scholarly journals Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder

Theranostics ◽  
2020 ◽  
Vol 10 (21) ◽  
pp. 9702-9720
Author(s):  
Junjian Hu ◽  
Hongwu Wang ◽  
Xitang Li ◽  
Yonggang Liu ◽  
Yuqiang Mi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Lipid Metabolism ◽  
Lipid Metabolism Disorder ◽  
Hepatic Lipid ◽  
Metabolism Disorder

Hepatic Lipid Metabolism Disorder and Atherosclerosis

2021 ◽  
Vol 22 ◽  
Author(s):  
Sen Zhang ◽  
Fenfang Hong ◽  
Chen Ma ◽  
Shulong Yang
Keyword(s):  
Lipid Metabolism ◽  
Experimental Studies ◽  
Cholesterol Transport ◽  
Hepatic Lipid Metabolism ◽  
Lipid Metabolism Disorder ◽  
Hepatic Lipid ◽  
Metabolism Disorder ◽  
Lipid Metabolism Disorders ◽  
And Oxidative Stress

: Lipid metabolism disorder plays a fundamental role in the pathogenesis of atherosclerosis. As the largest metabolic organ of the human body, liver has a key role in lipid metabolism by influencing fat production, fat decomposition, and the intake and secretion of serum lipoproteins. Numerous clinical and experimental studies have indicated that the dysfunction of hepatic lipid metabolism is closely tied to the onset of atherosclerosis. However, the identity and functional role of hepatic lipid metabolism responsible for these associations remain unknown. This review presented that cholesterol synthesis, cholesterol transport, and the metabolism of triglyceride, lipoproteins, and fatty acids are all associated with hepatic lipid metabolism and atherosclerosis. Moreover, we also discussed the roles of gut microbiota, inflammatory response, and oxidative stress in the pathological association between hepatic lipid metabolism and atherosclerosis. These significant evidences support strongly that hepatic lipid metabolism disorders may increase the risk of atherosclerosis.

scholarly journals Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

2018 ◽  
Vol Volume 13 ◽  
pp. 7303-7318 ◽  
Author(s):  
Junchao Duan ◽  
Shuang Liang ◽  
Lin Feng ◽  
Yang Yu ◽  
Zhiwei Sun
Keyword(s):  
Lipid Metabolism ◽  
Silica Nanoparticles ◽  
Hepatic Lipid Metabolism ◽  
Lipid Metabolism Disorder ◽  
Hepatic Lipid ◽  
Metabolism Disorder

Crocin-I ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice

2019 ◽  
Vol 10 (10) ◽  
pp. 6779-6791 ◽  
Author(s):  
Xiaoxian Xie ◽  
Qingfeng Xiao ◽  
Ze Xiong ◽  
Chunan Yu ◽  
Jiafeng Zhou ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Side Effects ◽  
Gut Microbiota ◽  
Hepatic Lipid Metabolism ◽  
Lipid Metabolism Disorder ◽  
Hepatic Lipid ◽  
Metabolism Disorder

Crocin-I mitigates the side effects of glucocorticoids treatment, mainly in reducing hepatic lipid metabolism disorder and dysbiosis of gut microbiota.

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