◽  
Weiqing Lu ◽  
Yelong Chen ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Cancer Associated Fibroblasts ◽  
Pulmonary Cancer

scholarly journals Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

2021 ◽  
Vol 9 ◽  
Author(s):  
Xueke Shi ◽  
Jingjing Luo ◽  
Kelsey J. Weigel ◽  
Spencer C. Hall ◽  
Danfeng Du ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lung Metastasis ◽  
Squamous Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Cancer Associated Fibroblasts ◽  
Tgfβ Receptor ◽  
Cell Niche

Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4–/– mouse SCCs. RNA expression analyses demonstrated that CAFs had enriched transforming growth factor-beta (TGFβ) signaling compared to normal tissue-associated fibroblasts (NAFs), therefore we assessed how TGFβ-enriched CAFs impact SCC metastasis. We co-injected SCC cells with CAFs to the skin, tail vein, or the lung to mimic sequential steps of lung metastasis. CAFs increased SCC volume only in lung co-transplantations, characterized with increased proliferation and angiogenesis and decreased apoptosis compared to NAF co-transplanted SCCs. These CAF effects were attenuated by a clinically relevant TGFβ receptor inhibitor, suggesting that CAFs facilitated TGFβ-dependent SCC cell seeding and survival in the lung. CAFs also increased tumor volume when co-transplanted to the lung with limiting numbers of SCC cancer stem cells (CSCs). In vitro, CSC sphere formation and invasion were increased either with co-cultured CAFs or with CAF conditioned media (which contains the highest TGFβ1 concentration) and these CAF effects were blocked by TGFβ inhibition. Further, TGFβ activation was higher in primary human oral SCCs with lung metastasis than SCCs without lung metastasis. Similarly, TGFβ activation was detected in the lungs of mice with micrometastasis. Our data suggest that TGFβ-enriched CAFs play a causal role in CSC seeding and expansion in the lung during SCC metastasis, providing a prognostic marker and therapeutic target for SCC lung metastasis.

Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma?

2000 ◽  
Vol 37 (2) ◽  
pp. 193-194 ◽  
Author(s):  
T Takeuchi ◽  
A Misaki ◽  
H Sonobe ◽  
S-B Liang ◽  
Y Ohtsuki
Keyword(s):  
Lung Metastasis

1011: Suppression of Renal Cell Carcinoma Lung Metastasis by Adeno-Associated Virus (AAV) Mediated Gene Transfer of a Soluble Receptor of VEGF

2004 ◽  
Vol 171 (4S) ◽  
pp. 267-267
Author(s):  
Ichiro Yoshimura ◽  
Yasunori Mizuguchi ◽  
Akira Miyajima ◽  
Tomohiko Asano ◽  
Hiroaki Mizukami ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Gene Transfer ◽  
Cell Carcinoma ◽  
Lung Metastasis ◽  
Renal Cell ◽  
Soluble Receptor ◽  
Adeno Associated Virus

Deoxyelephantopin suppresses lung metastasis of B16 melanoma in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
W Chao ◽  
Y Cheng ◽  
S Lee ◽  
L Shyur
Keyword(s):  
Lung Metastasis ◽  
B16 Melanoma

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

Author response for "Role of Platelet C‐Type Lectin‐Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma"

2020 ◽  
Author(s):  
Jiro Ichikawa ◽  
Takashi Ando ◽  
Tomonori Kawasaki ◽  
Tomoyuki Sasaki ◽  
Toshiaki Shirai ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Author Response

Defective lung CD8+ T cells lacking NFATc2 induced lung metastasis in NFATc2 deficient mice in a bronchoalveolar adenocarcinoma murine model

Pneumologie ◽  
2007 ◽  
Vol 61 (01) ◽  
Author(s):  
JH Maxeiner ◽  
R Karwot ◽  
K Sauer ◽  
P Scholtes ◽  
R Wiewrodt ◽  
...  
Keyword(s):  
T Cells ◽  
Lung Metastasis ◽  
Cd8 T Cells ◽  
Murine Model ◽  
Deficient Mice

Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis

Pathology ◽  
1990 ◽  
Vol 22 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Julia A. Bridge ◽  
Warren G. Sanger ◽  
James R. Neff ◽  
Michelle M. Hess
Keyword(s):  
Lung Metastasis ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma
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