scholarly journals Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

Theranostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 3413-3429 ◽  
Author(s):  
Bowen Qi ◽  
Ayrianne J. Crawford ◽  
Nicholas E. Wojtynek ◽  
Geoffrey A. Talmon ◽  
Michael A. Hollingsworth ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Hyaluronic Acid ◽  
Near Infrared ◽  
Intraoperative Imaging

scholarly journals Abstract 4102: Surgical imaging of pancreatic cancer using near infrared fluorescent hyaluronic acid nanomaterials

2018 ◽  
Author(s):  
Bowen Qi ◽  
Ayrianne Crawford ◽  
Samuel Cohen ◽  
Michael Hollingsworth ◽  
Aaron M. Mohs
Keyword(s):  
Pancreatic Cancer ◽  
Hyaluronic Acid ◽  
Near Infrared

scholarly journals Development of a MUC16-Targeted Near-Infrared Fluorescent Antibody Conjugate for Intraoperative Imaging of Pancreatic Cancer

2020 ◽  
Vol 19 (8) ◽  
pp. 1670-1681 ◽  
Author(s):  
Madeline T. Olson ◽  
Nicholas E. Wojtynek ◽  
Geoffrey A. Talmon ◽  
Thomas C. Caffrey ◽  
Prakash Radhakrishnan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Near Infrared ◽  
Intraoperative Imaging ◽  
Fluorescent Antibody ◽  
Antibody Conjugate

scholarly journals Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Henricus J. M. Handgraaf ◽  
Martin C. Boonstra ◽  
Arian R. Van Erkel ◽  
Bert A. Bonsing ◽  
Hein Putter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Surgery ◽  
Near Infrared ◽  
Frozen Section ◽  
Intraoperative Imaging ◽  
Meta Analysis ◽  
Survival Rates ◽  
Radical Resection ◽  
Resection Margins ◽  
Curative Intent

Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. Currently, ultrasonography is used during surgery for resectability assessment and frozen-section analysis is used for assessment of resection margins in order to decrease the number of irradical resections. The introduction of minimal invasive techniques in pancreatic surgery has deprived surgeons from direct tactile information. To improve intraoperative assessment of pancreatic tumor extension, enhanced or novel intraoperative imaging technologies accurately visualizing and delineating cancer cells are necessary. Emerging modalities are intraoperative near-infrared fluorescence imaging and freehand nuclear imaging using tumor-specific targeted contrast agents. In this review, we performed a meta-analysis of the literature on laparoscopic ultrasonography and we summarized and discussed current and future intraoperative imaging modalities and their potential for improved tumor demarcation during pancreatic surgery.

scholarly journals Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

ACS Omega ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 154-163 ◽  
Author(s):  
Lei Wang ◽  
Connor W. Barth ◽  
Martha Sibrian-Vazquez ◽  
Jorge O. Escobedo ◽  
Mark Lowry ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Near Infrared ◽  
Cancer Imaging
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