scholarly journals Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis

Theranostics ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 8624-8639
Author(s):  
Meng Zhang ◽  
Wenhai Sui ◽  
Yanqiu Xing ◽  
Jing Cheng ◽  
Cheng Cheng ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Angiotensin Iv

167-OR: Activation of Myocardial Mitochondria Akt1 Improved Diabetic Cardiomyopathy and Body Composition—The Heart as a Metabolic Organ

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 167-OR
Author(s):  
YU-HAN CHEN ◽  
ALBERT TA ◽  
HSIAOCHEN LEE ◽  
HUGO YOU-HSIEN LIN ◽  
YUMAY CHEN ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Cardiomyopathy ◽  
Myocardial Mitochondria

Novel "Dual Hit" Rat Model of Diabetic Cardiomyopathy

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 466-P ◽  
Author(s):  
LOUISE THISTED ◽  
ROSS T. LINDSAY ◽  
KELD FOSGERAU ◽  
THOMAS SECHER ◽  
MORTEN B. THOMSEN ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Rat Model

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 186-OR
Author(s):  
RICCARDO PERFETTI ◽  
FRANCESCA C. LAWSON ◽  
JULIO ROSENSTOCK ◽  
JAMES JANUZZI ◽  
SHOSHANA SHENDELMAN ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Cardiomyopathy ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Pivotal Trial ◽  
Next Generation

Beneficial effects of verapamil in diabetic cardiomyopathy

Diabetes ◽  
1988 ◽  
Vol 37 (7) ◽  
pp. 936-942 ◽  
Author(s):  
N. Afzal ◽  
P. K. Ganguly ◽  
K. S. Dhalla ◽  
G. N. Pierce ◽  
P. K. Singal ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Beneficial Effects

Diabetic Cardiomyopathy: From Mechanism to Management in a Nutshell

2020 ◽  
Vol 20 ◽  
Author(s):  
Shahzad Khan ◽  
Syed S. Ahmad ◽  
Mohammad A. Kamal
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Immune Modulation ◽  
Cell Injury ◽  
Interstitial Fibrosis ◽  
Systolic Dysfunction ◽  
Therapeutic Strategies ◽  
Cardiac Cell ◽  
Clinical Heart Failure ◽  
Artery Disease ◽  
Apoptosis And Necrosis

: Diabetic cardiomyopathy (DCM) is a significant complication of diabetes mellitus characterized by gradual failing heart with detrimental cardiac remodellings such as fibrosis and diastolic and systolic dysfunction, which is not directly attributable to coronary artery disease. Insulin resistance and resulting hyperglycemia is the main trigger involved in the initiation of diabetic cardiomyopathy. There is a constellation of many pathophysiological events such as lipotoxicity, oxidative stress, inflammation, inappropriate activation of the renin-angiotensin-aldosterone system, dysfunctional immune modulation promoting increased rate of cardiac cell injury, apoptosis, and necrosis which ultimately culminates into interstitial fibrosis, cardiac stiffness, diastolic dysfunction initially and later systolic dysfunction too. These events finally lead to clinical heart failure of DCM. Herein, we have briefly discussed the pathophysiology of DCM. We have also briefly mentioned potential therapeutic strategies currently used for DCM.

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

2020 ◽  
Vol 20 (7) ◽  
pp. 1117-1132
Author(s):  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ismaeel Bin-Jaliah ◽  
Medhat Taha ◽  
Lashin S. Lashin
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Caspase 3 ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Control Group ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic

Background and Aims: In the current work, we studied the effects of exercise and stevia rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible underlying mechanisms. Methods: : Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c) DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts: type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues were measured. Results: T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2 and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05). On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05). Conclusion: Both exercise and methanolic stevia R extracts showed cardioprotective effects against DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.

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