scholarly journals JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression

Theranostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 4017-4029 ◽  
Author(s):  
Ji-Hye Kim ◽  
A-reum Hong ◽  
Yo-Han Kim ◽  
Hanju Yoo ◽  
Sang-Wook Kang ◽  
...  
Keyword(s):  
Mitf Expression ◽  
Transcription Coactivator

scholarly journals Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes

1995 ◽  
Vol 311 (1) ◽  
pp. 293-297 ◽  
Author(s):  
M Tomita ◽  
H Itoh ◽  
N Ishikawa ◽  
A Higa ◽  
H Ide ◽  
...  
Keyword(s):  
Goblet Cell ◽  
Goblet Cells ◽  
Recovery Phase ◽  
Nippostrongylus Brasiliensis ◽  
Trefoil Factor ◽  
Intestinal Trefoil Factor ◽  
Cell Hyperplasia ◽  
Reverse Transcription Pcr ◽  
Rapid Amplification ◽  
Mitf Expression

A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid amplification of cDNA ends methods. The gene was, similar to rat and human ITFs, mainly expressed in the small and large intestine. The mITF expression was up-regulated during the recovery phase after depletion of goblet cells in acetic acid-induced colitis. On the other hand, the expression in the jejunum was not altered, while goblet cell hyperplasia was induced by Nippostrongylus brasiliensis infection. These results suggest that the mITF expression did not simply correlate with the number of goblet cells. The mITF may play an important role in the maintenance and repair of mucosal function of the rectum. Additionally, the mITF in the jejunum may play a role in alteration of the physicochemical nature of goblet cell mucins, thereby affecting the establishment of intestinal helminths.

Cell cycle inhibitor p21/ WAF1/ CIP1 as a cofactor of MITF expression in melanoma cells

2010 ◽  
Vol 23 (2) ◽  
pp. 238-251 ◽  
Author(s):  
Blanka Šestáková ◽  
Lubica Ondrušová ◽  
Jiri Vachtenheim
Keyword(s):  
Cell Cycle ◽  
Melanoma Cells ◽  
Cell Cycle Inhibitor ◽  
P21 Waf1 ◽  
Mitf Expression

scholarly journals Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

Hepatology ◽  
2011 ◽  
Vol 53 (4) ◽  
pp. 1164-1174 ◽  
Author(s):  
Liang Bai ◽  
Yuzhi Jia ◽  
Navin Viswakarma ◽  
Jiansheng Huang ◽  
Aurore Vluggens ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Transcription Coactivator

scholarly journals Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling

2019 ◽  
Vol 20 (3) ◽  
pp. 576 ◽  
Author(s):  
Tamar Golan ◽  
Carmit Levy
Keyword(s):  
Transcription Factor ◽  
Notch Signaling ◽  
Transcriptional Activity ◽  
Treatment Resistance ◽  
Gene Encoding ◽  
Reciprocal Interactions ◽  
Melanoma Progression ◽  
Regulatory Loop ◽  
Signaling Activation ◽  
Mitf Expression

Melanoma, a melanocyte-origin neoplasm, is a highly metastatic and treatment-resistance cancer. While it is well established that notch signaling activation promotes melanoma progression, little is known about the reciprocal interactions between Notch signaling and melanoma-specific pathways. Here we reveal a negative regulatory loop between Notch signaling and microphthalmia-associated transcription factor (MITF), the central regulator of melanoma progression and the driver of melanoma plasticity. We further demonstrate that Notch signaling activation, in addition to the known competition-based repression mechanism of MITF transcriptional activity, inhibits the transcription of MITF, leading to a decrease in MITF expression. We also found that MITF binds to the promoter of the gene encoding the master regulator of Notch signaling, recombination signal binding protein J kappa (RBPJK), leading to its upregulation. Our findings suggest that, once activated, Notch signaling represses MITF signaling to maintain the melanoma invasiveness and metastatic phenotype.

NEDD4L limits cAMP signaling through ubiquitination of CREB‐regulated transcription coactivator 3

2018 ◽  
Vol 32 (7) ◽  
pp. 4053-4062 ◽  
Author(s):  
Yo‐Han Kim ◽  
Hanju Yoo ◽  
A‐Reum Hong ◽  
Minseo Kwon ◽  
Sang‐Wook Kang ◽  
...  
Keyword(s):  
Camp Signaling ◽  
Transcription Coactivator
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