scholarly journals Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis

Theranostics ◽  
2020 ◽  
Vol 10 (16) ◽  
pp. 7319-7334 ◽  
Author(s):  
Haoran Liu ◽  
Xiaoqi Yang ◽  
Kun Tang ◽  
Tao Ye ◽  
Chen Duan ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Therapeutic Effects ◽  
Crystal Deposition ◽  
Inflammatory Injury

scholarly journals Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis: Erratum

Theranostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 421-421
Author(s):  
Haoran Liu ◽  
Xiaoqi Yang ◽  
Kun Tang ◽  
Tao Ye ◽  
Chen Duan ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Therapeutic Effects ◽  
Crystal Deposition ◽  
Inflammatory Injury

Metformin elicits dual therapeutic effects on renal inflammatory and oxidative injury in calcium oxalate nephrocalcinosis

2021 ◽  
Vol 79 ◽  
pp. S319-S320
Author(s):  
C. Duan ◽  
H. Liu ◽  
T. Ye ◽  
X. Yang ◽  
P. Lv ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Oxidative Injury ◽  
Therapeutic Effects

Renal Cell Carcinoma With Intratumoral Calcium Oxalate Crystal Deposition in Patients With Acquired Cystic Disease of the Kidney

2003 ◽  
Vol 127 (2) ◽  
pp. e89-e92
Author(s):  
Nathalie C. Rioux-Leclercq ◽  
Jonathan I. Epstein
Keyword(s):  
Renal Cell Carcinoma ◽  
Calcium Oxalate ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Cystic Disease ◽  
Calcium Oxalate Crystal ◽  
Cell Renal Cell Carcinoma ◽  
Crystal Deposition ◽  
Acquired Cystic Disease

Abstract We describe 2 cases of renal cell carcinoma arising in acquired cystic disease of the kidney (ACDK) in patients with end-stage renal disease undergoing hemodialysis for more than 5 years and provide a brief review of the complications of ACDK. In both cases, abundant calcium oxalate crystals were observed within the tumors. Histologically, one of the tumors was a conventional (clear cell) renal cell carcinoma. The other tumor was a bilateral papillary renal cell carcinoma. Both tumors were high-grade carcinomas with extensive oncocytic (acidophilic) features. Also noted within the kidneys were cysts with atypical papillary hyperplasia. The clinicopathologic findings along with review of the literature suggest a relationship between tumor growth and calcium oxalate crystal deposition in patients undergoing hemodialysis with ACDK.

scholarly journals Case Report of a Fatal Antifreeze Ingestion with a Record High Level and Impressive Renal Crystal Deposition

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Heidi L. Erickson
Keyword(s):  
Case Report ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Cerebral Edema ◽  
Diethylene Glycol ◽  
Significant Morbidity ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Autopsy Findings ◽  
High Level

Ethylene glycol, methanol, and diethylene glycol are readily available in many household and commercially available products. While these alcohols are relatively nontoxic themselves, their acidic metabolites are toxic and can result in significant morbidity and mortality. Herein we report a lethal case of massive ethylene glycol ingestion in a suicide with a record high level (1254 mg/dL) and images of the histologic examination of the kidneys revealing impressive calcium oxalate crystal deposition. Autopsy findings also showed evidence of mild cerebral edema.

scholarly journals The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Formation via Reducing the Liver Oxalate Biosynthesis and Renal Oxidative Stress-Mediated Cell Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Wei Zhu ◽  
Zhijian Zhao ◽  
Fu-Ju Chou ◽  
Li Zuo ◽  
Tongzu Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Estrogen Receptor ◽  
Nadph Oxidase ◽  
Calcium Oxalate ◽  
Cell Lines ◽  
Ros Production ◽  
Crystal Deposition ◽  
Caox Crystal

Females develop kidney stones less frequently than males do. However, it is unclear if this gender difference is related to altered estrogen/estrogen receptor (ER) signaling. Here, we found that ER beta (ERβ) signals could suppress hepatic oxalate biosynthesis via transcriptional upregulation of the glyoxylate aminotransferase (AGT1) expression. Results from multiple in vitro renal cell lines also found that ERβ could function via suppressing the oxalate-induced injury through increasing the reactive oxygen species (ROS) production that led to a decrease of the renal calcium oxalate (CaOx) crystal deposition. Mechanism study results showed that ERβ suppressed oxalate-induced oxidative stress via transcriptional suppression of the NADPH oxidase subunit 2 (NOX2) through direct binding to the estrogen response elements (EREs) on the NOX2 5′ promoter. We further applied two in vivo mouse models with glyoxylate-induced renal CaOx crystal deposition and one rat model with 5% hydroxyl-L-proline-induced renal CaOx crystal deposition. Our data demonstrated that mice lacking ERβ (ERβKO) as well as mice or rats treated with ERβ antagonist PHTPP had increased renal CaOx crystal deposition with increased urinary oxalate excretion and renal ROS production. Importantly, targeting ERβ-regulated NOX2 with the NADPH oxidase inhibitor, apocynin, can suppress the renal CaOx crystal deposition in the in vivo mouse model. Together, results from multiple in vitro cell lines and in vivo mouse/rat models all demonstrate that ERβ may protect against renal CaOx crystal deposition via inhibiting the hepatic oxalate biosynthesis and oxidative stress-induced renal injury.

scholarly journals Aluminum Citrate Prevents Renal Injury from Calcium Oxalate Crystal Deposition

2012 ◽  
Vol 23 (12) ◽  
pp. 2024-2033 ◽  
Author(s):  
Lauren M. Besenhofer ◽  
Marie C. Cain ◽  
Cody Dunning ◽  
Kenneth E. McMartin
Keyword(s):  
Calcium Oxalate ◽  
Renal Injury ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

Periplasmic cuticular calcium oxalate crystal deposition in Dracaena sanderiana

2001 ◽  
Vol 149 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Svoboda V. Pennisi ◽  
Dennis B. McConnell ◽  
Laurie B. Gower ◽  
Michael E. Kane ◽  
T. Lucansky
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Dracaena Sanderiana
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