scholarly journals Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis

Theranostics ◽  
2020 ◽  
Vol 10 (26) ◽  
pp. 11950-11962
Author(s):  
Li Sun ◽  
Chao Huang ◽  
Miaolin Zhu ◽  
Shuwei Guo ◽  
Qiuzhi Gao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell

scholarly journals Gastric Cancer Stem Cells

2008 ◽  
Vol 26 (17) ◽  
pp. 2876-2882 ◽  
Author(s):  
Shigeo Takaishi ◽  
Tomoyuki Okumura ◽  
Timothy C. Wang
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Cancer Biology ◽  
Human Cancer ◽  
Immunodeficient Mice

Cancer stem cells are defined as the unique subpopulation in the tumors that possess the ability to initiate tumor growth and sustain self-renewal as well as metastatic potential. Accumulating evidence in recent years strongly indicate the existence of cancer stem cells in solid tumors of a wide variety of organs. In this review, we will discuss the possible existence of a gastric cancer stem cell. Our recent data suggest that a subpopulation with a defined marker shows spheroid colony formation in serum-free media in vitro, as well as tumorigenic ability in immunodeficient mice in vivo. We will also discuss the possible origins of the gastric cancer stem cell from an organ-specific stem cell versus a recently recognized new candidate bone marrow–derived cell (BMDC). We have previously shown that BMDC contributed to malignant epithelial cells in the mouse model of Helicobacter-associated gastric cancer. On the basis of these findings from animal model, we propose that a similar phenomenon may also occur in human cancer biology, particularly in the cancer origin of other inflammation-associated cancers. The expanding research field of cancer stem-cell biology may offer a novel clinical apparatus to the diagnosis and treatment of cancer.

scholarly journals MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831770165 ◽  
Author(s):  
Narjes Jafari ◽  
Saeid Abediankenari
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Patient Treatment ◽  
Small Subset ◽  
Aberrant Expression ◽  
Wide Range ◽  
Gastric Cancer Stem Cells

Gastric cancer is a major cause of cancer mortality worldwide, with a low survival rate for patients with advanced forms of the disease. Over the recent decades, the investigation of the pathophysiological mechanisms of tumourigenesis has opened promising avenues to understand some of the complexities of cancer treatment. However, tumour regeneration and metastasis impose great difficulty for gastric cancer cure. In recent years, cancer stem cells – a small subset of tumour cells in many cancers – have become a major focus of cancer research. Cancer stem cells are capable of self-renewal and are known to be responsible for tumour initiation, metastasis, therapy resistance and cancer recurrence. Recent studies have revealed the key role of microRNAs – small noncoding RNAs regulating gene expression – in these processes. MicroRNAs play crucial roles in the regulation of a wide range of biological processes in a post-transcriptional manner, though their expression is dysregulated in most malignancies, including gastric cancer. In this article, we review the consequences of aberrant expression of microRNA-34 in cancer and cancer stem cells, with a specific focus on the miR-34 dysregulation in gastric cancer and gastric cancer stem cells. We address the critical effects of the aberrant expression of miR-34 and its target genes in maintaining cancer stem cell properties. Information collection and discussion about the advancements in gastric cancer stem cells and microRNAs can be useful for providing novel insights into patient treatment.

scholarly journals Mesenchymal stem cells show little tropism for the resting and differentiated cancer stem cell-like glioma cells

2014 ◽  
Vol 44 (4) ◽  
pp. 1223-1232 ◽  
Author(s):  
ZHENLIN LIU ◽  
ZHONGMIN JIANG ◽  
JIANYONG HUANG ◽  
SHUQIANG HUANG ◽  
YANXIA LI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Glioma Cells

128 Therapeutic Potential of Human Adipose Stem Cells in a Cancer Stem Cell-Like Gastric Cancer Cell Model

2012 ◽  
Vol 142 (5) ◽  
pp. S-31
Author(s):  
Guangming Liu ◽  
Hui Dai ◽  
Michael W Neumeister ◽  
Joel Reichensperger ◽  
Russell D. Yang
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Therapeutic Potential ◽  
Cell Model ◽  
Adipose Stem Cells ◽  
Human Adipose Stem Cells
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