Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor

Ho Jin Lee; Phuong Chi Pham; Honglan Pei; Bumhee Lim; Seung Yeob Hyun; Byungyeob Baek; Byungjin Kim; Yunha Kim; Min-Hwan Kim; Nae-Won Kang; Hye-Young Min; Dae-Duk Kim; Jeeyeon Lee; Ho-Young Lee

doi:10.7150/thno.48865

Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor

Theranostics ◽

10.7150/thno.48865 ◽

2021 ◽

Vol 11 (4) ◽

pp. 1918-1936

Author(s):

Ho Jin Lee ◽

Phuong Chi Pham ◽

Honglan Pei ◽

Bumhee Lim ◽

Seung Yeob Hyun ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Insulin Like Growth Factor ◽

Small Molecule Kinase Inhibitor

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis

European Journal of Cancer ◽

10.1016/j.ejca.2008.04.003 ◽

2008 ◽

Vol 44 (11) ◽

pp. 1577-1586 ◽

Cited By ~ 47

Author(s):

Christian Moser ◽

Philipp Schachtschneider ◽

Sven A. Lang ◽

Andreas Gaumann ◽

Akira Mori ◽

...

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Small Molecule ◽

Kinase Inhibitor ◽

Cancer Growth ◽

Insulin Like Growth Factor ◽

Factor I ◽

Small Molecule Kinase Inhibitor ◽

Growth Factor I

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Advances towards the Development of ATP-Competitive Small-Molecule Inhibitors of the Insulin-Like Growth Factor Receptor (IGF-IR)

ChemMedChem ◽

10.1002/cmdc.200600174 ◽

2007 ◽

Vol 2 (1) ◽

pp. 41-46 ◽

Cited By ~ 11

Author(s):

Robert D. Hubbard ◽

Julie L. Wilsbacher

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Insulin Like Growth Factor

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Advances Towards the Development of ATP-Competitive Small-Molecule Inhibitors of the Insulin-Like Growth Factor Receptor (IGF-IR)

ChemInform ◽

10.1002/chin.200715238 ◽

2007 ◽

Vol 38 (15) ◽

Author(s):

Robert D. Hubbard ◽

Julie L. Wilsbacher

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Growth Factor Receptor ◽

Insulin Like Growth Factor

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Preclinical and first‐in‐human phase I studies of KW ‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

Cancer Science ◽

10.1111/cas.12906 ◽

2016 ◽

Vol 107 (4) ◽

pp. 499-506 ◽

Cited By ~ 15

Author(s):

Gary K. Schwartz ◽

Mark A. Dickson ◽

Patricia M. LoRusso ◽

Edward A. Sausville ◽

Yoshimi Maekawa ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Phase I ◽

Insulin Receptor ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Insulin Like Growth Factor ◽

Phase I Studies ◽

Receptor Selectivity

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Choosing between isotretinoin and acitretin for epidermal growth factor receptor inhibitor and small molecule tyrosine kinase inhibitor acneiform eruptions

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2020.09.090 ◽

2020 ◽

Author(s):

Collin M. Costello ◽

Hannah E. Hill ◽

Caitlin M. Brumfiel ◽

Yul W. Yang ◽

David L. Swanson

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Small Molecule ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Receptor Inhibitor

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Abstract 3858: Gains in FGF19 are predictive of response to the fibroblast growth factor receptor (FGFR) small molecule tyrosine kinase inhibitor BGJ 398in vitro

10.1158/1538-7445.am2012-3858 ◽

2012 ◽

Cited By ~ 5

Author(s):

Richard S. Finn ◽

Alex Aleshin ◽

Danyun Zhao ◽

Lee Anderson ◽

Charles Ginther ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Fibroblast Growth Factor ◽

Small Molecule ◽

Fibroblast Growth Factor Receptor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Fibroblast Growth

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Phase II Data with ZD6474, a Small-Molecule Kinase Inhibitor of Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor, in Previously Treated Advanced Non–Small-Cell Lung Cancer

Clinical Lung Cancer ◽

10.1016/s1525-7304(11)70394-1 ◽

2005 ◽

Vol 7 (2) ◽

pp. 89-91 ◽

Cited By ~ 18

Author(s):

David Lee ◽

Ronald B. Natale ◽

Eric Nadler ◽

Vinay K. Jain

Keyword(s):

Growth Factor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Small Cell ◽

Vascular Endothelial ◽

Small Cell Lung ◽

Small Molecule Kinase Inhibitor ◽

Previously Treated ◽

Epidermal Growth ◽

Endothelial Growth Factor

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The insulin-like growth factor receptor is a promising target for innovative treatment approaches of hepatocellular cancer

Zeitschrift für Gastroenterologie ◽

10.1055/s-2005-920140 ◽

2005 ◽

Vol 43 (05) ◽

Cited By ~ 1

Author(s):

M Höpfner ◽

A Hüther ◽

V Baradari ◽

D Schuppan ◽

H Scherübl

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Hepatocellular Cancer ◽

Insulin Like Growth Factor ◽

Treatment Approaches ◽

Innovative Treatment ◽

Promising Target

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The behaviour of matrix metalloproteinase-9, hepatocyte growth factor receptor and insulin-like growth factor receptor-I expressions in ulcerative colitis

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-943409 ◽

2006 ◽

Vol 44 (05) ◽

Author(s):

L Herszényi ◽

F Sipos ◽

O Galamb ◽

I Hritz ◽

B Győrffy ◽

...

Keyword(s):

Ulcerative Colitis ◽

Growth Factor ◽

Matrix Metalloproteinase ◽

Hepatocyte Growth Factor ◽

Growth Factor Receptor ◽

Matrix Metalloproteinase 9 ◽

Insulin Like Growth Factor ◽

Hepatocyte Growth Factor Receptor ◽

Metalloproteinase 9 ◽

Hepatocyte Growth

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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

10.32388/jfobd7 ◽

2020 ◽

Author(s):

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Receptor Tyrosine Kinase Inhibitor ◽

Epidermal Growth

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